MCA_00475_1

Protein

Length

600 amino acids

RNA-seq: read pairs 7, FPKM 0.1, percentile rank 4.1% (100% = highest expression)

Protein function

EGGNOG:	0PFST	FG03636.1	MFS transporter (Seo1)
SGD closest match:	S000000062	SEO1	Probable transporter SEO1
CGD closest match:	CAL0000175721	CAALFM_CR06790CA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_00277_1	62.77%	599	0.0	MIA_00277_1
UniRef50_F2QQK0	55.24%	592	0.0	Biotin symporter n=11 Tax=Saccharomycetales TaxID=4892 RepID=F2QQK0_KOMPC
A0A0J9XDB5_GEOCN	57.14%	574	0.0	Similar to Saccharomyces cerevisiae YAL067C SEO1 Putative permease OS=Geotrichum candidum GN=BN980_GECA09s00252g PE=4 SV=1
A0A060SWU6_BLAAD	57.37%	502	0.0	ARAD1A08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08228g PE=4 SV=1
A0A1E3PMS6_9ASCO	53.43%	496	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46126 PE=4 SV=1
Q6C1T2_YARLI	48.99%	543	0.0	YALI0F13607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13607g PE=4 SV=1
SEO1_YEAST	50.00%	510	0.0	Probable transporter SEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEO1 PE=1 SV=1
Q59MT5_CANAL	48.86%	528	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06790CA PE=4 SV=1
A0A161HL86_9ASCO	28.80%	493	2e-62	Putative permease SEO1 OS=Sugiyamaella lignohabitans GN=SEO1 PE=4 SV=1
A0A1E4TIK6_9ASCO	24.29%	457	3e-28	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_72590 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0916

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
111 - 546
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 600 600

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  133 - 496
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  111 - 546
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  126 - 539
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 119

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

544 - 600

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

417 - 427

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

309 - 362

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

188 - 193

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

245 - 255

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

477 - 487

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

350 - 555

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

116 - 320

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

139 - 169

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

213 - 223

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

449 - 453

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

277 - 287

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

388 - 398

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

511 - 521

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

165 - 187

TMHMM
TMhelix (TMhelix)

488 - 510

TMHMM
TMhelix (TMhelix)

194 - 216

TMHMM
TMhelix (TMhelix)

365 - 387

TMHMM
TMhelix (TMhelix)

454 - 476

TMHMM
TMhelix (TMhelix)

402 - 421

TMHMM
TMhelix (TMhelix)

220 - 242

TMHMM
TMhelix (TMhelix)

291 - 313

TMHMM
TMhelix (TMhelix)

428 - 450

TMHMM
TMhelix (TMhelix)

254 - 276

TMHMM
TMhelix (TMhelix)

521 - 543

TMHMM
TMhelix (TMhelix)

120 - 138

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

428 - 448

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

454 - 476

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

120 - 138

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

363 - 387

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

522 - 543

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

399 - 416

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

170 - 187

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

288 - 308

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

256 - 276

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

224 - 244

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

488 - 510

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

194 - 212

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

560 - 600

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

143Q

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

146V

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

147N

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

148N

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

150Y

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

151V

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

169Q

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

172Y

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

173T

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

176S

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

180Q

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

181L

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

183M

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

184M

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

230E

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

231S

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

234Y

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

235P

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

238H

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

239Y

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

242G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

254G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

255S

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

258Y

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

259F

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

265L

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

375N

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

378N

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

379G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

382G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

383A

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

399I

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

403S

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

407P

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

410G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

414I

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

462Q

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

465G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

466W

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

469S

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

473F

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

474A

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

477A

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

490T

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

491V

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

494M

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

495N

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

498G

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

499Q

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

502T

putative substrate translocation pore
143Q, 146V, 147N, 148N, 150Y, 151V, 169Q, 172Y, 173T, 176S, 180Q, 181L, 183M, 184M, 230E, 231S, 234Y, 235P, 238H, 239Y, 242G, 254G, 255S, 258Y, 259F, 265L, 375N, 378N, 379G, 382G, 383A, 399I, 403S, 407P, 410G, 414I, 462Q, 465G, 466W, 469S, 473F, 474A, 477A, 490T, 491V, 494M, 495N, 498G, 499Q, 502T
CDD
cd06174 (MFS)

Protein sequence

>MCA_00475_1
MATYIKDRYHKVETRLQPLATKLRPYFPHLREIDEEEQHRILLERVAAREKREAKENHDLGIIAPVVLKEPEWEIRDEAN
RKWWALFNEYEYKQTTALQAKKRKWWAWFEETDTPEEKRLIIKLDILLCFFSFVMYWVKYLDQSNVNNAYVSGMKEELGM
KGNDLVNTQVVYTVGSVVFQLPMMYLVHRMPCNLLVPLMDFGWGLFTLAIYRANSVGELQAYRFFVGVFESAFYPTIHYL
LGSWYKPSEYARRGSIYYFGQMLGLLTAGLLQSAAYQHLNMTLGISGWRWMFILDTVCSLPIAIYGIWSIPGVPQKCYSI
FLTDQDIYVARKRMRDANISVETEGVNFFSLSLWKTVFSEWRFHLFAVLCILLWNNSNGSSGAYLLWLKSLNEYSIPLIN
QYSTITPALGFVWIYATGYLSDTARSRWGAILFSQLLNTLGNTLLAIWDLPKGVIWFAFCLQFFGWAASSITFAWAADAT
RHNPQIRAITVVGMNMLGQASTAVTSVLVWKTVEAPRFLKGYTFTAAIAFSMILWATFILPFYKRDERAHAHENGILLYN
SAKGESPPEPPSSHTDEYPDLKNKSSPVEVSQYEVSDNKF

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features