Protein
MCA_00755_1
Length
893 amino acids
Gene name: MNL1
Description: ER degradation-enhancing alpha-mannosidase-like protein 1
Browser: contigA:2364670-2367413+
RNA-seq: read pairs 579, FPKM 8.0, percentile rank 22.4% (100% = highest expression)
Protein function
| Annotation: | MNL1 | ER degradation-enhancing alpha-mannosidase-like protein 1 | |
|---|---|---|---|
| KEGG: | K10084 | EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 |
| EGGNOG: | 0PHKG | MNL1 | hydrolase family 47 protein |
| SGD closest match: | S000001247 | MNL1 | ER degradation-enhancing alpha-mannosidase-like protein 1 |
| CGD closest match: | CAL0000199621 | orf19.834 | alpha-1,2-Mannosidase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04420_1 | 56.02% | 798 | 0.0 | MIA_04420_1 |
| A0A0J9X2U9_GEOCN | 64.00% | 475 | 0.0 | alpha-1,2-Mannosidase OS=Geotrichum candidum GN=BN980_GECA01s05653g PE=3 SV=1 |
| UniRef50_A0A0J9X2U9 | 64.00% | 475 | 0.0 | alpha-1,2-Mannosidase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2U9_GEOCN |
| A0A167E7G0_9ASCO | 60.98% | 492 | 0.0 | alpha-1,2-Mannosidase OS=Sugiyamaella lignohabitans GN=MNL1 PE=3 SV=1 |
| A0A060TEE6_BLAAD | 57.23% | 505 | 0.0 | alpha-1,2-Mannosidase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D14608g PE=3 SV=1 |
| A0A1E3PNG0_9ASCO | 56.58% | 486 | 0.0 | alpha-1,2-Mannosidase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_8473 PE=3 SV=1 |
| A0A1E4TLJ1_9ASCO | 52.36% | 466 | 3e-164 | alpha-1,2-Mannosidase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1221 PE=3 SV=1 |
| Q6C995_YARLI | 49.59% | 488 | 4e-148 | alpha-1,2-Mannosidase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12925g PE=3 SV=1 |
| MNL1_YEAST | 45.15% | 485 | 2e-123 | ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MNL1 PE=1 SV=1 |
| A0A1D8PH01_CANAL | 40.75% | 562 | 9e-112 | alpha-1,2-Mannosidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.834 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0313
Protein family membership
- Glycoside hydrolase family 47 (IPR001382)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
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NON_CYTOPLASM... (N...)
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SIGNAL_PEPTIDE (Sig...)
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SIGNAL_PEPTID... (S...)
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SIGNAL_PEPTID... (S...)
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SIGNAL_PEPTID... (S...)
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Protein sequence
>MCA_00755_1 MALILYLIAFIFDFLSGTCAIASQKPAEFSSTILKELREEAKSMFYHGWENYLNAAFPDDELRPLTCDGLTKDENDPTNI GLNDVLGGYSVTLIDSLDMFPILNDQEGFERNVDRVRKYVSFNISSTVQVFETTIRGLGGLLSAHLYASTPKLGHQIPGY DGFLLHLAYDLAERLLPSFNTTSGIPYPRINLKHGLEGAKVTKQEDPDITETCTSGAGSLVLEFGLLSRLTGDNRFEAAA KRAFFAIWARRSDLDLVAMAIDSKTGQWLAPMTGNGASIDSYYEYALKYYVLFGSSDFLNVYNKLHRALVSHSFDGWMFH NVNFQTSVRVTNWVDSLAAFYPSVMVLGGDLETAIKTHLAYYKIWNTYSALPERWDAIRNYYLERRSRPSSVNLEWYPLR PEFVESNYYLYKATKDPFFMNIGRSVMEDLQKQNKVACGYAGIQDVNTGTLSNRMESFFLSETTKYLYLLFDDEHPLNNE FSNFVFSTEAHPFWFDKSVMLSAAANKFPAIAHIWKGENDNNKALESNGNISRNPNHQKQELLSDEEKEMIREYIAEQNR PFYENLGVSVMWGDWRGRSTKRYQASKIGKLLRSFIFHLRVLNQKVFSFIFSFALNNTEKSNDHIITSNSATSLNELEPI TPTDLDSTLDKDASYQRSIMDGKNVRNNSTTVKNYPKLSFSYLNQCEVWNPQKLLGIPSNQTLTLGSGLYSYISSWGEFY RLNGLYIYNKPDHLKDYTEFEYRHGFSDRFTSPDSICEKPRIFKDMEIMILTPRGSRKGTVLSRSIDGNVEVTNLNGMRM TIRKKAKNRLLKNELSPSYSQFKTSRENDKDSESTIHDLYDIKILDGVKIDNNVTVQSLLLSQSDNSVVSITSEGKVKID KYIIDNMNVLKVK
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Cellular Component
GO:0016020 membrane