Protein

MCA_00697_1

Length
412 amino acids

Gene name: POT1-2

Description: 3-oxoadipyl-CoA thiolase

Browser: contigA:2186468-2187707-

RNA-seq: read pairs 61, FPKM 1.8, percentile rank 11.4% (100% = highest expression)

Protein function

Annotation:POT1-23-oxoadipyl-CoA thiolase
KEGG:K07513ACAA1 acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
EGGNOG:0PHTR3-ketoacyl-coa thiolase
SGD closest match:S000001422POT13-ketoacyl-CoA thiolase, peroxisomal
CGD closest match:CAL0000175559POT1-2Pot1-2p

Protein alignments

%idAln lengthE-value
MIA_06253_184.95%4120.0MIA_06253_1
UniRef50_G1X5K564.30%4230.0Uncharacterized protein n=3 Tax=Orbiliaceae TaxID=47021 RepID=G1X5K5_ARTOA
A0A167DFK5_9ASCO65.61%4100.0Acetyl-CoA C-acyltransferase OS=Sugiyamaella lignohabitans GN=POT1 PE=3 SV=1
Q5AD21_CANAL59.41%4042e-167Pot1-2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POT1-2 PE=3 SV=1
A0A060TEZ7_BLAAD60.83%4113e-166ARAD1D18480p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D18480g PE=3 SV=1
A0A0J9XDV0_GEOCN48.16%4071e-112Similar to Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids OS=Geotrichum candidum GN=BN980_GECA11s01451g PE=3 SV=1
A0A1E3PSS7_9ASCO47.17%4077e-112Peroxisomal 3-oxoacyl-CoA thiolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48961 PE=3 SV=1
A0A1E4THP9_9ASCO46.80%4061e-108Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31916 PE=3 SV=1
THIK_YARLI48.90%4093e-1073-ketoacyl-CoA thiolase, peroxisomal OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=POT1 PE=3 SV=1
THIK_YEAST41.61%4117e-923-ketoacyl-CoA thiolase, peroxisomal OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POT1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8961
Predicted cleavage: 26

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 412

Detailed signature matches

  1. Family IPR002155
    Thiolase
    1. TIGR01930
    2. cd00751 (thiolase)
    3. PIRSF000429 (Ac-CoA...)
  2. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  3. Domain IPR020616
    Thiolase, N-terminal
    1. PF00108 (Thiolase_N)
  4. Domain IPR020617
    Thiolase, C-terminal
    1. PF02803 (Thiolase_C)
  5. SITE IPR020613
    Thiolase, conserved site
    1. PS00737 (THIOLASE_2)

Residue annotation

  1. dimer interface cd...
  2. active site cd00751

Protein sequence

>MCA_00697_1
MLRKGVSNILQKLPTDVVIASALRTPVTKAVKGGLAKMYPEELLATVLKGTLEMTKIDPSQVQDVLIGAVLQKLGGQKAS
AMAVKHVGFPYTTTINTINRQCSSSAQAASYLASNIRATNGEALNVAIAAGVESMSMDYFPHRGIPTRVSEVLKNSDYQE
AQDVLMPMGITSEIVAKEYGITREDQDAFGLLSQQKAAKAWESGHFDPEIVPVNARVFDKETGEVKEGEFQMITKDDGYR
KGLTLEKLAKLKPAFSEDGTTTAGNASQVSDGASAVLLMTRAKAEELGIKPIGKIVHSAVAGVPSRIMGIAPAKAIPVLL
NQLGLETKDIDIWELNEAFASQSLYCIRELGLDADKVNPFGGAIALGHPLGATGGRLIATLMNGLNALDKELGVVSMCAS
TGQGYAGLFVRE

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.