Protein

MCA_00400_1

Length
1,333 amino acids

Gene name: NTE1

Description: Lysophospholipase NTE1

Browser: contigA:1258371-1262442+

RNA-seq: read pairs 2135, FPKM 19.8, percentile rank 41.1% (100% = highest expression)

Protein function

Annotation:NTE1Lysophospholipase NTE1
KEGG:K14676NTE lysophospholipid hydrolase [EC:3.1.1.5]
EGGNOG:0PFPDNTE1Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity)
SGD closest match:S000004524NTE1Lysophospholipase NTE1
CGD closest match:CAL0000194621NTE1Lysophospholipase NTE1

Protein alignments

%idAln lengthE-value
MIA_01458_168.84%13350.0MIA_01458_1
A0A0J9XC16_GEOCN61.54%13000.0Lysophospholipase NTE1 OS=Geotrichum candidum GN=BN980_GECA08s03860g PE=3 SV=1
A0A060SYP2_BLAAD56.14%13270.0Lysophospholipase NTE1 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02662g PE=3 SV=1
UniRef50_A0A060SYP256.14%13270.0Lysophospholipase NTE1 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A060SYP2_BLAAD
NTE1_YARLI50.98%13320.0Lysophospholipase NTE1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NTE1 PE=3 SV=1
A0A167DL88_9ASCO56.56%10980.0Lysophospholipase NTE1 OS=Sugiyamaella lignohabitans GN=NTE1 PE=3 SV=1
A0A1E4TIB0_9ASCO46.57%13120.0Lysophospholipase NTE1 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32062 PE=3 SV=1
NTE1_CANAL43.48%13410.0Lysophospholipase NTE1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NTE1 PE=3 SV=1
NTE1_YEAST51.38%8680.0Lysophospholipase NTE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTE1 PE=1 SV=1
A0A1E3PLI8_9ASCO64.26%5400.0Patatin-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45806 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0190

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1333

Detailed signature matches

  1. Domain IPR014710
    RmlC-like jelly roll fold
    1. G3DSA:2.60.12...
  2. Domain IPR018490
    Cyclic nucleotide-binding-like
    1. SSF51206 (cAMP-bind...)
  3. Domain IPR000595
    Cyclic nucleotide-binding domain
    1. PF00027 (cNMP_binding)
    2. PS50042 (CNMP_BINDI...)
    3. SM00100 (cnmp_10)
  4. Domain IPR016035
    Acyl transferase/acyl hydrolase/lysophospholipase
    1. SSF52151 (FabD/lyso...)
  5. Domain IPR002641
    Patatin-like phospholipase domain
    1. PS51635 (PNPLA)
    2. PF01734 (Patatin)
  6. SITE IPR001423
    Lysophospholipase patatin, conserved site
    1. PS01237 (UPF0028)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:3.40.10...
  4. NON_CYTOPLASM... (N...)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. cd00038 (CAP_ED)
  8. mobidb-lite (disord...)

Residue annotation

  1. ligand binding sit...
  2. flexible hinge reg...
  3. ligand binding sit...
  4. flexible hinge reg...

Protein sequence

>MCA_00400_1
MEQAVVGVNDPLVGSIVVSEETPSSSIFWMISSLIVRTIGSISYLILSLLGKRFNITLKLSSLLLFLILLILVIWTIVRY
RYLTTYSRLPPEVPRQEPKLDLFMDTSPDQDSKGGFSTYLEDFFSAIKIFGYLDRSIFHELTRQMQTYKLEKGEIIKLDN
QKGFSVLVDGTIEVFAKTDDSDVRRRYDKDQMCLNGENYQLVNEVHKGAPVSSLFTILALFTGALTESRERSRPGSGNMS
SAESLDKFNLSEPQINSAEENSDANAGPNLNDFSDQSSNSTNANAKFRLQLNDIVARAAEDSTIAIIPQSTFHRLVLKYP
KATNHIIQVVLTRLSRVTFQSCHQYLGLTPEIFETEIELNNRASYKLPQYLRDRAVNGIREFIKKSPSSSNEPFIYLGKN
EKSFKHKLPNQSVVNGPRSRQVSLQPNSSHPGDLLSNVPLYRTETVNNYGTPGRPTTFNKLPFSADEETEDSALRFAITE
CIFKILRLDRPILKPDQPPSMIGSPVIGPVSEDSNRRSQRPSFSNVIKGLVPIEENYSFNDDDSVSSSVQSYDSAQVEAS
QNIEVMYYKKGSILMEQQGEAHGLFYVIDGLLEVEYHDKYGNNSSLYTVKPGGIAGFIASVLSSKSFVTVKAQTDVYVGF
LSQSVVERIAERYPMFLLGMANTLTGILPSLIVMLDFALDWVQVPGSHVLFNEGDDADAIYIVLNGRLRSVTKDANNNIK
IHGEYGQGESIGELEVLTVSKRPYTLHAIRETQLAKFPRSLFESLAKRHPSTTIEVSRIVASRVLNRLGAPSLQGYEIPP
SSNFRTVAVIPITAGLPVSEFGLKLQSAYNDISHNVFLLNISTVLRRLGRNAFNKIGILKLSGYLADLEERYQTVLYIAD
SSVTSPWTKTCMTQADCILLLADASTQPNMGEFERLLVTKKTTAKTELILLHRDRYVPDGLTAKWLKNRIWVNTHHHVQM
DFTTRVNEPEPLNSQEGGPLSKFRSKVKLIQSELITKYKQRGRPVYSNSYVHKNDFARLARILSGQAVGLVLGGGGARGI
SHIGVIRALEENGIPIDYVGGTSIGSFVGGLYAKEYDIVPIYGRAKKFASRISSLWRMAFDLTYPATSYTTGHEFNRGIW
KAFGETQIEDFWLRYFNNTTNITHSRMEIHESGYAWRYIRASMSLAGLLPPLTDKGSMLLDGGYVDNLPVEQMKSWGAKY
IFAVDVGSVDDTTPMTYGDSLSGLWVIFNRWNIFSRHPNVPNLAEIQQRLAYVSSVGALEKAKATSGVFYLRPPIDNYAT
LDFGKFDEIYRVGTIYGHQFLDNLKQENKFPKIPGAGVVKGRPRKQLTRRNSI

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0046470 phosphatidylcholine metabolic process

Molecular Function

GO:0004622 lysophospholipase activity

Cellular Component

None predicted.