Protein

MCA_00218_1

Length
343 amino acids

Gene name: URA6A

Description: Uridylate kinase

Browser: contigA:683111-684143-

RNA-seq: read pairs 3751, FPKM 134.7, percentile rank 83.5% (100% = highest expression)

Protein function

Annotation:URA6AUridylate kinase
KEGG:K13800CMPK1 UMP-CMP kinase [EC:2.7.4.- 2.7.4.14]
EGGNOG:0PG3GPGUG_03601Uridylate kinase
SGD closest match:S000001507URA6Uridylate kinase
CGD closest match:CAL0000189392URA6Uridylate kinase

Protein alignments

%idAln lengthE-value
MIA_01286_178.03%2643e-157MIA_01286_1
A0A0J9X8A0_GEOCN69.08%2627e-133Uridylate kinase OS=Geotrichum candidum GN=URA6 PE=3 SV=1
A0A060T679_BLAAD59.62%2603e-108Uridylate kinase OS=Blastobotrys adeninivorans GN=URA6 PE=3 SV=1
A0A1E3PGZ3_9ASCO57.89%2664e-107Uridylate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=URA6 PE=3 SV=1
A0A167CX39_9ASCO58.17%2635e-102Uridylate kinase OS=Sugiyamaella lignohabitans GN=URA6 PE=3 SV=1
UniRef50_A0A167CX3958.17%2631e-98Uridylate kinase n=32 Tax=Fungi TaxID=4751 RepID=A0A167CX39_9ASCO
Q6C2B0_YARLI64.19%2154e-95Uridylate kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=URA6 PE=3 SV=1
Q59KZ3_CANAL61.64%2191e-89Uridylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA6 PE=3 SV=1
KCY_YEAST61.35%2071e-89Uridylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA6 PE=1 SV=1
A0A1E4TD72_9ASCO61.88%2024e-85Uridylate kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=URA6 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9969
Predicted cleavage: 58

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 343

Detailed signature matches

  1. Family IPR000850
    Adenylate kinase/UMP-CMP kinase
    1. PR00094 (ADENYLTKNASE)
    2. MF_00235 (Adenylate...)
    3. cd01428 (ADK)
  2. Family IPR006266
    UMP-CMP kinase
    1. MF_03172 (Adenylate...)
    2. TIGR01359
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. SITE IPR033690
    Adenylate kinase, conserved site
    1. PS00113 (ADENYLATE_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. PF00406 (ADK)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. mobidb-lite (disord...)

Residue annotation

  1. AMP-binding site c...
  2. ATP-AMP (Ap5A)-bin...

Protein sequence

>MCA_00218_1
MFKTLRFSSRTLARASSVCVKQTTVIRPLITSSFVKRVPTISTFQSARYFSNSSVVKSEPPSSPSSKSTPPPPPPPPRKD
DAPKFRYIVLVSILGTILFVYAERSVRKKKPRDFTSDDYEAIKARAKLRHKKSAFTPDEALVIFVLGGPGSGKGTQCANL
VKNFDFVHLSAGDLLREEQAREGSEYGELISNYIKEGKIVPQEVTLGLLKNAMKAEIMKRLDEDPHYLKKNGPVRFLIDG
FPRKMDQALSFEDNVCVSRFTLYFECPEEVMLKRLLKRGETSGRSDDNVESIKKRFRTFIETSMPVINYFDTSGKVLKIS
CDQPVDDVYNQVKIILQEKLGLY

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process

Molecular Function

GO:0004127 cytidylate kinase activity
GO:0005524 ATP binding
GO:0009041 uridylate kinase activity
GO:0019205 nucleobase-containing compound kinase activity

Cellular Component

None predicted.