Protein
MCA_00428_1
Length
1,915 amino acids
Gene name: ESP1
Description: Separin; separase, a caspase-like cysteine protease; promotes sister chromatid separation
Browser: contigA:1348202-1354060+
RNA-seq: read pairs 801, FPKM 5.2, percentile rank 17.7% (100% = highest expression)
Protein function
| Annotation: | ESP1 | Separin; separase, a caspase-like cysteine protease; promotes sister chromatid separation | |
|---|---|---|---|
| KEGG: | K02365 | ESP1 | separase [EC:3.4.22.49] |
| EGGNOG: | 0PHZC | SEPARIN | K02365 separase EC 3.4.22.49 |
| SGD closest match: | S000003330 | ESP1 | Separin |
| CGD closest match: | CAL0000192671 | ESP1 | Separase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00400_1 | 42.61% | 1915 | 0.0 | MIA_00400_1 |
| A0A0J9XJN5_GEOCN | 45.55% | 1460 | 0.0 | Similar to Saccharomyces cerevisiae YGR098C ESP1 Separase, a caspase-like cysteine protease OS=Geotrichum candidum GN=BN980_GECA19s01924g PE=4 SV=1 |
| UniRef50_A0A0J9XJN5 | 45.55% | 1460 | 0.0 | Similar to Saccharomyces cerevisiae YGR098C ESP1 Separase, a caspase-like cysteine protease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJN5_GEOCN |
| A0A167C907_9ASCO | 30.54% | 1470 | 0.0 | Esp1p OS=Sugiyamaella lignohabitans GN=ESP1 PE=4 SV=1 |
| A0A060T006_BLAAD | 31.86% | 1400 | 0.0 | ARAD1C08888p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C08888g PE=4 SV=1 |
| A0A1E3PS02_9ASCO | 26.96% | 2040 | 6e-180 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_39597 PE=4 SV=1 |
| Q6CCJ0_YARLI | 35.63% | 682 | 7e-117 | YALI0C08960p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C08960g PE=4 SV=1 |
| ESP1_YEAST | 35.77% | 548 | 4e-89 | Separin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESP1 PE=1 SV=2 |
| A0A1E4TM90_9ASCO | 30.81% | 529 | 6e-73 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_93747 PE=4 SV=1 |
| A0A1D8PCM0_CANAL | 34.20% | 269 | 7e-41 | Separase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ESP1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0684
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1200
1400
1600
1800
1915
Detailed signature matches
no IPR
Unintegrated signatures
-
-
PF03568 (Peptidase_C50)
-
mobidb-lite (disord...)
Protein sequence
>MCA_00428_1 MNKFTSCEIQSLSKQQMDMIKKTLDPSLEKAKPTKRITRTTRSRQTTSTHSTETPVQDPSEKIKLALNLLNQSLVFLNSL KPLSANTMSVASVKDACELASISASILYEEENKQNKDIYDCKKKHLSFILDLIDLNCLDETFRELQKLISIIYQRFHPDR TDAFQTSSSSKLNTIQKGTRKTKLHQVFVPLGTLLTIKPPQHIDEATANFVVFAQLALLKGLSKVPPKTLRPVSNEEILK SINHETGLRFWLSTLSPEIALGKTSLIAKVIIALSQGLSPVESFEFRLSALEMLPNLETIYIKSLLFSYTQIMKTSPKDK NGLELILSKFGTKLLHLINNKQEDFLKVNEFVTFIERLYSTAKEQNDEEQQEWFMLFSAYLSKSDKLLAYINNLQQTPLV EYSAIESIFSSENEELLSQYMTSQLFHRILLSLAAHVLKYSQIPHFNAIVRFYLTEKFKNNDSTKSHMKVAISKLSSLFS SALKNPDIVKTSSSKLLLVCDNIIDCLVLEEDYTQMLYLSHTLLATGSTLRSQKNPIHLDYWRKSFSIELNLQDKDVDHS SIVSIIKRLAVALVEHGNLEEAYEAISNSLGVLSKLDSIESKVDKCPPHLIWIRTADPSDNFYDLIFGVASKILLDCSDK IQPEFSNLSQFIEASALEQLLIHFKKSSRESCEKVAVKVMERLEKLLEEAPLRLLRVYNQFSRSIGSSYESFKPEMAHRL LHSIIDTKNLGVDTSLRAHQYFILAEAMLSFSVFSDAPTTEQYRYLNNSVNFTVEMFKKDVVSDTNDNISGHIHCLSSFL DLQGAHEKRAELLKAVIEHGGPGSRINLDSEFIICNRLDMVKSLITLGYTGTAIREIESITIDDKSIARKIDLAMYYLRK VECYVSIGETKKASKDFEILVDIINKDNILKSSLLKGRLQTEDRSHFRRRTILFAEICTVLAKLYTEEGNTELAISQSQK AVHFLQGFLKKFQKPNSGIPRETIWQLISTLISCQTQTAMGFEKLGIIRETCYFMEEGCKVAETSQCSLRLAAILAFDAE VRVKMGDLEKSAVSLKKCHELIKGLNLHDLNVMYYAHSAILSLQRQKLFSQENEYYTLSDQVFTDLKQKSHVFSITEIAE KISRLSISKEKEKEAANKLNSTVARGSAKTRVRTTRRQVISAKPSRPVATQKSVPTKPVQVPSRLPETQQPSEIFGIEVV WNSIVRSQVYSLGLQNSVENAISLLDGQYHSAGLRDQVLLDVFQAWNLYLLAKRELYSDAVFSFLSDSAISIPSTLRINN LTKDINYPQKAIENLEKSLELILKNTQNTMKACNATEINWISSLLNTIYLYLAAIKPSDELIRNNLQPYPNLLYQELSRS LTLKSDRKVFKLKSSDYNWPTNDASLNNITEKLDSLEIETIEESFRNENFSRILPEKWAAVTVNVCSETGSLGLTRYEKN KAPFQLNLPLNRHTSRDANEGSYTFEYGLQQLKDIIQKSNFSASKERTAMIKTQQDRQEWWTERYDLDKQLCQLMSDVEY FWLGGFTGIFSKKVPVPHLLDHLTAQINTLLQTYLPSRRWLRNGNVQREKNRNKTKSRNQEEHDEESRIQVDIHSKITEL FVGLGHPEGISDPGMLEDLIYYLFDILQFHGERNAYDEIDIDEFTVKIEAALTAYHTQAEEYYASNGANEIEHFVLILDK KSLGFCWESLPCLRNQSVSRAPSLSILADLLKTYYDPSVDPLWPIISAPPDNNNCHYILNPDKDLPKTQERFQSKFENLV GWSGKIGTEPTEKETAQMLEKGDIFVYMGHGSGQQYIRSAKIKSLKRCCCTVLLGCSSGVLTEAGDYDPWGTPVTYMSAG CPMLVANMWDVTDRDIDIFGTKMLEQWGVLMPEGGPLNELYSISEAVMRSRDECKLKYLNGSAPVIYGIPIKIRK
GO term prediction
Biological Process
GO:0006508 proteolysis
Molecular Function
GO:0005515 protein binding
GO:0008233 peptidase activity
Cellular Component
None predicted.