MCA_00734_1

Protein

Length

2,079 amino acids

Gene name: FAS1

Description: Fatty acid synthase subunit beta

Browser: contigA:2287687-2293927+

RNA-seq: read pairs 33381, FPKM 198.3, percentile rank 87.9% (100% = highest expression)

Protein function

Annotation:		FAS1	Fatty acid synthase subunit beta
KEGG:	K00668	FAS1	fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
EGGNOG:	0Q0WA	FAS1	fatty acid synthase
SGD closest match:	S000001665	FAS1	Fatty acid synthase subunit beta
CGD closest match:	CAL0000183162	FAS1	Tetrafunctional fatty acid synthase subunit

Protein alignments

	%id	Aln length
MIA_05440_1	82.12%	2081	MIA_05440_1
A0A0J9XBS8_GEOCN	77.03%	2077	Similar to Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase OS=Geotrichum candidum GN=BN980_GECA08s03893g PE=4 SV=1
A0A060T4D9_BLAAD	72.26%	2080	ARAD1A16258p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16258g PE=4 SV=1
A0A167D8A8_9ASCO	72.44%	2083	Tetrafunctional fatty acid synthase subunit FAS1 OS=Sugiyamaella lignohabitans GN=FAS1 PE=4 SV=1
A0A1E3PLT4_9ASCO	67.16%	2092	S-acyl fatty acid synthase thioesterase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=FAS1 PE=4 SV=1
FAS1_YARLI	65.66%	2091	Fatty acid synthase subunit beta OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=FAS1 PE=3 SV=2
UniRef50_K0KL43	62.62%	2076	Fatty acid synthase n=39 Tax=saccharomyceta TaxID=716545 RepID=K0KL43_WICCF
Q5A4W7_CANAL	62.09%	2068	Tetrafunctional fatty acid synthase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FAS1 PE=4 SV=1
A0A1E4TI19_9ASCO	60.73%	2096	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32053 PE=4 SV=1
FAS1_YEAST	58.93%	2072	Fatty acid synthase subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAS1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0378

Protein family membership

Fatty acid synthase, beta subunit, fungi (IPR016452)

Domains and repeats

Domain
167 - 327
Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
435 - 536
Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
1,029 - 1,085
Domain of unknown function DUF1729 (IPR013565)
1,309 - 1,438
HotDog domain (IPR029069)
1,546 - 1,683
HotDog domain (IPR029069)
MaoC-like domain (IPR002539)
1,690 - 2,063
Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035)
Acyl transferase (IPR014043)
Polyketide synthase, acyl transferase domain (IPR020801)
Domain
170 - 397
Starter unit:ACP transacylase (IPR032088)
571 - 1,105
Aldolase-type TIM barrel (IPR013785)
Domain
590 - 610
Fatty acid synthase (IPR003965)
616 - 634
Fatty acid synthase (IPR003965)
715 - 733
Fatty acid synthase (IPR003965)
735 - 754
Fatty acid synthase (IPR003965)
923 - 941
Fatty acid synthase (IPR003965)
1,023 - 1,047
Fatty acid synthase (IPR003965)
1,572 - 1,594
Fatty acid synthase (IPR003965)
1,594 - 1,615
Fatty acid synthase (IPR003965)
1,680 - 1,699
Fatty acid synthase (IPR003965)
1,701 - 1,724
Fatty acid synthase (IPR003965)
1,823 - 1,842
Fatty acid synthase (IPR003965)
1,859 - 1,880
Fatty acid synthase (IPR003965)

1 200 400 600 800 1000 1200 1400 1600 1800 2079

Detailed signature matches

IPR016452

Fatty acid synthase, beta subunit, fungi
1. PIRSF005562 (FAS_ye...)
  
  11 - 2,077
  
  PIRSF
  PIRSF005562 (FAS_yeast_beta)
IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase
1. SSF52151 (FabD/lyso...)
  
