MCA_00212_1
Gene name: HEM1
Description: 5-aminolevulinate synthase, mitochondrial
Browser: contigA:668093-669755-
RNA-seq: read pairs 3049, FPKM 68.0, percentile rank 71.9% (100% = highest expression)
Protein function
Annotation: | HEM1 | 5-aminolevulinate synthase, mitochondrial | |
---|---|---|---|
KEGG: | K00643 | E2.3.1.37 | 5-aminolevulinate synthase [EC:2.3.1.37] |
EGGNOG: | 0PHKA | HEM1 | 5-aminolevulinate synthase |
SGD closest match: | S000002640 | HEM1 | 5-aminolevulinate synthase, mitochondrial |
CGD closest match: | CAL0000189686 | HEM1 | 5-aminolevulinate synthase, mitochondrial |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_01291_1 | 76.06% | 564 | 0.0 | MIA_01291_1 |
A0A0J9XHV1_GEOCN | 68.74% | 563 | 0.0 | 5-aminolevulinate synthase OS=Geotrichum candidum GN=BN980_GECA19s00626g PE=3 SV=1 |
A0A060TF42_BLAAD | 63.51% | 559 | 0.0 | 5-aminolevulinate synthase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20020g PE=3 SV=1 |
HEM1_YARLI | 63.25% | 566 | 0.0 | 5-aminolevulinate synthase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HEM1 PE=3 SV=1 |
UniRef50_Q6CCW0 | 63.25% | 566 | 0.0 | 5-aminolevulinate synthase, mitochondrial n=37 Tax=Fungi TaxID=4751 RepID=HEM1_YARLI |
A0A167DL55_9ASCO | 60.48% | 582 | 0.0 | 5-aminolevulinate synthase OS=Sugiyamaella lignohabitans GN=HEM1 PE=3 SV=1 |
HEM1_CANAL | 58.81% | 556 | 0.0 | 5-aminolevulinate synthase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM1 PE=3 SV=2 |
A0A1E3PS32_9ASCO | 57.97% | 571 | 0.0 | 5-aminolevulinate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81251 PE=3 SV=1 |
A0A1E4TMF0_9ASCO | 57.17% | 558 | 0.0 | 5-aminolevulinate synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_95462 PE=3 SV=1 |
HEM1_YEAST | 63.27% | 452 | 0.0 | 5-aminolevulinate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9241
Predicted cleavage: 34
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
Detailed signature matches
-
cd06454 (KBL_like)
Residue annotation
-
substrate-cofactor...
-
pyridoxal 5'-phosp...
-
catalytic residue ...
Protein sequence
>MCA_00212_1 MDTLARQSKTLCPYIHRTSTETLRRLSAQAAITSVAKRCPIMSHAIQIREHHIDASKQVKKSHYSTIREVDLSKADPLFV AVPNPVKKPAKASATFEGDSNTPFNYEKTYENELARKHQDKSYRYFNNINRLANKFPKAHRGSEEEEVTVWCSNDYLGMG SNPVVVKAMHETIDKYGAGAGGTRNIAGHNKHALQLEHSLATLHKKDSALVFTSCFVANDATLALLGKKLPNAVYFSDEM NHASMIEGIRHSGAEKVIWKHNDLKDLEEKLARYPLGQPKIIAFESVYSMSGNISPIEAICDLADKYGALTFLDEVHAVG MYGPHGAGVAEHLDFEYHNSTGALAPERNGRDIMSRVDIITGTLGKAFGCMGGYVAGSKHFVDWVRSYAPGFIFTTSLPP AVMSGATAAIEYQKSSLKERVAQQQNTKYVKQELAKLGIPVVPNPSHIVPVLVGNAEKAKQASDMLLEKYSIYVQAINYP TVPIGQERLRITPTPGHNKELSDYLVKALDETFTTLKLDRVEDWAAQGGRCGVAEPGYEHAATPIWTEAQMKQ
GO term prediction
Biological Process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Molecular Function
GO:0003824 catalytic activity
GO:0003870 5-aminolevulinate synthase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Cellular Component
None predicted.