Protein

MCA_00300_1

Length
818 amino acids

Gene name: IRC3

Description: Mitochondrial double-stranded DNA-dependent helicase of the DExH/D-box family

Browser: contigA:918759-921216+

RNA-seq: read pairs 740, FPKM 11.2, percentile rank 27.8% (100% = highest expression)

Protein function

Annotation:IRC3Mitochondrial double-stranded DNA-dependent helicase of the DExH/D-box family
KEGG:K17677IRC3 ATP-dependent helicase IRC3 [EC:3.6.4.-]
EGGNOG:0PGMYFG09790.1DEAD DEAH box helicase
SGD closest match:S000002740IRC3Putative ATP-dependent helicase IRC3
CGD closest match:CAL0000186343orf19.2798Double-stranded DNA-dependent ATPase

Protein alignments

%idAln lengthE-value
MIA_01342_138.63%7741e-159MIA_01342_1
A0A0J9XFM4_GEOCN38.26%7243e-142Similar to Saccharomyces cerevisiae YDR332W IRC3 Putative RNA helicase of the DEAH/D-box family OS=Geotrichum candidum GN=BN980_GECA14s02705g PE=4 SV=1
UniRef50_A0A0J9XFM438.26%7246e-139Similar to Saccharomyces cerevisiae YDR332W IRC3 Putative RNA helicase of the DEAH/D-box family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFM4_GEOCN
Q6C2M8_YARLI48.31%3852e-114YALI0F06534p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F06534g PE=4 SV=1
A0A167CNX5_9ASCO35.81%6453e-113Irc3p OS=Sugiyamaella lignohabitans GN=IRC3 PE=4 SV=1
IRC3_YEAST47.26%3833e-108Putative ATP-dependent helicase IRC3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRC3 PE=1 SV=1
Q59PU5_CANAL46.35%3841e-106Double-stranded DNA-dependent ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2798 PE=4 SV=1
A0A060T456_BLAAD34.87%6514e-103ARAD1C38984p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C38984g PE=4 SV=1
A0A1E4TAH9_9ASCO33.84%5974e-98Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16551 PE=4 SV=1
A0A1E3PRL8_9ASCO29.70%5323e-56Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81154 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9506
Predicted cleavage: 43

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 818

Detailed signature matches

  1. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  2. Domain IPR006935
    Helicase/UvrB, N-terminal
    1. PF04851 (ResIII)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00046 (DEXDc)
  4. cd00079 (HELICc)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_00300_1
MLLRRIYTQNVHRQLTNHYRYVLSFRNLTTRSPGLLFESKRFSSTATATAKVHNNQDISQNRNAVAELSKDHHNASHSKK
ISLREYQVDSIEACLKSFKEGKSRVAISMATGSGKTVVFSHLLSQVQPKPGQGNKVLVLAHRKELIIQAQATIQKFNPDL
KVEVEMAKFKSSPDADVIVASVPTIGNKRSNRLEQFDPKDFKLIIIDEAHHAAAGTYLRVLEHFDATSPDSSVYVAGFSA
TFERLDGLALTKAMDNIVYDNNVVKMIMEGHLSDFVVTTIKASYSLERFLEDDKKTKKDYDSATLDRLLNTEELNNFIYK
TYIKMGQQCNSTLVFCSSVNHVKALCAIFKENGIDAAYIYAGTSDIERAQIIEGFRSGKIRVLFNCGILTEGTDIPNIDC
IFLLRPTKSKALLMQMIGRGLRLHPGKKNCQILDFVGVTSAHKSRMATVPSLFGMDPDLVMEKAKMREEITKLEAENLEL
EEKKKSKSSRENDRLARLIRNCKLEEIQLETYKGIVQFLTDPSEDDDSKGQIEDSRLPIKQSKNNWLMLEPRHYILSSMN
SYLSLDYVTEADIEASLSSSSSSSSKNKKKATKLTPGWMLESHHKIERPYRGRSQSETSMFTMWSSHERFSGIQSAISAL
NAADTYAKGFFSNPHIIKKQAKWRKEEPTEGQLSELKRQCEKVLKMERIKNLVKKLDDCKSLASQLRSESETTLSLSPSA
LDLQKTADTNEESNQDLHRTTTTIDHLDWVMEMNKGEVSDLLSKTARSSKVLTNKFKEYYQKMINFKKQEIDVYKRQQKN
ELKELKMAEKKKKNGNSL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Cellular Component

None predicted.