Protein

MCA_00259_1

Length
395 amino acids

Gene name: PAN5

Description: 2-dehydropantoate 2-reductase

Browser: contigA:799975-801225+

RNA-seq: read pairs 1363, FPKM 42.5, percentile rank 61.8% (100% = highest expression)

Protein function

Annotation:PAN52-dehydropantoate 2-reductase
KEGG:K00077panE 2-dehydropantoate 2-reductase [EC:1.1.1.169]
EGGNOG:0PGQGPAN5Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
SGD closest match:S000001105PAN52-dehydropantoate 2-reductase
CGD closest match:CAL0000174456orf19.40062-dehydropantoate 2-reductase

Protein alignments

%idAln lengthE-value
MIA_05143_147.33%4126e-116MIA_05143_1
A0A0J9XIN9_GEOCN41.18%4253e-88Similar to Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase OS=Geotrichum candidum GN=BN980_GECA17s00615g PE=4 SV=1
UniRef50_A0A0J9XIN941.18%4257e-85Similar to Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIN9_GEOCN
A0A1D8PP61_CANAL31.01%3872e-422-dehydropantoate 2-reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4006 PE=4 SV=1
A0A060T6E4_BLAAD37.23%2319e-38ARAD1B11396p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B11396g PE=4 SV=1
Q6C0X8_YARLI27.68%4014e-38YALI0F20900p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20900g PE=4 SV=1
A0A1E3PNI2_9ASCO31.27%4031e-362-dehydropantoate 2-reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45225 PE=4 SV=1
A0A1E4TH77_9ASCO29.52%3932e-33Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148169 PE=4 SV=1
A0A167CG35_9ASCO38.69%1992e-282-dehydropantoate 2-reductase PAN5 OS=Sugiyamaella lignohabitans GN=PAN5 PE=4 SV=1
PANE_YEAST27.83%4061e-262-dehydropantoate 2-reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1118

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 395

Detailed signature matches

  1. Family IPR003710
    Ketopantoate reductase ApbA/PanE
    1. TIGR00745
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR013332
    Ketopantoate reductase, N-terminal domain
    1. PF02558 (ApbA)
  4. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
  5. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  6. Domain IPR013752
    Ketopantoate reductase, C-terminal domain
    1. PF08546 (ApbA_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)

Protein sequence

>MCA_00259_1
MGVPKIHVLGAGNIGALVATALASIPGKDVQPAVSLILRSREKVLDYNRQGGKLTIDRVSNGMPLEYSRNIPAIDPISLK
SSSSSTLDNLVVSVKVQQTIPAIQSLLPVITPKTTILLLQNGMGTYERLCDTFWPDINTRPQFFLGITTHGVNKITSKSK
RPPDAHAPEIQEFNYLNTFRYTHASNGVIKVAKVPQKPMEEQISIKDDVNSPSFDQQNAEEALASPLIDCLIKAPGLQTE
VLSYTAFIIAQTDKLLANAVINPLTAIFECYNGELTALSSIDLFIDQIINEFSMVFKKELEGKIPTPIISTIVDKTRLKA
IALDVIEKTSGNRSSMLQDVQALSDTEIDYINGYIWALATKNQVPITFNKLLVEMVKSKVSLGRDREKRSLPLIN

GO term prediction

Biological Process

GO:0015940 pantothenate biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008677 2-dehydropantoate 2-reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Cellular Component

GO:0005737 cytoplasm