  1,796 - 1,872
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
  
  1,690 - 1,741
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
  
  2,001 - 2,047
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
  
  435 - 536
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
  
  167 - 327
  
  SUPERFAMILY
  SSF52151 (FabD/lysophospholipase-like)
IPR032088

Starter unit:ACP transacylase
1. PF16073 (SAT)
  
  170 - 397
  
  Pfam
  PF16073 (SAT)
IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  571 - 1,105
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR003965

Fatty acid synthase
1. PR01483 (FASYNTHASE)
  
  1,823 - 1,842
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,701 - 1,724
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  735 - 754
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,023 - 1,047
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  715 - 733
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,680 - 1,699
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  616 - 634
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,594 - 1,615
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,859 - 1,880
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  590 - 610
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  1,572 - 1,594
  
  PRINTS
  PR01483 (FASYNTHASE)
  
  923 - 941
  
  PRINTS
  PR01483 (FASYNTHASE)
IPR013565

Domain of unknown function DUF1729
1. PF08354 (DUF1729)
  
  1,029 - 1,085
  
  Pfam
  PF08354 (DUF1729)
IPR029069

HotDog domain
1. SSF54637 (Thioester...)
  
  1,309 - 1,438
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
  
  1,571 - 1,683
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
IPR002539

MaoC-like domain
1. PF01575 (MaoC_dehyd...)
  
  1,546 - 1,673
  
  Pfam
  PF01575 (MaoC_dehydratas)
IPR014043

Acyl transferase
1. PF00698 (Acyl_transf_1)
  
  1,690 - 2,063
  
  Pfam
  PF00698 (Acyl_transf_1)
IPR020801

Polyketide synthase, acyl transferase domain
1. SM00827 (PKS_AT)
  
  1,691 - 2,045
  
  SMART
  SM00827 (PKS_AT)

no IPR

Unintegrated signatures

G3DSA:3.10.12...

1,308 - 1,454

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)

1,567 - 1,686

GENE3D
G3DSA:3.10.129.10 (G3DSA:3.10.129.10)
G3DSA:3.40.36...

162 - 534

GENE3D
G3DSA:3.40.366.10 (G3DSA:3.40.366.10)

1,687 - 1,977

GENE3D
G3DSA:3.40.366.10 (G3DSA:3.40.366.10)
PF13452 (MaoC_dehyd...)

1,304 - 1,428

Pfam
PF13452 (MaoC_dehydrat_N)
cd03447 (FAS_MaoC)

1,565 - 1,686

CDD
cd03447 (FAS_MaoC)

Residue annotation

putative active si...

1,579A

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,584D

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,586N

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,589H

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,604I

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,607G

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)

1,608M

putative active site
1,579A, 1,584D, 1,586N, 1,589H, 1,604I, 1,607G, 1,608M
CDD
cd03447 (FAS_MaoC)
putative catalytic...

1,584D

putative catalytic site
1,584D, 1,586N, 1,589H, 1,607G
CDD
cd03447 (FAS_MaoC)

1,586N

putative catalytic site
1,584D, 1,586N, 1,589H, 1,607G
CDD
cd03447 (FAS_MaoC)

1,589H

putative catalytic site
1,584D, 1,586N, 1,589H, 1,607G
CDD
cd03447 (FAS_MaoC)

1,607G

putative catalytic site
1,584D, 1,586N, 1,589H, 1,607G
CDD
cd03447 (FAS_MaoC)

