Protein
MCA_00572_1
Length
579 amino acids
Gene name: MIC60
Description: MICOS complex subunit MIC60; mitofilin
Browser: contigA:1766781-1768657-
RNA-seq: read pairs 14655, FPKM 312.2, percentile rank 92.0% (100% = highest expression)
Protein function
| Annotation: | MIC60 | MICOS complex subunit MIC60; mitofilin | |
|---|---|---|---|
| KEGG: | K17785 | IMMT | mitofilin |
| EGGNOG: | 0PFS9 | FCJ1 | Multifunctional regulator of mitochondrial architecture and protein biogenesis. May act in concert with ATP synthase dimers to generate inner membrane structure and consequently normal mitochondrial morphology. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity) |
| SGD closest match: | S000001724 | MIC60 | MICOS complex subunit MIC60 |
| CGD closest match: | CAL0000200955 | MIC60 | MICOS complex subunit MIC60 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01727_1 | 53.21% | 624 | 0.0 | MIA_01727_1 |
| A0A0J9X2J5_GEOCN | 45.25% | 495 | 1e-138 | MICOS complex subunit MIC60 OS=Geotrichum candidum GN=BN980_GECA01s02540g PE=3 SV=1 |
| UniRef50_A0A0J9X2J5 | 45.25% | 495 | 2e-135 | MICOS complex subunit MIC60 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2J5_GEOCN |
| A0A167EZW3_9ASCO | 51.92% | 364 | 4e-115 | MICOS complex subunit MIC60 OS=Sugiyamaella lignohabitans GN=MIC60 PE=3 SV=1 |
| MIC60_YARLI | 40.12% | 506 | 2e-108 | MICOS complex subunit MIC60 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MIC60 PE=3 SV=1 |
| A0A060THT5_BLAAD | 40.61% | 522 | 1e-105 | MICOS complex subunit MIC60 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D33990g PE=3 SV=1 |
| A0A1E3PRD5_9ASCO | 35.15% | 495 | 1e-103 | MICOS complex subunit MIC60 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_44672 PE=3 SV=1 |
| A0A1E4TBE1_9ASCO | 35.43% | 494 | 8e-80 | MICOS complex subunit MIC60 (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20184 PE=3 SV=1 |
| MIC60_CANAL | 29.30% | 512 | 3e-53 | MICOS complex subunit MIC60 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MIC60 PE=3 SV=2 |
| MIC60_YEAST | 37.69% | 130 | 8e-22 | MICOS complex subunit MIC60 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIC60 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9981
Predicted cleavage: 31
Protein family membership
- Mitochondrial inner membrane protein Mitofilin (IPR019133)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
-
CYTOPLASMIC_D... (C...)
-
-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
-
mobidb-lite (disord...)
Protein sequence
>MCA_00572_1 MLSRFASSSSQRALAKQLSSRPLLCSNAFTTTTALRASKVPGAGDFPPMVFEGKYIETPVVPKEVTQPPPPPPAFKTPPP PPPEVKPIIVEKKKSHFFRKLFLLTFGLTAIAYAGGVYYSLDDDNFRDIFTENVPLAEDIIYFIEEQRFKRRFSDKLPTI NSKTDAPPSLTSSKSTTVSRSGASPKPVDTEIKAPQEAAAPSAPPAHAKPNVTSATAQSIPKAQLPLIRITEDMNPTVEK SIEGINNFITLVNESKASPSDIEELSKVILELNSSIVNDVNKLSEAEVAKIEQKYEASLKEIKTAVSAQEEKWSRDFHEE TKRLTQAYNERLQNEVNAAQRVIFAHANNRLLAVHAEREKEFAKQISERVEKERNGRLSKLEEINKELQNVKELVSKASK AIEESNKASKYQLAVARLRLALDAEEPVPLEPYFSAVRNIDEKDEFISSVLSAVPKEALSQGVLSPAQIAARFHLLEPEI RNVSLLPPNAGVFGHLGSMVFSKLLWKKSGNATGDDVEAVLARAGTALSEGRIVDAVAEVNSLKGWPKRLAHDWLAEGRK RSEVEFLANLLAEEGKLWA
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.