Protein
MCA_00834_1
Length
485 amino acids
Gene name: TIM50
Description: Mitochondrial import inner membrane translocase subunit TIM50
Browser: contigA:2603373-2604831-
RNA-seq: read pairs 4268, FPKM 108.5, percentile rank 80.1% (100% = highest expression)
Protein function
| Annotation: | TIM50 | Mitochondrial import inner membrane translocase subunit TIM50 | |
|---|---|---|---|
| KEGG: | K17496 | TIM50 | mitochondrial import inner membrane translocase subunit TIM50 |
| EGGNOG: | 0PGG7 | TIM50 | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex |
| SGD closest match: | S000005984 | TIM50 | Mitochondrial import inner membrane translocase subunit TIM50 |
| CGD closest match: | CAL0000183476 | TIM50 | Mitochondrial import inner membrane translocase subunit TIM50 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05776_1 | 66.88% | 477 | 0.0 | MIA_05776_1 |
| A0A0J9XFT1_GEOCN | 64.66% | 464 | 0.0 | Similar to Saccharomyces cerevisiae YPL063W TIM50 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex) OS=Geotrichum candidum GN=BN980_GECA14s00241g PE=4 SV=1 |
| A0A060T598_BLAAD | 58.00% | 450 | 2e-178 | ARAD1C03916p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03916g PE=4 SV=1 |
| A0A167FN24_9ASCO | 56.82% | 491 | 4e-173 | Tim50p OS=Sugiyamaella lignohabitans GN=TIM50 PE=4 SV=1 |
| UniRef50_A0A167FN24 | 56.82% | 491 | 1e-169 | Tim50p n=5 Tax=Saccharomycetales TaxID=4892 RepID=A0A167FN24_9ASCO |
| A0A1E3PLQ3_9ASCO | 53.02% | 464 | 9e-158 | NIF-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82133 PE=4 SV=1 |
| TIM50_YARLI | 49.42% | 431 | 6e-142 | Mitochondrial import inner membrane translocase subunit TIM50 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIM50 PE=3 SV=1 |
| TIM50_CANAL | 45.05% | 475 | 4e-123 | Mitochondrial import inner membrane translocase subunit TIM50 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIM50 PE=3 SV=1 |
| TIM50_YEAST | 44.09% | 474 | 2e-111 | Mitochondrial import inner membrane translocase subunit TIM50 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIM50 PE=1 SV=1 |
| A0A1E4TBL4_9ASCO | 45.51% | 345 | 9e-100 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20435 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9994
Predicted cleavage: 45
Protein family membership
None predicted.
Domains and repeats
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Domain
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Domain
1
50
100
150
200
250
300
350
400
450
485
Detailed signature matches
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SSF56784 (HAD-like)
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no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
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cd07521 (HAD_FCP1-like)
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mobidb-lite (disord...)
Residue annotation
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active site cd07521
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HAD signature moti...
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HAD signature moti...
Protein sequence
>MCA_00834_1 MSQVIRSLARASARAVFNPRASNVVFRSVASNNALKFATRARFYSDKPNKPSSLLSDDILEKAGMEVNSQSSKASAETSE STESSSSSTESSTEGHTTEEQRQRWKGTAKKASNKTTKDLHREKLSNYFYVAALGAALGGSIYLARDWDNEEEQNRHPDI GNGMSASLLWGRFSARIGDLFGYFNEPVFEELLPDPLPAPYGRPFTLVLGLDDVLVHSEWSRQYGWRTAKRPGLDYFLGY LAQYYEIVVFSSNYMMNSEKIIPKLDPYRASISHALYRESTTYRDGKIIKDLGRMNRDIGKIIMVDCSPDSAALQPENAI ILKPWEGNADDKELVKLIPFLEWLATQPIKDVRPILKSYEGTYIPDEYSRREAIVRKKFEEEWQAEQAQRQKNNWAAQFL GIKPPTQTAPMMPQDYIRQEGQKGYLQFQKYVEEHGEEFLAEEKAREQQIMNEQKLTLNKLVTQGLPTPEEIQAAAAAAE ANNKQ
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.