Protein

MCA_00503_1

Length
534 amino acids

Gene name: MSY1

Description: Tyrosine--tRNA ligase, mitochondrial

Browser: contigA:1591507-1593196-

RNA-seq: read pairs 2390, FPKM 55.2, percentile rank 67.5% (100% = highest expression)

Protein function

Annotation:MSY1Tyrosine--tRNA ligase, mitochondrial
KEGG:K01866YARS tyrosyl-tRNA synthetase [EC:6.1.1.1]
EGGNOG:0PH73MSY1tyrosyl-tRNA synthetase
SGD closest match:S000006018MSY1Tyrosine--tRNA ligase, mitochondrial
CGD closest match:CAL0000176983orf19.109Tyrosine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_05807_161.30%5220.0MIA_05807_1
A0A0J9XJ15_GEOCN53.38%5170.0Tyrosine--tRNA ligase OS=Geotrichum candidum GN=BN980_GECA18s00593g PE=3 SV=1
A0A161HN82_9ASCO54.19%4543e-173Tyrosine--tRNA ligase OS=Sugiyamaella lignohabitans GN=MSY1 PE=3 SV=1
UniRef50_A0A161HN8254.19%4541e-169Tyrosine--tRNA ligase n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A161HN82_9ASCO
A0A060T3W9_BLAAD48.84%5181e-171Tyrosine--tRNA ligase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C37092g PE=3 SV=1
Q59WU2_CANAL47.69%4971e-149Tyrosine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.109 PE=3 SV=1
A0A1E3PQ19_9ASCO41.07%5041e-140Tyrosine--tRNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81843 PE=3 SV=1
A0A1E4TKN4_9ASCO40.32%5019e-129Tyrosine--tRNA ligase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84858 PE=3 SV=1
SYYM_YEAST41.19%4886e-125Tyrosine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSY1 PE=1 SV=1
Q6C474_YARLI36.65%5026e-104Tyrosine--tRNA ligase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E29139g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9775
Predicted cleavage: 44

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 534

Detailed signature matches

  1. Family IPR002305
    Aminoacyl-tRNA synthetase, class Ic
    1. PF00579 (tRNA-synt_1b)
  2. Family IPR002307
    Tyrosine-tRNA ligase
    1. TIGR00234
    2. cd00805 (TyrRS_core)
    3. PR01040 (TRNASYNTHTYR)
  3. Family IPR024107
    Tyrosine-tRNA ligase, bacterial-type, type 1
    1. MF_02006 (Tyr_tRNA_...)
  4. Domain IPR014729
    Rossmann-like alpha/beta/alpha sandwich fold
    1. G3DSA:3.40.50...
  5. Domain IPR002942
    RNA-binding S4 domain
    1. G3DSA:3.10.29...
  6. SITE IPR001412
    Aminoacyl-tRNA synthetase, class I, conserved site
    1. PS00178 (AA_TRNA_LI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.24...
  3. SSF52374 (Nucleotid...)

Residue annotation

  1. active site cd00805
  2. HIGH motif cd00805
  3. dimer interface cd...
  4. KMSKS motif cd00805

Protein sequence

>MCA_00503_1
MFLAKTAAGNLSKQFLISRSAISLKSPVFKVYNRRFYSSSESNNSLNPDLQVPLIEHLRERGLIESITNESISTLLEKEK
VSLYCGADPSANSLHVGNLIPLIILLHFRARGHNPIALVGGATGIVGDPSGRKTERQQMEAATRSNNVANIRKQLETFLT
RGEQYASKKGYPSSNFGKLQSTDNSNWWKNMGMLEFLGTYGRHIRVGQMLARDSVKSRMESEQGIGFNEFAYQILQAYDF
WHLHSTQGCKVQVGGNDQWGNITAGIDLITRLRSELFRKEKERKDLLKKNKNDKEVVEKLEAERDPIFDTLPIPSKEFEP
AYGITVPLLTTPSGEKFGKSAGNAVWIDPKLTKPYELYQYFVKAPDSIVEKYLKLFTFLPIESISELMEEHFKAPEAFKA
QKVLAKEVTDLVHGEGFGQESAIMSEILFPRNDSSTKSSGYNADTIISAFDRQDLVVRVPFKDIENVEWREFLSKLTGKS
KTNISQLLKTNSVYTGAELNPVQEKVITKDQLIENKLLLIRVGKKSFHLVEVTY

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm