Protein

MCA_00849_1

Length
656 amino acids

Gene name: GSH1

Description: Glutamate--cysteine ligase

Browser: contigA:2662273-2664347+

RNA-seq: read pairs 6889, FPKM 129.6, percentile rank 82.9% (100% = highest expression)

Protein function

Annotation:GSH1Glutamate--cysteine ligase
KEGG:K11204GCLC glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
EGGNOG:0PFP6FG09991.1glutamate-cysteine ligase
SGD closest match:S000003637GSH1Glutamate--cysteine ligase
CGD closest match:CAL0000193135GCS1Glutamate--cysteine ligase

Protein alignments

%idAln lengthE-value
A0A0J9X6S6_GEOCN76.07%6560.0Similar to Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis OS=Geotrichum candidum GN=BN980_GECA04s00351g PE=4 SV=1
MIA_02924_165.47%6400.0MIA_02924_1
A0A060T4F1_BLAAD64.42%6380.0ARAD1C40634p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C40634g PE=4 SV=1
A0A167EV99_9ASCO62.66%7070.0Glutamate--cysteine ligase OS=Sugiyamaella lignohabitans GN=GSH1 PE=4 SV=1
A0A1E4TIH1_9ASCO61.89%6770.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29900 PE=4 SV=1
Q6C433_YARLI60.34%6530.0YALI0E30129p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E30129g PE=4 SV=1
A0A1E3PCG0_9ASCO58.42%6590.0GCS-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53751 PE=4 SV=1
UniRef50_G7E2C458.03%6790.0Uncharacterized protein n=22 Tax=Dikarya TaxID=451864 RepID=G7E2C4_MIXOS
GSH1_YEAST47.51%7030.0Glutamate--cysteine ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GSH1 PE=1 SV=1
A0A1D8PE63_CANAL48.55%5501e-171Glutamate--cysteine ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GCS1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0013

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR004308
    Glutamate-cysteine ligase catalytic subunit
    1. PF03074 (GCS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SSF55931 (Glutamine...)
  8. TRANSMEMBRANE (Tran...)
  9. cd00164 (S1_like)
  10. mobidb-lite (disord...)

Residue annotation

  1. RNA binding site c...

Protein sequence

>MCA_00849_1
MGLLSLGTPLPWSEAKKYSAYVREQGIEQLIHIYNNAKSKHGDSLLWGDEVEYMVISKDDESRNARLSLRQAQILADLAI
QEEKGLLKEADVTFHPEYGRYMLEATPATPFTGSPHHLLSVEKNMAVRRSVAKSQMLPNEVPLTITSFPRLGTDQFTDPP
HPPTGNASRSFFLPDEIINPHARFPTLTANIRRRRGSKVAINVPLYFDKNTPKPFTHDPTIPYDRNLFPEDSNAREGAAL
PDHIYMDSMGFGMGCCCLQLTFQATDIQEARNLYDQLAPVAPIMLALTAASPFYRGYISDQDTRWNVIAGSVDDRTPYER
GLVPPPEGFTTDNSDVVIPKSRYDSLDSYLAIDDPALMANEAHYNDTKLVVNKKVLARLHEAGFDELLAKHFAHLFIRDP
IVIFEELLKQDNETSSDHFENIQSTNWQTMRFKPPPPGSDIGWRVEFRPMEVQFTDFENASFTIFIVLLTRVILSLNLNF
YIPISKIDENMKIAHHRGGILNEKFWFRTDITRPEDSSSSSDTDENNSEPSATPSIGPGNYEKLTIDEIINGKSDNSFPG
LIPMIRKYLHSINIDMETLCTLEKYLSLVSKRASGELVSNATWMRDFVRSHPAYKFDSVVSQEINYDLVNAIARLTDGQG
WNEDGKSTLGGFSPNF

GO term prediction

Biological Process

GO:0006750 glutathione biosynthetic process

Molecular Function

GO:0004357 glutamate-cysteine ligase activity

Cellular Component

None predicted.