MCA_00962_1

Protein

Length

1,520 amino acids

Gene name: YPK9

Description: Vacuolar cation-transporting ATPase YPK9

Browser: contigA:3047123-3051686-

RNA-seq: read pairs 2840, FPKM 23.1, percentile rank 45.3% (100% = highest expression)

Protein function

Annotation:		YPK9	Vacuolar cation-transporting ATPase YPK9
KEGG:	K14951	ATP13A3_4_5	cation-transporting P-type ATPase 13A3/4/5 [EC:3.6.3.-]
EGGNOG:	0PH07	FG07466.1	P-type ATPase
SGD closest match:	S000005817	YPK9	Vacuolar cation-transporting ATPase YPK9
CGD closest match:	CAL0000199066	orf19.1573	Cation-transporting ATPase

Protein alignments

	%id	Aln length
MIA_01903_1	68.11%	1433	MIA_01903_1
A0A0J9XDC9_GEOCN	63.22%	1365	Cation-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA11s02639g PE=3 SV=1
UniRef50_A0A0J9XDC9	63.22%	1365	Cation-transporting ATPase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDC9_GEOCN
A0A167ELY3_9ASCO	53.33%	1395	Cation-transporting ATPase OS=Sugiyamaella lignohabitans GN=YPK9 PE=3 SV=1
A0A060TCR2_BLAAD	52.98%	1374	Cation-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D44946g PE=3 SV=1
A0A1E3PRX7_9ASCO	50.44%	1477	Cation-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_72594 PE=3 SV=1
Q6C829_YARLI	56.02%	1230	Cation-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23265g PE=3 SV=1
A0A1E4TJW5_9ASCO	49.33%	1263	Cation-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30324 PE=3 SV=1
YPK9_YEAST	49.01%	1263	Vacuolar cation-transporting ATPase YPK9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPK9 PE=1 SV=1
A0A1D8PGL4_CANAL	48.07%	1215	Cation-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1573 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1235

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily V (IPR006544)

Domains and repeats

Domain
491 - 584
P-type ATPase, transmembrane domain (IPR023298)
718 - 815
P-type ATPase, transmembrane domain (IPR023298)
1,265 - 1,474
P-type ATPase, transmembrane domain (IPR023298)
Domain
585 - 720
P-type ATPase, A domain (IPR008250)
758 - 1,268
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)

1 200 400 600 800 1000 1200 1400 1520

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  735 - 843
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  1,189 - 1,296
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006544

P-type ATPase, subfamily V
1. PF12409 (P5-ATPase)
  
  323 - 467
  
  Pfam
  PF12409 (P5-ATPase)
2. TIGR01657
  
  326 - 1,464
  
  TIGRFAMs
  TIGR01657 (TIGR01657)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  718 - 815
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  491 - 584
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,265 - 1,474
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  585 - 720
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  1,191 - 1,268
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  1,011 - 1,120
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  817 - 832
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  1,057 - 1,245
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  947 - 1,069
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
  
  827 - 917
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  758 - 1,056
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  823 - 829
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

567 - 734

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,324 - 1,342

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

794 - 1,278

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,482 - 1,520

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,409 - 1,419

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

361 - 518

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

231 - 265

COILS
Coil (Coil)
G3DSA:1.20.11...

1,246 - 1,483

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

487 - 722

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

1,366 - 1,388

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,441 - 1,459

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 339

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

756 - 766

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

541 - 545

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,298 - 1,302

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

585 - 801

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

980 - 1,103

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

631 - 645

PRINTS
PR00119 (CATATPASE)

1,159 - 1,169

PRINTS
PR00119 (CATATPASE)

821 - 835

PRINTS
PR00119 (CATATPASE)

1,218 - 1,237

PRINTS
PR00119 (CATATPASE)
PS01229 (COF_2)

1,218 - 1,240

PROSITE patterns
PS01229 (COF_2)
TMhelix

1,343 - 1,362

TMHMM
TMhelix (TMhelix)

1,459 - 1,481

TMHMM
TMhelix (TMhelix)

1,389 - 1,408

TMHMM
TMhelix (TMhelix)

773 - 795

TMHMM
TMhelix (TMhelix)

546 - 566

TMHMM
TMhelix (TMhelix)

736 - 758

TMHMM
TMhelix (TMhelix)

1,308 - 1,330

TMHMM
TMhelix (TMhelix)

1,276 - 1,298

TMHMM
TMhelix (TMhelix)

339 - 361

TMHMM
TMhelix (TMhelix)

1,420 - 1,439

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

767 - 793

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,303 - 1,323

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

340 - 360

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,389 - 1,408

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,460 - 1,481

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,279 - 1,297

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,420 - 1,440

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

735 - 755

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,343 - 1,365

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

519 - 540

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

546 - 566

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd07542 (P-type_ATP...)

497 - 1,388

CDD
cd07542 (P-type_ATPase_cation)
mobidb-lite (disord...)

