Protein

MCA_00441_1

Length
692 amino acids

Gene name: PAB1C

Description: Polyadenylate-binding protein, cytoplasmic and nuclear

Browser: contigA:1387781-1389860-

RNA-seq: read pairs 2869, FPKM 51.2, percentile rank 65.9% (100% = highest expression)

Protein function

Annotation:PAB1CPolyadenylate-binding protein, cytoplasmic and nuclear
KEGG:K13126PABPC polyadenylate-binding protein
EGGNOG:0PFWKPAB1Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity)
SGD closest match:S000000967PAB1Polyadenylate-binding protein, cytoplasmic and nuclear
CGD closest match:CAL0000195952PAB1Polyadenylate-binding protein, cytoplasmic and nuclear

Protein alignments

%idAln lengthE-value
MIA_00661_172.35%6690.0MIA_00661_1
A0A0J9XBX2_GEOCN68.96%5960.0Polyadenylate-binding protein OS=Geotrichum candidum GN=BN980_GECA08s03145g PE=3 SV=1
A0A167EIC1_9ASCO63.15%6160.0Polyadenylate-binding protein OS=Sugiyamaella lignohabitans GN=PAB1 PE=3 SV=1
A0A060T6K9_BLAAD63.31%6050.0Polyadenylate-binding protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B16500g PE=3 SV=1
PABP_YARLI59.50%6000.0Polyadenylate-binding protein, cytoplasmic and nuclear OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAB1 PE=3 SV=1
A0A1E3PFY9_9ASCO58.22%5960.0Polyadenylate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47563 PE=3 SV=1
UniRef50_P3120954.88%6050.0Polyadenylate-binding protein, cytoplasmic and nuclear n=140 Tax=Eukaryota TaxID=2759 RepID=PABP_SCHPO
A0A1E4T9Q8_9ASCO56.05%6030.0Polyadenylate-binding protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_70868 PE=3 SV=1
PABP_CANAL56.38%5960.0Polyadenylate-binding protein, cytoplasmic and nuclear OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAB1 PE=3 SV=1
PABP_YEAST60.73%4660.0Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAB1 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1809

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 692

Detailed signature matches

  1. Family IPR006515
    Polyadenylate binding protein, human types 1, 2, 3, 4
    1. TIGR01628
  2. Domain IPR000504
    RNA recognition motif domain
    1. SSF54928 (RNA-bindi...)
    2. PS50102 (RRM)
    3. SM00360 (rrm1_1)
    4. PF00076 (RRM_1)
  3. Domain IPR003954
    RNA recognition motif domain, eukaryote
    1. SM00361 (rrm2_1)
  4. Domain IPR002004
    Polyadenylate-binding protein/Hyperplastic disc protein
    1. PF00658 (PABP)
    2. SM00517 (poly_2)
    3. SSF63570 (PABC (PAB...)
    4. PS51309 (PABC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.19...
  3. G3DSA:3.30.70...
  4. cd12378 (RRM1_I_PABPs)
  5. cd12379 (RRM2_I_PABPs)
  6. cd12380 (RRM3_I_PABPs)
  7. cd12381 (RRM4_I_PABPs)
  8. mobidb-lite (disord...)

Residue annotation

  1. RNA binding site c...
  2. oligomer interface...
  3. RNA binding site c...

Protein sequence

>MCA_00441_1
MSTESFSATEKALENLSIKETPASESSPAATAPATTSSTPATTSESTEGAASTAAPATSSTEATTSEDAAAPATPSTGNV
SLYVGELDPSITEAMLFEIFNQIGPVASIRVCRDVITKRSLGYAYINYHNSADGARALNELNYTPIKGRPCRIMWSQRDP
SLRRTGTGNIFIKNLDPAIDNKDLFETFSTFGKILSAKIATDDYGNSKGYGFVHFESTEAAESAIENVNGMLLNDRKVFV
SRHIPKQDRQSKSEELKANYTNVYVKDIKPEVTEEEFKELFAKYGKITSAALARDQDGNSRGFGFVNFETHDAAASAVSE
LNGSEFHGNKIYVGRAQTKFEREEELKNQYEAARLEKSNMYQGVNLYIKNLDDSIDDDKLIELFSRFGTITSAKVMINES
GKSKGFGFVCFSAPEEATKAVAEMNQHMVANKPLYVALAQRKDVRRNQLAQQMQSKSQLRLQQQAAVAGGIPGQFIPPMY
YAGQQPAFMGPVPAGRPGVPFGGNPQVMMPPRQQVMATPPQGGWPPRGVGAGNQGMMPYMPGGFNNGYAGGNRGPRPVNY
PQGGRNGGRGGMRGGPAPMMPKGGESMLAASLANAPEENRKQIIGEYIFPKVVAHEQIGNAELASKITGMLLDMNLDELV
SIADNAPALDQNISAALRAYNEYIQTTPREDGANAASTPAGPEGSIPAEPLK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Cellular Component

None predicted.