MCA_00992_1

Protein

Length

1,459 amino acids

Gene name: KIN1

Description: Serine/threonine protein kinase Kin1, in S. cerevisiae involved in regulation of exocytosis.

Browser: contigA:3152443-3156886-

RNA-seq: read pairs 4160, FPKM 35.2, percentile rank 57.3% (100% = highest expression)

Protein function

Annotation:		KIN1	Serine/threonine protein kinase Kin1, in S. cerevisiae involved in regulation of exocytosis.
KEGG:	K19852	KIN1_2	serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
EGGNOG:	0PFZJ	KIN1	serine threonine protein kinase
SGD closest match:	S000002529	KIN1	Serine/threonine protein kinase KIN1
CGD closest match:	CAL0000177153	KIN2	Non-specific serine/threonine protein kinase

Protein alignments

	%id	Aln length	E-value
MIA_06187_1	71.18%	451	0.0	MIA_06187_1
A0A0J9XIB4_GEOCN	67.73%	437	0.0	Non-specific serine/threonine protein kinase OS=Geotrichum candidum GN=BN980_GECA16s01583g PE=4 SV=1
UniRef50_A0A0J9XIB4	67.73%	437	0.0	Non-specific serine/threonine protein kinase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIB4_GEOCN
A0A161HLG9_9ASCO	62.50%	464	0.0	Non-specific serine/threonine protein kinase OS=Sugiyamaella lignohabitans GN=KIN2 PE=4 SV=1
A0A060TDK3_BLAAD	61.43%	446	0.0	Non-specific serine/threonine protein kinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D44594g PE=4 SV=1
W0TYN3_YARLI	60.97%	433	4e-176	Non-specific serine/threonine protein kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D22770g PE=4 SV=1
A0A1E3PRX9_9ASCO	57.96%	452	2e-162	Non-specific serine/threonine protein kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81218 PE=4 SV=1
A0A1D8PRN8_CANAL	55.92%	397	7e-145	Non-specific serine/threonine protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KIN2 PE=4 SV=1
A0A1E4THD0_9ASCO	52.68%	429	2e-147	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20657 PE=3 SV=1
KIN1_YEAST	48.97%	439	2e-127	Serine/threonine protein kinase KIN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIN1 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0067

Protein family membership

None predicted.

Domains and repeats

Domain
394 - 668
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)
824 - 864
Protein kinase-like domain (IPR011009)
1,214 - 1,275
KA1 domain/Ssp2, C-terminal (IPR028375)
1,410 - 1,459
KA1 domain/Ssp2, C-terminal (IPR028375)
Kinase associated domain 1 (KA1) (IPR001772)

1 200 400 600 800 1000 1200 1459

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  394 - 668
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  824 - 864
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  397 - 667
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. SM00220 (serkin_6)
  
  397 - 667
  
  SMART
  SM00220 (serkin_6)
3. PF00069 (Pkinase)
  
  399 - 667
  
  Pfam
  PF00069 (Pkinase)
IPR028375

KA1 domain/Ssp2, C-terminal
1. SSF103243 (KA1-like)
  
  1,214 - 1,275
  
  SUPERFAMILY
  SSF103243 (KA1-like)
  
  1,413 - 1,459
  
  SUPERFAMILY
  SSF103243 (KA1-like)
IPR001772

Kinase associated domain 1 (KA1)
1. PF02149 (KA1)
  
  1,416 - 1,459
  
  Pfam
  PF02149 (KA1)
2. PS50032 (KA1)
  
  1,410 - 1,459
  
  PROSITE profiles
  PS50032 (KA1)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  403 - 426
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  534 - 546
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

1,454 - 1,459

COILS
Coil (Coil)
G3DSA:1.10.11...

237 - 389

GENE3D
G3DSA:1.10.110.10 (G3DSA:1.10.110.10)
G3DSA:1.10.51...

511 - 894

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

390 - 510

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
G3DSA:3.30.31...

1,210 - 1,459

GENE3D
G3DSA:3.30.310.80 (G3DSA:3.30.310.80)
cd12121 (MARK_C_like)

1,411 - 1,457

CDD
cd12121 (MARK_C_like)
cd14077 (STKc_Kin1_2)

395 - 667

CDD
cd14077 (STKc_Kin1_2)
mobidb-lite (disord...)

773 - 799

MobiDB Lite
mobidb-lite (disorder_prediction)

1,280 - 1,309

MobiDB Lite
mobidb-lite (disorder_prediction)

1,055 - 1,129

MobiDB Lite
mobidb-lite (disorder_prediction)

1,165 - 1,217

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 57

MobiDB Lite
mobidb-lite (disorder_prediction)

434 - 459

MobiDB Lite
mobidb-lite (disorder_prediction)

823 - 893

MobiDB Lite
mobidb-lite (disorder_prediction)

82 - 277

MobiDB Lite
mobidb-lite (disorder_prediction)

301 - 393

MobiDB Lite
mobidb-lite (disorder_prediction)

931 - 1,043

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

403V

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

404G

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

405A

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

406G

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

411V

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

424A

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

426K

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

476C

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

492F

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

493E

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

494Y

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

495V

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

499Q

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

542E

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

543N

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

545L

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

555I

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)

556D

ATP binding site
403V, 404G, 405A, 406G, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 542E, 543N, 545L, 555I, 556D
CDD
cd14077 (STKc_Kin1_2)
active site cd14077

403V

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

404G

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

405A

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

406G

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

407S

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

411V

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

424A

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

426K

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

476C

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

492F

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

493E

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

494Y

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

495V

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

499Q

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

501L

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

502D

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

504I

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

537R

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

538D

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

540K

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

542E

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

543N

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

545L

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

555I

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

556D

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

559L

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

573C

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

574G

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

575S

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

576L

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

577Y

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

579A

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

609G

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

610K

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

611V

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

612P

active site
403V, 404G, 405A, 406G, 407S, 411V, 424A, 426K, 476C, 492F, 493E, 494Y, 495V, 499Q, 501L, 502D, 504I, 537R, 538D, 540K, 542E, 543N, 545L, 555I, 556D, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)
polypeptide substr...

