Protein

MCA_00309_1

Length
479 amino acids

Browser: contigA:941499-942939+

RNA-seq: read pairs 5659, FPKM 145.7, percentile rank 84.5% (100% = highest expression)

Protein function

KEGG:K00166BCKDHA 2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
EGGNOG:0PJTXFG09240.12-oxoisovalerate dehydrogenase
SGD closest match:S000000980PDA1Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
CGD closest match:CAL0000181135PDA1Pyruvate dehydrogenase E1 component subunit alpha

Protein alignments

%idAln lengthE-value
MIA_01651_174.77%4360.0MIA_01651_1
A0A0J9X4Z5_GEOCN66.83%4190.0Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA02s07358g PE=4 SV=1
A0A161HMV3_9ASCO62.83%4170.0Pyruvate dehydrogenase (Acetyl-transferring) subunit E1 alpha OS=Sugiyamaella lignohabitans GN=PDA1 PE=4 SV=1
A0A1E4TAP4_9ASCO56.06%4628e-175Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_128782 PE=4 SV=1
A0A060T960_BLAAD56.12%4173e-164ARAD1D09064p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D09064g PE=4 SV=1
Q6C9S7_YARLI54.92%4171e-161YALI0D08690p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08690g PE=4 SV=1
UniRef50_I1RY1251.55%4522e-154Uncharacterized protein n=42 Tax=saccharomyceta TaxID=716545 RepID=I1RY12_GIBZE
A0A1E3PJ57_9ASCO49.88%4211e-140Putative 2-oxoisovalerate dehydrogenase alpha subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_74860 PE=4 SV=1
ODPA_YEAST27.49%3421e-28Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDA1 PE=1 SV=2
Q5A0Z9_CANAL25.58%3441e-24Pyruvate dehydrogenase E1 component subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDA1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8754
Predicted cleavage: 23

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 479

Detailed signature matches

  1. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  2. Domain IPR001017
    Dehydrogenase, E1 component
    1. PF00676 (E1_dh)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02000 (TPP_E1_PDC...)

Residue annotation

  1. tetramer interface...
  2. TPP-binding site c...
  3. heterodimer interf...
  4. phosphorylation lo...

Protein sequence

>MCA_00309_1
MKSMQTLSSLSRKQTFALYSRAAATTQHLLRSKNFHTATTPLHQQSKQSILAGSHETPKGLDFPGISKSQFVDKINFLDP
RGLPPMEIYRLINVDGTQHDTAATIDVDKELAHRMYKEMHTISFLDNLMYEAQRQGRLSFYMVNAGEEASAIGSASAMQR
NDILFCQYREAGAILHRGLSLKHFMAQLYANKDDYAHGRSMPVHYMSKPLNIQPISSPLATQIPQAAGAAYALKVLGTKS
GKGAFKDPETQDHGACAICYFGDGAASEGDFHAALNMASTLGCPTIFFCRNNGYAISTPTSEQYKGDGIASRGYGYGMYT
IRVDGNDLLAVRRVTQQAREIATSQKRPVLIEAMSYRVSHHSTSDDSFAYRPKREVEDWKRRDNPMVRFRKWMENQGWWS
DADEQSLKKQVKTEVMKEFAAGEKTQKAKIKYLFEDIYDTLPPTLVEQRKELAEILDTYPDHFDLSSFEGGRAGLEEDK

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Component

None predicted.