MCA_00395_1

Protein

Length

330 amino acids

Gene name: SRT1

Description: Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)

Browser: contigA:1226959-1228252-

RNA-seq: read pairs 369, FPKM 13.8, percentile rank 32.1% (100% = highest expression)

Protein function

Annotation:		SRT1	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)
KEGG:	K11778	DHDDS	ditrans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.87]
EGGNOG:	0PFE2	SRT1	Putative undecaprenyl diphosphate synthase
SGD closest match:	S000000206	RER2	Dehydrodolichyl diphosphate synthase complex subunit RER2
CGD closest match:	CAL0000195761	SRT1	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)

Protein alignments

	%id	Aln length	E-value
MIA_01453_1	63.85%	343	7e-162	MIA_01453_1
A0A0J9X2I0_GEOCN	60.36%	275	2e-127	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Geotrichum candidum GN=BN980_GECA01s01913g PE=3 SV=1
UniRef50_A0A0J9X2I0	60.36%	275	4e-124	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2I0_GEOCN
Q6C8R7_YARLI	52.63%	285	3e-108	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D17556g PE=3 SV=1
A0A1E3PP48_9ASCO	53.14%	271	8e-107	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50540 PE=3 SV=1
A0A060T685_BLAAD	47.06%	272	6e-98	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09548g PE=3 SV=1
A0A161HIA6_9ASCO	48.61%	251	3e-90	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Sugiyamaella lignohabitans GN=RER2 PE=3 SV=1
A0A1D8PFD1_CANAL	46.15%	273	4e-85	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SRT1 PE=3 SV=1
A0A1E4TEJ9_9ASCO	38.37%	258	6e-68	Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56760 PE=3 SV=1
RER2_YEAST	42.52%	254	2e-65	Dehydrodolichyl diphosphate synthase complex subunit RER2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RER2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9368

Protein family membership

Decaprenyl diphosphate synthase-like (IPR001441)

Domains and repeats

None predicted.

Detailed signature matches

IPR001441

Decaprenyl diphosphate synthase-like
1. PF01255 (Prenyltransf)
  
  40 - 263
  
  Pfam
  PF01255 (Prenyltransf)
2. TIGR00055
  
  33 - 263
  
  TIGRFAMs
  TIGR00055 (TIGR00055)
3. SSF64005 (Undecapre...)
  
  30 - 258
  
  SUPERFAMILY
  SSF64005 (Undecaprenyl diphosphate synthase)
4. cd00475 (Cis_IPPS)
  
  36 - 257
  
  CDD
  cd00475 (Cis_IPPS)
5. MF_01139 (ISPT)
  
  33 - 265
  
  HAMAP
  MF_01139 (ISPT)
6. G3DSA:3.40.11...
  
  19 - 267
  
  GENE3D
  G3DSA:3.40.1180.10 (G3DSA:3.40.1180.10)
IPR018520

Di-trans-poly-cis-decaprenylcistransferase-like, conserved site
1. PS01066 (UPP_SYNTHASE)
  
  209 - 226
  
  PROSITE patterns
  PS01066 (UPP_SYNTHASE)

Residue annotation

active site cd00475

41M

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

42D

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

43G

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

44N

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

45R

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

46R

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

55L

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

59H

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

63F

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

66L

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

85A

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

93R

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

97E

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

104I

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

105I

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

108K

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

160I

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

213R

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

219R

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)

221S

active site
41M, 42D, 43G, 44N, 45R, 46R, 55L, 59H, 63F, 66L, 85A, 93R, 97E, 104I, 105I, 108K, 160I, 213R, 219R, 221S
CDD
cd00475 (Cis_IPPS)
dimer interface cd...

167R

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

168D

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

170M

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

171T

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

174I

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

175Q

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

191I

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

192D

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

193L

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

196F

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

207P

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

218T

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

219R

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

220F

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

221S

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

222D

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

225I

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

226W

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

227Q

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

229C

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

231D

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

232C

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

233T

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

234I

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

236F

dimer interface
167R, 168D, 170M, 171T, 174I, 175Q, 191I, 192D, 193L, 196F, 207P, 218T, 219R, 220F, 221S, 222D, 225I, 226W, 227Q, 229C, 231D, 232C, 233T, 234I, 236F
CDD
cd00475 (Cis_IPPS)

Protein sequence

>MCA_00395_1
MSLRSWFYNFPLSQFIHGFAQEFASSILNTGPVPQHIAFIMDGNRRFAKMNGLELGEGHVAGFESLSNLLEVCYGAGVNT
CTVYAFSIENFNRPQHEIDSLFNIIRNKLMIFAEKREIPERFGISIRFIGNRDLIPEDIMVLIERLEAATKNNTRGILNI
AFPYTSRDDMTQAIQKLADRVERGEIQAKDIDLNMFEEAMYTGDSPPMDIMVRTSGETRFSDFMIWQSCDDCTIEFIPVL
WPAFGPWDMFKILFKWSFKKTKFYQAEEIRQSKRFDVLKTLEGNNKIKVVETKSTPKLEQLPKVKGPIKVSVTEVAKNDA
IMAAAGTPVV

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_00395_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component