Protein
MCA_00223_1
Length
547 amino acids
Gene name: LAP3
Description: Cysteine proteinase 1
Browser: contigA:694245-695889-
RNA-seq: read pairs 6041, FPKM 136.2, percentile rank 83.6% (100% = highest expression)
Protein function
| Annotation: | LAP3 | Cysteine proteinase 1 | |
|---|---|---|---|
| KEGG: | K01372 | BLMH | bleomycin hydrolase [EC:3.4.22.40] |
| EGGNOG: | 0PGMG | PGUG_01006 | bleomycin hydrolase |
| SGD closest match: | S000005183 | LAP3 | Cysteine proteinase 1, mitochondrial |
| CGD closest match: | CAL0000187653 | LAP3 | Bleomycin hydrolase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01281_1 | 71.64% | 476 | 0.0 | MIA_01281_1 |
| A0A0J9X6B9_GEOCN | 63.54% | 469 | 0.0 | Similar to Saccharomyces cerevisiae YNL239W LAP3 Cysteine aminopeptidase with homocysteine-thiolactonase activity OS=Geotrichum candidum GN=BN980_GECA03s07083g PE=4 SV=1 |
| UniRef50_A0A0J9XHA1 | 60.90% | 468 | 0.0 | Similar to Saccharomyces cerevisiae YNL239W LAP3 Cysteine aminopeptidase with homocysteine-thiolactonase activity n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHA1_GEOCN |
| A0A060TIF4_BLAAD | 52.14% | 468 | 1e-175 | ARAD1D46112p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D46112g PE=4 SV=1 |
| BLH1_YEAST | 46.17% | 470 | 7e-150 | Cysteine proteinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAP3 PE=1 SV=3 |
| A0A167FWM4_9ASCO | 43.47% | 467 | 3e-131 | Lap3p OS=Sugiyamaella lignohabitans GN=LAP3 PE=4 SV=1 |
| Q5A6L5_CANAL | 42.13% | 470 | 8e-129 | Bleomycin hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAP3 PE=4 SV=1 |
| A0A1E4TGU8_9ASCO | 41.60% | 500 | 3e-127 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_115187 PE=4 SV=1 |
| Q6C1A4_YARLI | 42.17% | 479 | 6e-122 | YALI0F17974p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F17974g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9151
Predicted cleavage: 26
Protein family membership
- Peptidase C1B, bleomycin hydrolase (IPR004134)
Domains and repeats
None predicted.
Detailed signature matches
-
-
PS00139 (THIOL_PROT...)
-
no IPR
Unintegrated signatures
-
-
SSF54001 (Cysteine ...)
-
mobidb-lite (disord...)
Residue annotation
-
trimer interface c...
-
active site cd00585
-
G bulge cd00585
Protein sequence
>MCA_00223_1 MLAISRRLSRLPSTLRGFGEQTVERNLKNASLISHFRSANVKLSHFPNSGTSFSSPHHTRSFHQSTTTMPGSPTLSNLTL DIEKLSSWSKENSSDLSSALASTVISNHGAATALISREAIQNKKLINVFSNVVTPEGSPIMNQKQSGRCWLFAGTNQMRI GIMRKYNLSELELSPSYLFFYDKLEKANFFLNQIEETAYKFVEAKDEAEKKEYDVESRLIQHLLTDPVVDGGQYDMFANI IAKYGLVPNHIYPDSFNTLASRNMNYMITTLLRQYAQEIRELVISKNGSEGLVDELKKLREDQIKHIYKLLCTFLGTPPG PNDPIVWEYVDKDKKYGSVETTPLGFYKDVVEYDVQSTISLLNDPRNEYNRLIKVDRLGNVVGRPYVTYVNVDIDVVSKT AVEMIKANTPVFFGTHTPIYHDRKSGLIDTDLWDYKLIGFDPKQNKADRLRYHQSLMTHAMLFTGVHLDPKTGEPVRWKV ENSWGSDPGIKGYFIMSHDFFKEYVYQIVVQKQDVKDEKLQKLIENWDNEEAIVLPPWDPCGALAKI
GO term prediction
Biological Process
GO:0006508 proteolysis
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Cellular Component
None predicted.