Protein
MCA_00965_1
Length
1,296 amino acids
Gene name: MYO5
Description: Myosin-5
Browser: contigA:3056286-3060260-
RNA-seq: read pairs 6889, FPKM 65.6, percentile rank 71.1% (100% = highest expression)
Protein function
Annotation: | MYO5 | Myosin-5 | |
---|---|---|---|
KEGG: | K10356 | MYO1 | myosin I |
EGGNOG: | 0PGUQ | MYO1 | Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2 3 complex |
SGD closest match: | S000004715 | MYO5 | Myosin-5 |
CGD closest match: | CAL0000199209 | MYO5 | Myosin-5 |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_01901_1 | 83.09% | 970 | 0.0 | MIA_01901_1 |
A0A0J9XDY1_GEOCN | 79.32% | 967 | 0.0 | Similar to Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins OS=Geotrichum candidum GN=BN980_GECA11s01836g PE=3 SV=1 |
A0A060TBS7_BLAAD | 73.63% | 967 | 0.0 | ARAD1D37268p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37268g PE=3 SV=1 |
A0A1E3PEV4_9ASCO | 70.16% | 972 | 0.0 | Myosin-1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84010 PE=3 SV=1 |
MYO1_YARLI | 69.56% | 969 | 0.0 | Myosin-1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MYO1 PE=3 SV=1 |
MYO5_YEAST | 67.29% | 966 | 0.0 | Myosin-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MYO5 PE=1 SV=1 |
UniRef50_P36006 | 67.36% | 968 | 0.0 | Myosin-3 n=39 Tax=Dikarya TaxID=451864 RepID=MYO3_YEAST |
A0A1E4TL20_9ASCO | 67.81% | 963 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56105 PE=3 SV=1 |
MYO5_CANAL | 66.63% | 986 | 0.0 | Myosin-5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MYO5 PE=1 SV=2 |
A0A167EFC6_9ASCO | 73.42% | 854 | 0.0 | Myosin 5 OS=Sugiyamaella lignohabitans GN=MYO5 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4876
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1296
Detailed signature matches
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SSF52540 (P-loop co...)
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no IPR
Unintegrated signatures
-
-
-
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cd01378 (MYSc_Myo1)
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mobidb-lite (disord...)
Residue annotation
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purine-binding loo...
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ATP binding site c...
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P-loop cd01378
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switch I region cd...
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switch II region c...
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relay loop cd01378
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SH1 helix cd01378
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converter subdomai...
Protein sequence
>MCA_00965_1 MAKTQRAGRRAEKKQPPPKRNDGIQKATFDATKKKEVGVSDLTLLSKVSDESINDNLHKRFENGIIYTYIGHVLISVNPF RDLGIYTDAVLQSYKGKNRLEVPPHVFAVAEAMYYNMKSYSENQCVIISGESGAGKTEAAKRIMQYIASVSGESSSNIQK IKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLQIQFNRQGEPIGANITNYLLEKARVVGQIINERNFHIFYQLTKGATA QQRELYGIQGPETYTYTSGSKCVSVDGIDDVQDFAETLRSMEIIGLHQSEQDQIFRLLAAILWIGNISFVENNEGNAAIK DSSVTNFVAYLLEVNAQDIEKALTERIVETSRGIGRRGSVYEVPLNPVQARAVRDALAKAIYNNLFDWIVERLNQSLEAK EGKDKTIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIQLTLKTEQEEYVREQIKWTPIDYFNNKIVCDLIEEKRPPG IFAALNDSIATAHADSNAADQNFAQRLSLLSSNPHFDHRQSKFLIKHYAGDVLYDINGMTDKNKDQLLKDLLLLISKSGN QFLQIIFPNQVDTDSRRRPPTASDKIKASANDLMNTLSQAQPSYIRTIKPNQTKSPQDYDTKMVLHQVKYLGLHENVRIR RAGFAYRQTFDKFTERFYLLSGKTSYAGDYIWTGDSRSATTEILKDAGIPASEFQMGTTKVFIKTPETLFSLEHMRDMYW HNMAARIQRAWRKFQQRKIDAAVKIQRAWRLQRDGDIYQILRDKGHTIYNNRKQRRRYSLNGYRRFMGDYLGCNDPKSPG GFIARSAGINEPVIFSMDGEILHAKFGRSSQRLPRKFLLTHSRLFIITSQLINNQLTVVVEKTIQVPSIKYLGLSSLSDD WLAISVQAPNEPDSFINCMFKTELVTQLKEIRPGLEVKIGPTVQYYKKPGKLTTVKFELDSTAGANDHYKSGTVRIGPGC PANSRSDPTPKRTRKPTTGYTPKPKPMPLRQQAAKRVPPPPPPVANNFARPQNPIQPPQPQQQQQQQQQRQHSIPQPPQQ RQQQAPVRMPEPFGGSRTNNGMSAAISAANAAYHPQPPAPINRPVNRKPMVSPGNSRPSSGVYGNSAAAATPAATPAATH AQPPPPPPPEPVAPPQPPAQDPLYKVLYDFTGSESNQLSITKDEYLFMLKQGNEGWCLVRRQNSSEEGWAPFAYLQEVKN EPPSRPPVGRKKPAPAPPAKNKALAGYASNGNSTPSTNGYNTPGAASSAQTAAPLATGLAEALKQKNQQNNSLAGGLAEA LKARSGRHDSDDDDDW
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex