MCA_00910_1

Protein

Length

1,730 amino acids

Gene name: SNF2

Description: Transcription regulatory protein SNF2

Browser: contigA:2856369-2861710-

RNA-seq: read pairs 5377, FPKM 38.4, percentile rank 59.4% (100% = highest expression)

Protein function

Annotation:		SNF2	Transcription regulatory protein SNF2
KEGG:	K11786	STH1_SNF2	ATP-dependent helicase STH1/SNF2 [EC:3.6.4.-]
EGGNOG:	0PH8Z	FG07306.1	SNF2 family ATP-dependent chromatin-remodeling factor snf21
SGD closest match:	S000005816	SNF2	Transcription regulatory protein SNF2
CGD closest match:	CAL0000176922	SNF2	SWI/SNF catalytic subunit

Protein alignments

	%id	Aln length
MIA_02071_1	74.68%	1189	MIA_02071_1
A0A0J9XG31_GEOCN	67.82%	1181	Similar to Saccharomyces cerevisiae YOR290C SNF2 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation OS=Geotrichum candidum GN=BN980_GECA14s03134g PE=4 SV=1
UniRef50_A0A0J9XG31	67.82%	1181	Similar to Saccharomyces cerevisiae YOR290C SNF2 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XG31_GEOCN
A0A060TIA1_BLAAD	62.43%	1203	ARAD1D44968p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D44968g PE=4 SV=1
A0A167CPD8_9ASCO	61.18%	1185	SWI/SNF catalytic subunit SNF2 OS=Sugiyamaella lignohabitans GN=SNF2 PE=4 SV=1
Q6C828_YARLI	59.32%	1116	YALI0D23287p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23287g PE=4 SV=1
A0A1E3PMW1_9ASCO	65.36%	941	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_33521 PE=4 SV=1
A0A1E4TJU7_9ASCO	63.73%	918	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22566 PE=4 SV=1
A0A1D8PGK4_CANAL	62.03%	906	SWI/SNF catalytic subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SNF2 PE=4 SV=1
SNF2_YEAST	59.76%	927	Transcription regulatory protein SNF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SNF2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0300

Protein family membership

None predicted.

Domains and repeats

Domain
259 - 295
Glutamine-Leucine-Glutamine, QLQ (IPR014978)
575 - 647
Helicase/SANT-associated domain (IPR014012)
760 - 1,045
SNF2-related, N-terminal domain (IPR000330)
1,069 - 1,233
Helicase, C-terminal (IPR001650)
1,280 - 1,350
Snf2, ATP coupling domain (IPR029295)
1,467 - 1,606
Bromodomain (IPR001487)
Domain
705 - 975
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
977 - 1,247
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
744 - 936
Helicase superfamily 1/2, ATP-binding domain (IPR014001)

1 200 400 600 800 1000 1200 1400 1600 1730

Detailed signature matches

IPR014978

Glutamine-Leucine-Glutamine, QLQ
1. PS51666 (QLQ)
  
  260 - 295
  
  PROSITE profiles
  PS51666 (QLQ)
2. SM00951 (QLQ_2)
  
  259 - 295
  
  SMART
  SM00951 (QLQ_2)
IPR014012

Helicase/SANT-associated domain
1. PS51204 (HSA)
  
  575 - 647
  
  PROSITE profiles
  PS51204 (HSA)
2. PF07529 (HSA)
  
  578 - 646
  
  Pfam
  PF07529 (HSA)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  705 - 975
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  977 - 1,247
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  760 - 925
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  744 - 936
  
  SMART
  SM00487 (ultradead3)
IPR000330

SNF2-related, N-terminal domain
1. PF00176 (SNF2_N)
  
  760 - 1,045
  
  Pfam
  PF00176 (SNF2_N)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  1,072 - 1,233
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,098 - 1,182
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,069 - 1,182
  
  Pfam
  PF00271 (Helicase_C)
IPR029295

Snf2, ATP coupling domain
1. PF14619 (SnAC)
  
  1,281 - 1,350
  
  Pfam
  PF14619 (SnAC)
2. SM01314 (SnAC_2)
  
  1,280 - 1,350
  
  SMART
  SM01314 (SnAC_2)
IPR001487

Bromodomain
1. PR00503 (BROMODOMAIN)
  
  1,526 - 1,542
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,560 - 1,579
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,542 - 1,560
  
  PRINTS
  PR00503 (BROMODOMAIN)
2. SSF47370 (Bromodomain)
  
  1,467 - 1,599
  
  SUPERFAMILY
  SSF47370 (Bromodomain)
3. SM00297 (bromo_6)
  
  1,487 - 1,598
  
  SMART
  SM00297 (bromo_6)
4. PS50014 (BROMODOMAIN_2)
  
  1,509 - 1,579
  
  PROSITE profiles
  PS50014 (BROMODOMAIN_2)
5. G3DSA:1.20.92...
  
  1,480 - 1,606
  
  GENE3D
  G3DSA:1.20.920.10 (G3DSA:1.20.920.10)
6. PF00439 (Bromodomain)
  
  1,513 - 1,583
  
  Pfam
  PF00439 (Bromodomain)
IPR018359

Bromodomain, conserved site
1. PS00633 (BROMODOMAIN_1)
  
  1,514 - 1,571
  
  PROSITE patterns
  PS00633 (BROMODOMAIN_1)

no IPR

Unintegrated signatures

Coil

628 - 648

COILS
Coil (Coil)

704 - 724

COILS
Coil (Coil)
G3DSA:3.40.50...

712 - 974

GENE3D
G3DSA:3.40.50.10810 (G3DSA:3.40.50.10810)
G3DSA:3.40.50...

1,054 - 1,220

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00046 (DEXDc)

768 - 907

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,057 - 1,190

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

1 - 91

MobiDB Lite
mobidb-lite (disorder_prediction)

1,595 - 1,653

MobiDB Lite
mobidb-lite (disorder_prediction)

1,346 - 1,419

MobiDB Lite
mobidb-lite (disorder_prediction)

303 - 403

MobiDB Lite
mobidb-lite (disorder_prediction)

1,679 - 1,730

MobiDB Lite
mobidb-lite (disorder_prediction)

137 - 259

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

776G

ATP binding site
776G, 777L, 778G, 779K, 780T
CDD
cd00046 (DEXDc)

777L

ATP binding site
776G, 777L, 778G, 779K, 780T
CDD
cd00046 (DEXDc)

778G

ATP binding site
776G, 777L, 778G, 779K, 780T
CDD
cd00046 (DEXDc)

779K

ATP binding site
776G, 777L, 778G, 779K, 780T
CDD
cd00046 (DEXDc)

780T

ATP binding site
776G, 777L, 778G, 779K, 780T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

875D

putative Mg++ binding site
875D, 876E, 877G, 878H
CDD
cd00046 (DEXDc)

876E

putative Mg++ binding site
875D, 876E, 877G, 878H
CDD
cd00046 (DEXDc)

877G

putative Mg++ binding site
875D, 876E, 877G, 878H
CDD
cd00046 (DEXDc)

878H

putative Mg++ binding site
875D, 876E, 877G, 878H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,092Q

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,093M

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,094T

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,095Q

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,115D

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,116G

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,144T

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,145R

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)

1,146A

nucleotide binding region
1,092Q, 1,093M, 1,094T, 1,095Q, 1,115D, 1,116G, 1,144T, 1,145R, 1,146A
CDD
cd00079 (HELICc)
ATP-binding site c...

