Protein

MCA_00147_1

Length
901 amino acids

Gene name: HRD3

Description: ERAD-associated E3 ubiquitin-protein ligase component HRD3

Browser: contigA:390691-393539-

RNA-seq: read pairs 1987, FPKM 27.2, percentile rank 49.9% (100% = highest expression)

Protein function

Annotation:HRD3ERAD-associated E3 ubiquitin-protein ligase component HRD3
KEGG:K14026SEL1 SEL1 protein
EGGNOG:0PFCTHRD3ubiquitin-protein ligase Sel1 Ubx2
SGD closest match:S000004197HRD3ERAD-associated E3 ubiquitin-protein ligase component HRD3
CGD closest match:CAL0000187118orf19.1191Ubiquitin ligase complex subunit

Protein alignments

%idAln lengthE-value
MIA_00498_156.88%6610.0MIA_00498_1
A0A0J9XCR8_GEOCN38.76%7745e-158Similar to Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) OS=Geotrichum candidum GN=BN980_GECA09s03508g PE=4 SV=1
UniRef50_A0A0J9XCR838.76%7741e-154Similar to Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCR8_GEOCN
A0A167D442_9ASCO38.18%6811e-120Ubiquitin ligase complex subunit HRD3 OS=Sugiyamaella lignohabitans GN=HRD3 PE=4 SV=1
A0A060TAF7_BLAAD34.12%6804e-91ARAD1B06666p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B06666g PE=4 SV=1
Q6C383_YARLI32.77%5891e-86YALI0F01859p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F01859g PE=4 SV=1
A0A1E3PCW6_9ASCO31.83%6001e-77HCP-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48282 PE=4 SV=1
A0A1E4TL36_9ASCO30.10%6081e-66Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86889 PE=4 SV=1
A0A1D8PPB6_CANAL27.70%6103e-49Ubiquitin ligase complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1191 PE=4 SV=1
HRD3_YEAST23.93%6311e-28ERAD-associated E3 ubiquitin-protein ligase component HRD3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRD3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2174

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Repeat
1 100 200 300 400 500 600 700 800 901

Detailed signature matches

  1. Domain IPR011990
    Tetratricopeptide-like helical domain
    1. G3DSA:1.25.40.10
  2. Repeat IPR006597
    Sel1-like repeat
    1. SM00671 (sel1)
    2. PF08238 (Sel1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:2.60.40...
  4. NON_CYTOPLASM... (N...)
  5. SIGNAL_PEPTIDE (Sig...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SSF81901 (HCP-like)
  10. SignalP-TM
  11. TMhelix
  12. TRANSMEMBRANE (Tran...)
  13. mobidb-lite (disord...)

Protein sequence

>MCA_00147_1
MHIYRRKCIKLLLLATVAFTFLISSQLVTAYDSQNYGGQQQQVLQAPVGNNDDNKSFSPEEIERDKRKGKFLYMEARSIL
NSLPDVTNPDNIGRFYRPPYYILKTIKSFEPREIGHFVVGLFSESLRDKIFGKDVEKSHSYYSNKQLLSSQTKKKLKILE
EKKLELKRAFELLAESCKYGNLDALYTKAELYFYGNYTHPQDFDQSFQHYRRVADISGNATAQFMLGVMHSTGMFGTVPQ
DQALAHLYYHFAAQGGDNRAKMAMGFRLMHGIATPSNFTLAARYYKEVADKAYENFMDGPPGGRHLKQYSWLLSDAQGGL
YGKGASRSPPSKRYPLLPASSSQTFGMAFRYLKYLALLEDSVAPANYALANLFYDGDIVIDPNYEMAAKYAKECLKETTG
NPKFKSIHGLCSGFLGLRYLRGEGVDQNFNIAMRLFKQGIKYDDFVSMNGLGLMYLEGLGVEKNEMEAAALFKRAGSYGP
AHYNLARIYLRRGDLPNAFLQLDIASKRNNIPALYHQGMLLYNGSVGKMSESTPYFQLVSERVHDLHSSLRWAHKRYDEG
DYGSAILGFLLAAEEGYQEAQLNLAYMLDDENQYFSFKKFFPHLFGFKVEMKDSNTQEKLSAPENEHTFSGSYLNHDQQD
YSPSDLTNYTTWKQQKDFLAFIYWTRSAKQYNIDALVKVGDYFLKGIGVRPNPTEAASRYQVAADYASSLARWNLGWMYE
NGIGVDQDFHLAKRYYDYAASNDMDAYFPVQLSLLKLRLRSSWNALWKSPSDHKHNTLSEEESAQEKSIIVDADNPLDGK
NDRPSSFREGLKLFWKKWKERGGLNPELNDERENDNVNVNNLDNPDEDVNALNEDEEIEELSDFESLLFFIVVGIIGMVM
FYRFIQQGYNEVRRAINNRNR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.