Protein

MCA_00860_1

Length
645 amino acids

Gene name: EPS1

Description: ER-retained PMA1-suppressing protein 1

Browser: contigA:2718222-2720160-

RNA-seq: read pairs 3153, FPKM 60.3, percentile rank 69.4% (100% = highest expression)

Protein function

Annotation:EPS1ER-retained PMA1-suppressing protein 1
KEGG:K13996EPS1 protein disulfide-isomerase [EC:5.3.4.1]
EGGNOG:0PJ6RFG06174.1disulfide isomerase
SGD closest match:S000001267EPS1ER-retained PMA1-suppressing protein 1
CGD closest match:CAL0000180758orf19.1392Protein disulfide isomerase

Protein alignments

%idAln lengthE-value
MIA_02030_155.86%6230.0MIA_02030_1
A0A0J9XIP9_GEOCN46.07%6620.0Similar to Saccharomyces cerevisiae YIL005W EPS1 ER protein with chaperone and co-chaperone activity,involved in retention of resident ER proteins OS=Geotrichum candidum GN=BN980_GECA20s00560g PE=4 SV=1
UniRef50_A0A0J9XIP946.07%6620.0Similar to Saccharomyces cerevisiae YIL005W EPS1 ER protein with chaperone and co-chaperone activity,involved in retention of resident ER proteins n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIP9_GEOCN
A0A167FWW9_9ASCO37.07%6343e-125Protein disulfide isomerase EPS1 OS=Sugiyamaella lignohabitans GN=EPS1 PE=4 SV=1
A0A1E4TBH3_9ASCO29.87%6936e-80Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32396 PE=4 SV=1
Q6C7A3_YARLI27.94%6129e-67YALI0E02420p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E02420g PE=4 SV=1
A0A060T8M7_BLAAD27.27%6162e-65ARAD1D08382p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D08382g PE=4 SV=1
A0A1E3PFI4_9ASCO27.03%5294e-43Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83739 PE=4 SV=1
A0A1D8PII5_CANAL24.62%2642e-18Protein disulfide isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1392 PE=4 SV=1
EPS1_YEAST21.77%4646e-16ER-retained PMA1-suppressing protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EPS1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0854
Predicted cleavage: 15

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 645

Detailed signature matches

  1. Domain IPR012336
    Thioredoxin-like fold
    1. SSF52833 (Thioredox...)
  2. Domain IPR013766
    Thioredoxin domain
    1. PF00085 (Thioredoxin)
    2. PS51352 (THIOREDOXIN_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:3.40.30.10
  4. NON_CYTOPLASM... (N...)
  5. PF13848 (Thioredoxin_6)
  6. SFLDG00345 (PDI-like)
  7. SIGNAL_PEPTIDE (Sig...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SignalP-noTM
  12. TMhelix
  13. TRANSMEMBRANE (Tran...)
  14. cd02961 (PDI_a_family)
  15. mobidb-lite (disord...)

Residue annotation

  1. catalytic residues...
  2. catalytic residues...

Protein sequence

>MCA_00860_1
MILIRFFTLLAAVFLFTTYAAPVEDEKLTPPELTGENFDETTAKGIWWIKYYSPYCHHCKTFAPIWNSLYAKLKDNNDDL
HFASVNCVSQGDLCSRKDVGVYPTINLYKDGLLMENQKGIKSASVMEKFIANALKEFAENDAKKEVSTKTEANDGKSASP
TDTKNTETKSGSFPTFPHSTEIVNTKYPDSVIPATKLSGDVPNPKGLSVPLDYKEFTRRVTATRNGWFIQFYSSKSRHSR
DLSPAWNQLAREAKGKLNIGHVNCDVEKRLCKNANISEYPTLKYFASSIQTEYKGLRGIGDLLHFLKCAVEVHSPRSIDF
LQYQQLLKGSEDVTLLYIYDHNTAMEDFQAFEKLGAAIIGTVEMAITNDTRIIGDLKEAQLPALYAISKDKSVRFPAKTS
ESIRKHNDLVDWATRNRLPLVPQLTPITAQDIFANSVVVLALLDPREEADTASAIKELKAVAQELQALKEKEEREELEEL
RKKKQLKIDEAKDKNDEAAEDRANEIVVEPTPRQPISVAWIDAVFWERWVRGRYGSYDGKSRVIINKENSGKFWDKTVSG
DVLVPSRSSIMETLEAALGSSSRLSPMPLHNSVSAYISQTRETLFANSYFYFFLGGAFIVTYLYKKHHGKKREGHATEGL
LGKLD

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis

Molecular Function

None predicted.

Cellular Component

None predicted.