Protein

MCA_00483_1

Length
325 amino acids

Gene name: CKA1B

Description: Casein kinase 2 catalytic subunit, a serine/threonine protein kinase with roles in cell growth and proliferation

Browser: contigA:1514459-1515642-

RNA-seq: read pairs 2630, FPKM 99.7, percentile rank 78.5% (100% = highest expression)

Protein function

Annotation:CKA1BCasein kinase 2 catalytic subunit, a serine/threonine protein kinase with roles in cell growth and proliferation
KEGG:K03097CSNK2A casein kinase II subunit alpha [EC:2.7.11.1]
EGGNOG:0PI5TCKA1casein kinase ii
SGD closest match:S000005587CKA2Casein kinase II subunit alpha'
CGD closest match:CAL0000178518CKA1Casein kinase 2 catalytic subunit

Protein alignments

%idAln lengthE-value
MIA_05916_175.24%3195e-171MIA_05916_1
A0A0J9XJC9_GEOCN72.67%3221e-165Similar to Saccharomyces cerevisiae YOR061W CKA2 Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation OS=Geotrichum candidum GN=BN980_GECA21s01330g PE=3 SV=1
UniRef50_Q6BXZ669.66%3231e-156DEHA2A13662p n=33 Tax=Eukaryota TaxID=2759 RepID=Q6BXZ6_DEBHA
Q6C8U8_YARLI69.57%3222e-158YALI0D16863p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16863g PE=3 SV=1
A0A060TGD1_BLAAD68.63%3221e-156ARAD1D22660p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22660g PE=3 SV=1
A0A1E4TLZ5_9ASCO68.54%3212e-153Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92635 PE=3 SV=1
A0A1D8PUA2_CANAL66.36%3241e-151Casein kinase 2 catalytic subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CKA1 PE=3 SV=1
A0A161HHJ2_9ASCO68.32%3222e-150Casein kinase 2 catalytic subunit CKA2 OS=Sugiyamaella lignohabitans GN=CKA2 PE=3 SV=1
A0A1E3PNU0_9ASCO63.35%3222e-149Casein kinase II OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81701 PE=3 SV=1
CSK22_YEAST61.13%3197e-129Casein kinase II subunit alpha' OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CKA2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1879

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 325

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd14132 (STKc_CK2_a...)

Residue annotation

  1. tetramer interface...
  2. CK2 beta interface...
  3. allosteric inhibit...
  4. active site cd14132
  5. ATP binding site c...
  6. polypeptide substr...
  7. activation loop (A...

Protein sequence

>MCA_00483_1
MTSVARVYADVNQKKPRSYWDYEQFSIPWGTQDHYEIVRRVGRGKYSEVFESIDISTNKYIVIKVLKPVKNKKIKREISI
LFNLANGTNIITLLDVVHDKGSKTTSLVFESIQNTDFRTLYPTFTNYDIKYYMYELLKALDYAHSMGIMHRDVKPHNVMI
DHAKRKLRLIDWGLAEYYHPRTAYNVRVASRYFKGPELLVEFQHYDYSLDLWSYGAMLASLIFKKEPFFHGNSNTDQLVK
IARVLGTEDLYEYVNKYNITLSREFEDLGTYERKPWSKYITDVNMKFATPEALDFIDHLLVYDHQNRLTAKEAMAHPYFD
EVRTN

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.