1,152N

ATP-binding site
1,152N, 1,173Q, 1,177R, 1,180R
CDD
cd00079 (HELICc)

1,173Q

ATP-binding site
1,152N, 1,173Q, 1,177R, 1,180R
CDD
cd00079 (HELICc)

1,177R

ATP-binding site
1,152N, 1,173Q, 1,177R, 1,180R
CDD
cd00079 (HELICc)

1,180R

ATP-binding site
1,152N, 1,173Q, 1,177R, 1,180R
CDD
cd00079 (HELICc)

Protein sequence

>MCA_00910_1
MVNQQQNQFQQQQQHFYQSSQPSFALPNSPVQGNLNQPHSSPIQQQQPQQQFQQLNQPFQNPTMSNTASSTTPLINQHHS
NTQGQQAPFVPPYSIQSKEDLQKCATRWSQIRKELGNEANNNVEFMALSKILSDFHRTQQRRASQQNQQTQAQSSNQPQS
IQNQQQPQQHQQPQQQHQPQQHMNQMNINQPNQNNNVSFRPQQPQQPLSQPQIQQQQSQQHLRSNTPLSSAASPVTNPQM
NLNSSNNSLSNSPNSQNLQLFSPDQQALFKNQIIAFKSLMKNKQIPPQIQNQLFNPNVTSAFQVQQPQGHRSTSNSGSIP
PQPISRVPSSTGIHTPQQIHSRNPSATPDLPNNANPQISNPNSPGIMSRNQSIASQSPAPTNASPPAIQQLPQTQQTSQQ
LVRKDSVPIQTTPLEPPPPKTLYEKLGVSGYVDPESYLPEYLDISKPPAELSDDVSFIPSLMPLGVNIAKIKNLREMDIN
TKIFNRLVELYPKVEPLLQAEADKVPLTEEQLSMLIEFKSLTLLNKQKALRGDILADMYYFNTVRMNETSQIFYTRMKQT
TIQECLITEKFDVDQRTQRKLRENQLKREYLKNTCAHAKSIKAHEINNGEKRRKFGRNIMSFHSFTEKEEQKRAERTAKQ
RLQALKANDEEAYIKLLDQTKDTRITHLLKQTNSFLDSLAQAVKNQQRETMSIATDADDGTNKIEELDNNEEDEVEEVDK
EKIDYYAVAHRIKETVTKQPSILVGGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLIEVKKVHGPY
LVIVPLSTLTNWTLEFERWAPSVKKVVYKGPPLARRSQQAIIKSGDFQVVLTTYEYVIKDRPLLSKIKWVHMIIDEGHRM
KNTQSKLSYTLTTYYSTKYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKMGLSEEETLLI
IRRLHKVLRPFLLRRLKKDVEKDLPDKVEKVLKCKMSALQTSLYQQILRFKKMFIGDGKGNNPNSAKGLNNKLMQLKKVC
NHPFVFEPVEHLINPTQLNNALLWRTAGKFELLDRVLPKFHATNHRVLIFFQMTQIMDIMEDFMRLLGYQYLRLDGGTKA
DERSDLLKKFNAPDSPYFAFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQTKEVRILRLITENSVEE
HILDRAHKKLDIDGKVIQAGKFDNKSTNEEQEAFLRHLLEQEELKRLHKNEEEEELDDDELNEILARNDEERLIFRKIDE
EREAKCPYGKGKQFDRLFSEAELPETYKEEFLKKEEMAEPEVVDHNQYGRGARERKVTHYDDGLTEEQWLEAMDNDDDTP
EEATARKRARIEKRRANKLKRENDRGSNGTNTPRGNSVGAYSRSPSYADPSSPTPFLEPSKVVGDLVAAVNSGVKRKRGR
KSKADSEAVAAASAAALSDALVAPIPLRKKSKGRPPKVKETLTPEARLDLTNKMCALYNHILSLKDEETGRSRVDLFMEL
PSKRLYADYYVLIQNPIAMDIINKRINNRTYQRLGEFRADFQLMFDNARKYNTEGSLIYEDANIMEKEFNKKLNELLPGN
SDDASKVSSNTGEDNNNKPESFPNGGSAIMNKGIDGIMTSTSSNGSTTSLPADSLNSMNSSAFSIDTNKDVKISEGTIPN
QVSLTNGSIQGQQQLNGGGQGSSEDEDDEPISTKKRKSNDNFLVDEDDED

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042393 histone binding

Cellular Component

GO:0005634 nucleus

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Entry type

Status

Per-residue features