Protein
MCA_00337_1
Length
596 amino acids
Gene name: SLM3
Description: tRNA-specific 2-thiouridylase
Browser: contigA:1042415-1044206-
RNA-seq: read pairs 346, FPKM 7.2, percentile rank 20.8% (100% = highest expression)
Protein function
| Annotation: | SLM3 | tRNA-specific 2-thiouridylase | |
|---|---|---|---|
| KEGG: | K21027 | TRMU | tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14] |
| EGGNOG: | 0PHG8 | PGUG_04995 | tRNA-specific 2-thiouridylase |
| SGD closest match: | S000002191 | SLM3 | Mitochondrial tRNA-specific 2-thiouridylase 1 |
| CGD closest match: | CAL0000182034 | orf19.7245 | tRNA-5-taurinomethyluridine 2-sulfurtransferase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00033_1 | 45.64% | 574 | 8e-170 | MIA_00033_1 |
| A0A0J9X9L9_GEOCN | 46.50% | 471 | 5e-140 | Similar to Saccharomyces cerevisiae YDL033C SLM3 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs OS=Geotrichum candidum GN=BN980_GECA06s01308g PE=4 SV=1 |
| UniRef50_A0A0J9X9L9 | 46.50% | 471 | 1e-136 | Similar to Saccharomyces cerevisiae YDL033C SLM3 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9L9_GEOCN |
| A0A060T1T4_BLAAD | 44.59% | 462 | 1e-123 | ARAD1C18722p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C18722g PE=4 SV=1 |
| Q6C0F9_YARLI | 41.43% | 461 | 9e-117 | YALI0F25069p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25069g PE=4 SV=1 |
| A0A1D8PFW8_CANAL | 42.59% | 479 | 3e-113 | tRNA-5-taurinomethyluridine 2-sulfurtransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7245 PE=4 SV=1 |
| A0A161HIW6_9ASCO | 41.42% | 466 | 7e-107 | Slm3p OS=Sugiyamaella lignohabitans GN=SLM3 PE=4 SV=1 |
| MTU1_YEAST | 38.71% | 465 | 1e-99 | Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLM3 PE=1 SV=1 |
| A0A1E3PSC3_9ASCO | 49.68% | 314 | 5e-98 | 5-methylaminomethyl-2-thiouridylate-methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80985 PE=4 SV=1 |
| A0A1E4TAH0_9ASCO | 41.43% | 321 | 4e-76 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3368 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9642
Predicted cleavage: 41
Protein family membership
- tRNA-specific 2-thiouridylase (IPR004506)
Domains and repeats
-
Domain
1
100
200
300
400
500
596
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
Ligand Binding Sit...
Protein sequence
>MCA_00337_1 MYKRYCSISKAKPLFPFFERIVSKPIKSPIRLFAQCSYSTSVKINPEFDNNPQLDQINNYKKRVNEKKSEKVELNLSGAH IDYSDSEAPQIDLKVLEKINLDTIQDYKSTTYNTYPKNNNEIYADRMPGLEDDIWIGMSSGVDSSTAAALLVEKYGKDRV KGIFMANWDSIAAGGNSTKDGKQSNAVLQERCDEKDWQDVQTLCKNLGISCERVNFEQEYWQDVFEPMIEMYRIGQTPNP DVGCNKYIKFGSLIKHLEKKYINTDGDNGNSNINQRKWWLATGHYARVATHLPSNSVHLLRPDHLPKDQSYYLSTISSSV LQKIFFPLSHFPKPLIRQLAKYKYNLITADKPDSQGLCFVSQNQNKFRAFLDEYLEPSPGNIVRFRHNKEDGTREKVIVG QHNGIWHATVGQKSGVMMPQGNEETKGTWYVQSKNYDTNEIVIVKGNSNPSLFTQHITSKDFEWLVDPETLSWSNSSVST AVNNNKEIAATTGKVLLEWKASENDDDDDNNNDRGNFNESKFYVQYRSLQLPEPVKTLRVEKANVTSAESLPLHLVTVEL QTARRAVAPGQYLVIYRDNCIVGSGVISKTTPIVEP
GO term prediction
Biological Process
GO:0008033 tRNA processing
Molecular Function
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
Cellular Component
None predicted.