Protein

MCA_00608_1

Length
348 amino acids

Gene name: NUC1

Description: Mitochondrial nuclease

Browser: contigA:1864017-1865099+

RNA-seq: read pairs 3551, FPKM 125.7, percentile rank 82.5% (100% = highest expression)

Protein function

Annotation:NUC1Mitochondrial nuclease
KEGG:K01173ENDOG endonuclease G, mitochondrial
EGGNOG:0PHAYNUC1nuclease
SGD closest match:S000003744NUC1Mitochondrial nuclease
CGD closest match:CAL0000174323orf19.967Ribonuclease

Protein alignments

%idAln lengthE-value
MIA_01374_165.56%3604e-162MIA_01374_1
A0A0J9XFA4_GEOCN66.30%2733e-127Similar to Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease OS=Geotrichum candidum GN=BN980_GECA14s01231g PE=4 SV=1
A0A1E3PNZ2_9ASCO60.85%2813e-112Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49472 PE=4 SV=1
A0A167FA38_9ASCO61.25%2715e-121Nuc1p OS=Sugiyamaella lignohabitans GN=NUC1 PE=4 SV=1
A0A060T622_BLAAD62.12%2643e-117ARAD1C10384p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C10384g PE=4 SV=1
NUC1_YEAST59.85%2742e-115Mitochondrial nuclease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUC1 PE=1 SV=1
UniRef50_P0846659.85%2746e-112Mitochondrial nuclease n=91 Tax=Ascomycota TaxID=4890 RepID=NUC1_YEAST
Q5A4X9_CANAL59.70%2685e-110Ribonuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.967 PE=4 SV=1
Q6CA82_YARLI55.52%2812e-104YALI0D05071p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D05071g PE=4 SV=1
A0A1E4TK52_9ASCO54.04%2724e-100Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55788 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1189

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 348

Detailed signature matches

  1. Domain IPR001604
    DNA/RNA non-specific endonuclease
    1. SM00892 (Endonuclea...)
    2. PF01223 (Endonuclea...)
  2. Domain IPR020821
    Extracellular Endonuclease, subunit A
    1. SM00477 (endoplus)
  3. SITE IPR018524
    DNA/RNA non-specific endonuclease, active site
    1. PS01070 (NUCLEASE_N...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.57...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SSF54060 (His-Me fi...)
  8. SignalP-noTM
  9. cd00091 (NUC)
  10. mobidb-lite (disord...)

Residue annotation

  1. active site cd00091
  2. substrate binding ...
  3. Mg2+ binding site ...

Protein sequence

>MCA_00608_1
MVSFIIPTASFSIFVAGLMFWGKSSSSDNQPTEVATTVIPPANNDLPSLPTPPASPAGSFSAPLSGDGIPGSGLVKINAA
EFFEKYGHPGPVSDQAIRDEYISFFDRRTRNPYYVVEHITEESLKYVSNPPVDRKNSVFREDPAIPDTFKSKLRDYFRSG
FDRGHLAPAADAKFSQRAMDQTFFLSNMSPQVGEGFNRDYWSHFEYFCRNLTKDYKSVRVITGPLFLPQRGPDGISRVTY
QVIGDPPGVAVPTHFYKIIVGEQHIKSGGRPDSPVAVGAFVLPNSKIDNSAPLKSFAVPVSAIERATGLEFFTKLPQRNR
KELCQQVTCEIIVRDFNNAVKSLPPPKR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.