251 - 271

MobiDB Lite
mobidb-lite (disorder_prediction)

410 - 446

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 125

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

823D

phosphorylation site
823D
CDD
cd07542 (P-type_ATPase_cation)
P-type ATPase sign...

823D

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

824K

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

825T

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

826G

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

827T

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

828L

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)

829T

P-type ATPase signature motif
823D, 824K, 825T, 826G, 827T, 828L, 829T
CDD
cd07542 (P-type_ATPase_cation)
putative ATP bindi...

823D

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

824K

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

825T

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

961F

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

992K

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

993G

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

994A

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,026I

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,088T

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,089G

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,090D

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,195R

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,198P

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,201K

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,220D

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)

1,223N

putative ATP binding site
823D, 824K, 825T, 961F, 992K, 993G, 994A, 1,026I, 1,088T, 1,089G, 1,090D, 1,195R, 1,198P, 1,201K, 1,220D, 1,223N
CDD
cd07542 (P-type_ATPase_cation)
putative cation bi...

1,277K

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,281L

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,282Y

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,284A

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,285I

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,301G

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,304Q

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

1,305F

putative cation binding site
1,277K, 1,281L, 1,282Y, 1,284A, 1,285I, 1,301G, 1,304Q, 1,305F
CDD
cd07542 (P-type_ATPase_cation)

Protein sequence

>MCA_00962_1
MTGKNLKKKSDNAQESTNSNRRRSKSRSMSRSSSKRPNRSRRTSIAHSIQSSVMSDTEGEEIDEYLAEPASEEIFSGPVS
ESVPSAYSSFRHRRYSSRPPGSRRDSSVTRPSFDPDNDLSSSVNSRRSSLYNRSFFPSSSNNDAVSIHSVDSDTSIHRAR
AESFSAPAFRFFSQDEIEQAEGASTAPNEVDPVEYEVLRRETEEYMPEEEIPDFISATPHQHPYRYSYEESEFLLRQQEE
LEHAREIYEEEREEREEAIDGHQDESSRHHHYRKSIDSRRWSETEDAEEPLLSRITSRISQEPLPRPFTASKTYQQRFYI
SEEDMVIFIAGYCSSKLRAWLYYLLCICTFGLAFLILRWIPRWHVACLGIPAPLGQCDWVVVENQWGEISIINVKSKFFN
NPLSQVFRKKTEDDGETDENADSTGNSSRSSFQNHSIQNYHDDESDPDPKLHTLRIIEYRYIKFYYNPEEDIFLTNYDWV
DSSWKDIDQVRMGIDPDIQKTRLTVFGPNLIDIEEKSTFSLLIDEVLHPFYVFQVFSMILWSLDEYYYYATCIFIISVIS
VGNTLVETKQTMKRLRELARFVSDIRVLRSGYWITIPSTELIPGDIYEVSDPSITVFPCDSILLSGDCVVNESMLTGESV
PVSKYPASNSALDEYVNGPSQGSSISAEISKHFLYSGTKVVQVRKPVGISSHGDSNELDIAVAMVVRTGFMTTKGSLVRS
MLFPKPSDFKFYQDSFKYIGVMALVAVLGFSISIVDFIKMHMSKKLIIFRALDIITIVVPPALPATLTIGTNISLSRLRK
KKIFCISPSRVNVGGKLDIICFDKTGTLTEDGLDVLGIHALDSKGEFTPLLQTIEQVFPYENLDLSVDGKKATDIQQRSK
MISALTTCHLLRKIDGELLGDPLDHKMFSFTDWNFDEDEGSKKFSKDYTHEYPIPLTFPTATLSQFRSPVNTLGTIKSFD
FVPKLRRMSVLVKGLSSEGHNEPRSNISVYVKGAPEIMPEVCDESTFPPNYAELLHYYTHRGYRVIACATKTYDNSMTAN
EARALSRNEVESGLQFLGFIVFENRLKPSTTEAINQLNNAQIRTVMCTGDNVLTAISVAKECHIVNENNHVFVPRFEELP
EGVPFEEFNPIRWEDIDNRNIQLDPYTLAPDSRDGIFDSSQYVLAVTGDAFRYIVQFGSDKQLEEVLMKGAIFARMSPDE
KHELVEKLQSLDYTTGFCGDGANDVGALKAAHVGISLSEAEASVAAPFTSQVFEISCVLDVIKEGRSALVTSFSCFKYMS
LYSAIQFVTVSILYSLGSNLGDFQFLWIDLFLILPIAIVMAWCEPFPVLCVKRPTANLVSTKILVPLLGQIAILASFQIT
IWKLVRKVPYYTPPIMGGDDSHVDSTDNTALFIFSCFQYIFISLLLTVGPPYHAPVSKNIPFVVTLIVSSLLTLGFMFVP
PDSWVGRLMNLTQLDWKFNTFMVCAIVVNFFVSKIANDYIFSTLAVWMRRFAIAFNLPAKTCSSKLYKRILESEKLPKEA

GO term prediction

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0000166 nucleotide binding
GO:0016887 ATPase activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features