Protein

MCA_00965_1

Length
1,296 amino acids


Gene name: MYO5

Description: Myosin-5

Browser: contigA:3056286-3060260-

RNA-seq: read pairs 6889, FPKM 65.6, percentile rank 71.1% (100% = highest expression)

Protein function

Annotation:MYO5Myosin-5
KEGG:K10356MYO1 myosin I
EGGNOG:0PGUQMYO1Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2 3 complex
SGD closest match:S000004715MYO5Myosin-5
CGD closest match:CAL0000199209MYO5Myosin-5

Protein alignments

%idAln lengthE-value
MIA_01901_183.09%9700.0MIA_01901_1
A0A0J9XDY1_GEOCN79.32%9670.0Similar to Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins OS=Geotrichum candidum GN=BN980_GECA11s01836g PE=3 SV=1
A0A060TBS7_BLAAD73.63%9670.0ARAD1D37268p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37268g PE=3 SV=1
A0A1E3PEV4_9ASCO70.16%9720.0Myosin-1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84010 PE=3 SV=1
MYO1_YARLI69.56%9690.0Myosin-1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MYO1 PE=3 SV=1
MYO5_YEAST67.29%9660.0Myosin-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MYO5 PE=1 SV=1
UniRef50_P3600667.36%9680.0Myosin-3 n=39 Tax=Dikarya TaxID=451864 RepID=MYO3_YEAST
A0A1E4TL20_9ASCO67.81%9630.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56105 PE=3 SV=1
MYO5_CANAL66.63%9860.0Myosin-5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MYO5 PE=1 SV=2
A0A167EFC6_9ASCO73.42%8540.0Myosin 5 OS=Sugiyamaella lignohabitans GN=MYO5 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4876

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1296

Detailed signature matches

    1. SSF52540 (P-loop co...)
    1. SM00242 (MYSc_2a)
    2. PS51456 (MYOSIN_MOTOR)
    3. PR00193 (MYOSINHEAVY)
    4. PF00063 (Myosin_head)
    1. PF06017 (Myosin_TH1)
    2. PS51757 (TH1)
    1. PF00018 (SH3_1)
    2. SM00326 (SH3_2)
    3. SSF50044 (SH3-domain)
    4. PS50002 (SH3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd01378 (MYSc_Myo1)
  2. mobidb-lite (disord...)

Residue annotation

  1. purine-binding loo...
  2. ATP binding site c...
  3. P-loop cd01378
  4. switch I region cd...
  5. switch II region c...
  6. relay loop cd01378
  7. SH1 helix cd01378
  8. converter subdomai...

Protein sequence

>MCA_00965_1
MAKTQRAGRRAEKKQPPPKRNDGIQKATFDATKKKEVGVSDLTLLSKVSDESINDNLHKRFENGIIYTYIGHVLISVNPF
RDLGIYTDAVLQSYKGKNRLEVPPHVFAVAEAMYYNMKSYSENQCVIISGESGAGKTEAAKRIMQYIASVSGESSSNIQK
IKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLQIQFNRQGEPIGANITNYLLEKARVVGQIINERNFHIFYQLTKGATA
QQRELYGIQGPETYTYTSGSKCVSVDGIDDVQDFAETLRSMEIIGLHQSEQDQIFRLLAAILWIGNISFVENNEGNAAIK
DSSVTNFVAYLLEVNAQDIEKALTERIVETSRGIGRRGSVYEVPLNPVQARAVRDALAKAIYNNLFDWIVERLNQSLEAK
EGKDKTIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIQLTLKTEQEEYVREQIKWTPIDYFNNKIVCDLIEEKRPPG
IFAALNDSIATAHADSNAADQNFAQRLSLLSSNPHFDHRQSKFLIKHYAGDVLYDINGMTDKNKDQLLKDLLLLISKSGN
QFLQIIFPNQVDTDSRRRPPTASDKIKASANDLMNTLSQAQPSYIRTIKPNQTKSPQDYDTKMVLHQVKYLGLHENVRIR
RAGFAYRQTFDKFTERFYLLSGKTSYAGDYIWTGDSRSATTEILKDAGIPASEFQMGTTKVFIKTPETLFSLEHMRDMYW
HNMAARIQRAWRKFQQRKIDAAVKIQRAWRLQRDGDIYQILRDKGHTIYNNRKQRRRYSLNGYRRFMGDYLGCNDPKSPG
GFIARSAGINEPVIFSMDGEILHAKFGRSSQRLPRKFLLTHSRLFIITSQLINNQLTVVVEKTIQVPSIKYLGLSSLSDD
WLAISVQAPNEPDSFINCMFKTELVTQLKEIRPGLEVKIGPTVQYYKKPGKLTTVKFELDSTAGANDHYKSGTVRIGPGC
PANSRSDPTPKRTRKPTTGYTPKPKPMPLRQQAAKRVPPPPPPVANNFARPQNPIQPPQPQQQQQQQQQRQHSIPQPPQQ
RQQQAPVRMPEPFGGSRTNNGMSAAISAANAAYHPQPPAPINRPVNRKPMVSPGNSRPSSGVYGNSAAAATPAATPAATH
AQPPPPPPPEPVAPPQPPAQDPLYKVLYDFTGSESNQLSITKDEYLFMLKQGNEGWCLVRRQNSSEEGWAPFAYLQEVKN
EPPSRPPVGRKKPAPAPPAKNKALAGYASNGNSTPSTNGYNTPGAASSAQTAAPLATGLAEALKQKNQQNNSLAGGLAEA
LKARSGRHDSDDDDDW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003774 motor activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0016459 myosin complex