499Q

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

501L

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

502D

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

504I

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

538D

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

540K

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

542E

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

559L

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

573C

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

574G

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

575S

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

576L

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

577Y

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

579A

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

609G

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

610K

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

611V

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)

612P

polypeptide substrate binding site
499Q, 501L, 502D, 504I, 538D, 540K, 542E, 559L, 573C, 574G, 575S, 576L, 577Y, 579A, 609G, 610K, 611V, 612P
CDD
cd14077 (STKc_Kin1_2)
activation loop (A...

555I

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

556D

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

557F

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

558G

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

559L

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

560S

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

561N

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

562L

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

563Y

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

564R

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

565R

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

566D

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

567G

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

568L

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

569L

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

570K

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

571T

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

572F

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

573C

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

574G

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

575S

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

576L

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)

577Y

activation loop (A-loop)
555I, 556D, 557F, 558G, 559L, 560S, 561N, 562L, 563Y, 564R, 565R, 566D, 567G, 568L, 569L, 570K, 571T, 572F, 573C, 574G, 575S, 576L, 577Y
CDD
cd14077 (STKc_Kin1_2)
putative phospholi...

1,435Q

putative phospholipid binding site
1,435Q, 1,437K, 1,438K
CDD
cd12121 (MARK_C_like)

1,437K

putative phospholipid binding site
1,435Q, 1,437K, 1,438K
CDD
cd12121 (MARK_C_like)

1,438K

putative phospholipid binding site
1,435Q, 1,437K, 1,438K
CDD
cd12121 (MARK_C_like)

Protein sequence

>MCA_00992_1
MPTQPGSHQSPFDDSNSIDIHTSQYSPPKRVSLSHNRSISSRTNPSSRPPSDYGDQWVPQVSTHVASNSNYNNNILPQAI
LPETNLTRNHSKGRYTRSNNIDYSQTQDHHNSNSAYQSNKRHSNNVPGASPDNNNNNTSASYNNNSNNANNNYYHSTNPT
SPQIPAFSSSSSTSSSSKYHHHGHSTSTSSPSYYTPPTPSHQPSQFNNNINNPPHHQSTSVAYTSALSPTGPSSTKKNSL
SVPSAVLPSAQVQRSYSTHKHSSSRSRNTHNNSTETPTYVNPAVAAAAIAQQAHIQQSAYSSNNSYSANSKMSSFSPPEL
HYNEPEVSSQPQTRSAVLAQPVNPPQSTSAQPQSSQQQQQQQQQQQQQQSVQRSGSKSASGSSGAHKIHKRRSIGEWDLI
KTVGAGSMGQVKLARNRETGACCAIKVVPRASVEHKKKLQQGKETNSSNKESDESKDNRTVREAAIGRLLHHRYICELYE
MHIMTSHYYMLFEYVSGGQMLDYIIAHGSLKEKQARKFSRAIASALDYCHHNNIVHRDLKIENILISQSGDIKIIDFGLS
NLYRRDGLLKTFCGSLYFAAPELLSAEPYCGPEIDVWSFGVVLYVLVCGKVPFDDQSMPALHAKIKRGFVEYPSWLSSDC
KDLIARMLTVDHTQRATLQEVRYHPWMMKGYDKPPDSYLPERKPLSLPLDEAVIADMSGFDFGDPDAIRKELQSIIESPA
YVNACREWYKIHNGDSEEQHSLTPESTTGSYNQNRRSKHFSIDFYKRRSSISEDGNSLSTTISNNGSASTNNSSKIVDPT
NAYHPLISIYYLVKERQERLRNSGMDKPKVTLPTNVPPQQDQTSKQQQQYAPVQQQTPVQISSQNTASRHQPSRSVSVKS
TSRGHSYTKSVPVAAFNQDTSTVSDDRRFLAPTIPAPEAVHTSTNYRQGAQIPVPMQPTSNAPEIIPSRSRNRSKTQNAI
DNPESLHTLGSGNTGSSGSSAGGDQYESNKSATGLATSLLRRFSSKRKNNREVSSPTTMTTMAYQQQQKSRHHHSQSASP
AVGDINLDEPLYQATNSNYRQGPNSPLSAPPQTSNANGSLSRSTSTKQSAKQNSGENSNPSNSNATVTKSTSAPRKFHPS
ARAKSLGHVRHEMLTRQHLKDENQSGTATPGSADIADEFFDEYFGEPESKTSNTNSIRRNSSKNAINPTKYLNTSGGTDK
LQSQSKSAQTSPITESMPSIEYPKQVFLKGFFSVQSTSTKPLAYIRSDIIRVLTQLGVEFDEIRGGFNCIHKPSIQYHQY
TAPNSPVTNTSSGSPPQSPPSENLQQPQRGHWRKLSFGSGLFSNRRSKYQNESSGNFFDFSSDISTDSVGASPPGGASAA
ALANLGMSSSSGGAGQTSASGSTAGMNGGYAGGSDMLSSNIPGGAPTAHMSGLRTPLQFEIWIVRVPLLSLHGVQFKKLR
GNSWEYKNLATKILSELRL

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component