MCA_01027_1

Protein

Length

179 amino acids

RNA-seq: read pairs 3145, FPKM 215.9, percentile rank 89.0% (100% = highest expression)

Protein function

KEGG:	K00794	ribH	6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
EGGNOG:	0PPKX	FG01164.1	6,7-dimethyl-8-ribityllumazine synthase
SGD closest match:	S000005503	RIB4	6,7-dimethyl-8-ribityllumazine synthase
CGD closest match:	CAL0000184983	RIB4	6,7-dimethyl-8-ribityllumazine synthase

Protein alignments

	%id	Aln length	E-value
MIA_02076_1	72.94%	170	6e-88	MIA_02076_1
A0A0J9XGY4_GEOCN	66.08%	171	3e-79	6,7-dimethyl-8-ribityllumazine synthase OS=Geotrichum candidum GN=BN980_GECA16s01297g PE=3 SV=1
A0A1E3PIB3_9ASCO	65.29%	170	1e-75	6,7-dimethyl-8-ribityllumazine synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46901 PE=3 SV=1
A0A060THW1_BLAAD	62.87%	167	4e-73	6,7-dimethyl-8-ribityllumazine synthase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41206g PE=3 SV=1
A0A1D8PDK6_CANAL	61.68%	167	2e-70	6,7-dimethyl-8-ribityllumazine synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RIB4 PE=3 SV=1
RIB4_YEAST	61.68%	167	3e-71	6,7-dimethyl-8-ribityllumazine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIB4 PE=1 SV=2
UniRef50_P50861	61.68%	167	8e-68	6,7-dimethyl-8-ribityllumazine synthase n=80 Tax=Fungi TaxID=4751 RepID=RIB4_YEAST
Q6CH62_YARLI	57.74%	168	3e-62	6,7-dimethyl-8-ribityllumazine synthase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A12045g PE=3 SV=1
A0A167E1H6_9ASCO	70.27%	74	5e-31	Lumazine synthase RIB4 OS=Sugiyamaella lignohabitans GN=RIB4 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0128

Protein family membership

Lumazine/riboflavin synthase (IPR002180)
- Lumazine synthase (IPR034964)

Domains and repeats

None predicted.

Detailed signature matches

IPR002180

Lumazine/riboflavin synthase
1. G3DSA:3.40.50...
  
  78 - 179
  
  GENE3D
  G3DSA:3.40.50.960 (G3DSA:3.40.50.960)
  
  5 - 77
  
  GENE3D
  G3DSA:3.40.50.960 (G3DSA:3.40.50.960)
2. PF00885 (DMRL_synthase)
  
  20 - 169
  
  Pfam
  PF00885 (DMRL_synthase)
3. SSF52121 (Lumazine ...)
  
  12 - 176
  
  SUPERFAMILY
  SSF52121 (Lumazine synthase)
IPR034964

Lumazine synthase
1. MF_00178 (Lumazine_...)
  
  15 - 175
  
  HAMAP
  MF_00178 (Lumazine_synth)
2. cd09209 (Lumazine_s...)
  
  22 - 168
  
  CDD
  cd09209 (Lumazine_synthase-I)
3. TIGR00114
  
  20 - 168
  
  TIGRFAMs
  TIGR00114 (TIGR00114)

Residue annotation

homopentamer inter...

23G

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

29W

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

58T

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

59T

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

60V

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

61P

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

64Y

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

65E

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

67P

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

68F

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

69G

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

71E

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

72T

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

73F

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

75L

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

86F

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

97K

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

99Q

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

100T

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

102H

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

104E

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

105Y

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

107S

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

108D

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

109A

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

111S

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

112H

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

113G

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

115M

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

116N

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

117V

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

118Q

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

119F

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

122D

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

123I

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

127F

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

129L

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

131T

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

133L

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

137Q

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

141R

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

157H

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

160D

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

164A

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

167E

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)

168M

homopentamer interface
23G, 29W, 58T, 59T, 60V, 61P, 64Y, 65E, 67P, 68F, 69G, 71E, 72T, 73F, 75L, 86F, 97K, 99Q, 100T, 102H, 104E, 105Y, 107S, 108D, 109A, 111S, 112H, 113G, 115M, 116N, 117V, 118Q, 119F, 122D, 123I, 127F, 129L, 131T, 133L, 137Q, 141R, 157H, 160D, 164A, 167E, 168M
CDD
cd09209 (Lumazine_synthase-I)
active site cd09209

29W

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

30N

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

62G

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

63S

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

64Y

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

65E

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

93G

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

94V

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

95L

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

96I

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

97K

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

98G

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

100T

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

102H

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

103F

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

126I

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

127F

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

128G

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

129L

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

130L

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

141R

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

157H

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

160D

active site
29W, 30N, 62G, 63S, 64Y, 65E, 93G, 94V, 95L, 96I, 97K, 98G, 100T, 102H, 103F, 126I, 127F, 128G, 129L, 130L, 141R, 157H, 160D
CDD
cd09209 (Lumazine_synthase-I)

Protein sequence

>MCA_01027_1
MAGQIKGLGSVDKTYDGSNLRVGIIHARWNQKVIASLVDGAVNELKRLGVKESNIVVTTVPGSYELPFGTETFFLSDKAE
NKDAPFDAIISIGVLIKGQTMHFEYISDAVSHGLMNVQFKLDIPVIFGLLTCLTEEQALERAGLIETEKGASHSHNHGVD
WGAAAVEMGYKKKNLSGHK

GO term prediction

Biological Process

GO:0009231 riboflavin biosynthetic process

Molecular Function

GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity

Cellular Component

GO:0009349 riboflavin synthase complex

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Entry type

Status

Per-residue features