Protein sequence

>MCA_00734_1
MQPATGFSTPHSAASLRPLNLVHGSIEHTILVPTSLYLNCSQLRDQFYTTLPTPTEDYVGDDEPTCPTELLAAFLGYAAE
IVSDEPGPFDEVLPVILTEFETRFLHGNNVHAVATALQSSPDSNTTTQKVAKIVRSYYSARIAANRPIKSHESALFRAVE
DKQATLYAIFGGQGNTEDYFDELREIYSTYGDLISDYIQLLADKLLSLSRTHKDTNKIFTNGLDVMAWLKNPDATPDIDY
LIYAPVSVPIIGIIQLAHFATTARVLGKTPGEIRDYFSGATGHSQGLVSAATVASSSSWESFYEESLKAMTILFYIGVYV
QRQYPNTSLPPSLLEDSIAEGEGKPYPMLSVRDLTRPQLESFIETTNKHLPKEKHISISLVNGARNMVVTGPPQSLYGLN
LTLRKAKAPSGLNQGRVPHSERKLRISNKFLPVTSPFHSHLLNGATELVVKELAAAGISYKASDMKIPVFDTYDGTDLRE
NSNIVHRIVDLINFWPVNWEIATKFTATHIVDFGPGGVSGLGPLTHRNKEGTGVRVIIAGVLDGSLPNDEYGYKQELFDR
DSKSVKYAIDWVKEFSPKLVSTTDRVYVDTKFSRLLGRPPIMVPGMTPTTIHPEFVADTLNAGYHIELAGGGYFDPKIMT
KAIEKIENSTAPGVGITINLIYVNPFMMNWGIPLIKTLRQKGYPIEGLTIGAGVPSPDVANEYVRDLGLKHLSLKPGSVD
AINQVIQIAAANPHFPIVLQWTGGRGGGHHSFEDFHAPIFQTYARIRRQPNLILVAGSGFGSDKDSYPYLTGEWSTKYNY
PPMPFDGVLFGSRVMVAKEAFTSPAAKRAIVEAPGVEDKDWEKTYKGPTGGVITVLSEMGEPIHKLATRGVLFWHELDNT
IFNLPKNKRLEALKSKRAYIIKRLNDDSQKTWFGRNSAGETCDLEDMTYAEVISRCVELCYVKKEKRWIDVSLRGFTGDF
IRRVEERFTSSDGQQAVLQSYSQLEQPEEVLKALFERYPKATTQIINAQDKDHFLILCRRPTQKPVPFVPVLDDNFEFYF
KKDSLWQSEDLAAVVGEDVGRTCILQGPVAVRWSTEVDVPIKTILDGIHDGIIDSLLKDSYQGQKSKIPVTESFGLRLTA
SASELESRLGSNASIIKGSGDSISYKISTSESSLPSVNDWVELIVADKPGWFKALLTADIIVQGTKHRANQIRQLFTPVK
GLEVDVTNASSKDKLTVSITELINGKRSEVVKITKVAKGLIKVELIEERNYLHAPVSLELLFNYRPEYAFAPIAEVMEDR
NERIKQFYWKSWFGDEPVDLDIDVTKTIDGGKTTVDGKAIGDFVHAVGNNCEAYVERPNRVTYAPMDFAIVTGWKAIIKA
IFPKVIDGDILKLVHLSNSFSMIPGAEPLQKGDVVTSTANLKSIINQENGKVVSVTGVISKDGKPVMEVTSEFFYRGDYN
DFENTFERKVEAPIQIQLATPKDVAVLCSKEWFQLNDPEIDLLGKTLTFRTESFFKFKNTNVYSSVETKGQVLLELPSKE
IIQIGAVEYEAGESHGNPVIDYLQRNGKTIEQPVNFENAIPLNSGELTLKSPSSNEPYANVSGDYNPIHVSRIFSTYANL
PGTITHGMYSSAAVRSLVEVWAAENIVSRVRAFKCSFVGMVLPNDEIEVKLEHVGMINGRKIIKVECVNKETQVPVLSGE
AEVDQPTSSYVFTGQGSQEQGMGMDLYESSPVAREVWDRADKHFINTYGFSIIDIVKNNPKELTVHFGGPKGKAIRENYI
SMMFESIDENGQVKSEKIFKEITENTDFYTFTSPTGLLSATQFTQPALTLMEKASFEDMKAKGLVAADSTFAGHSLGEYS
ALASLGDVMPIESLVEVVFYRGMTMQVAVPRDSLGRSNYGMCAVNPSRISKSFDDAALRFVVDHISQQTKWLLEIVNYNV
ENTQYVAAGDLRALDTLTNVLNLLKVQKIDIVKLQETMSVEKVKEHLNEIVDEVSKQSLAKPQPIDLERGFAVIPLKGIS
VPFHSSYLRGGVKPFQRFLVKKIPQSAVKPANLINKYIPNLTAKPFELTKEYFEDVYKLTGSEKIKNVLDHWEEYESSA

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0004312 fatty acid synthase activity
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity

Cellular Component

GO:0005835 fatty acid synthase complex

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Entry type

Status

Per-residue features