MCA_00090_1

Protein

Length

464 amino acids

Gene name: APM1

Description: Mu1-like medium subunit of the AP-1 complex, clathrin adaptor protein

Browser: contigA:238636-240031+

RNA-seq: read pairs 6154, FPKM 163.5, percentile rank 85.8% (100% = highest expression)

Protein function

Annotation:		APM1	Mu1-like medium subunit of the AP-1 complex, clathrin adaptor protein
KEGG:	K12393	AP1M	AP-1 complex subunit mu
EGGNOG:	0PGQF	FG08982.1	complex, subunit
SGD closest match:	S000006180	APM1	AP-1 complex subunit mu-1-I
CGD closest match:	CAL0000186413	APM1	Apm1p

Protein alignments

	%id	Aln length	E-value
MIA_04149_1	82.62%	466	0.0	MIA_04149_1
A0A167BXE1_9ASCO	73.16%	462	0.0	Apm1p OS=Sugiyamaella lignohabitans GN=APM1 PE=3 SV=1
A0A060T0E8_BLAAD	71.86%	462	0.0	ARAD1C12518p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C12518g PE=3 SV=1
A0A0J9X2R5_GEOCN	72.61%	471	0.0	Similar to Saccharomyces cerevisiae YPL259C APM1 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1) OS=Geotrichum candidum GN=BN980_GECA01s09393g PE=3 SV=1
Q6CEZ3_YARLI	65.89%	472	0.0	YALI0B11682p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B11682g PE=3 SV=1
A0A1E3PIE8_9ASCO	66.95%	466	0.0	Clathrin adaptor, mu subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46920 PE=3 SV=1
UniRef50_A0A0F0IQC0	67.25%	455	0.0	Adaptor complexes medium subunit family protein n=8 Tax=leotiomyceta TaxID=716546 RepID=A0A0F0IQC0_ASPPU
A0A1E4TG63_9ASCO	64.36%	463	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_110094 PE=3 SV=1
AP1M1_YEAST	53.07%	488	2e-180	AP-1 complex subunit mu-1-I OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APM1 PE=1 SV=2
Q5AJY4_CANAL	56.38%	470	4e-177	Apm1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APM1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3393

Protein family membership

Clathrin adaptor, mu subunit (IPR001392)

Domains and repeats

Domain
1 - 140
Longin-like domain (IPR011012)
AP complex, mu/sigma subunit (IPR022775)
156 - 461
Mu homology domain (IPR028565)

1 50 100 150 200 250 300 350 400 464

Detailed signature matches

IPR001392

Clathrin adaptor, mu subunit
1. PIRSF005992 (AP_com...)
  
  1 - 461
  
  PIRSF
  PIRSF005992 (AP_complex_mu)
2. PR00314 (CLATHRINADPT)
  
  315 - 330
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  355 - 366
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  12 - 32
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  158 - 186
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  100 - 127
  
  PRINTS
  PR00314 (CLATHRINADPT)
  
  246 - 273
  
  PRINTS
  PR00314 (CLATHRINADPT)
IPR011012

Longin-like domain
1. SSF64356 (SNARE-like)
  
  1 - 140
  
  SUPERFAMILY
  SSF64356 (SNARE-like)
IPR022775

AP complex, mu/sigma subunit
1. PF01217 (Clat_adapt...)
  
  3 - 131
  
  Pfam
  PF01217 (Clat_adaptor_s)
IPR028565

Mu homology domain
1. SSF49447 (Second do...)
  
  156 - 460
  
  SUPERFAMILY
  SSF49447 (Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor)
2. PF00928 (Adap_comp_sub)
  
  156 - 461
  
  Pfam
  PF00928 (Adap_comp_sub)
3. PS51072 (MHD)
  
  167 - 460
  
  PROSITE profiles
  PS51072 (MHD)
IPR018240

Clathrin adaptor, mu subunit, conserved site
1. PS00991 (CLAT_ADAPT...)
  
  266 - 280
  
  PROSITE patterns
  PS00991 (CLAT_ADAPTOR_M_2)
2. PS00990 (CLAT_ADAPT...)
  
  156 - 176
  
  PROSITE patterns
  PS00990 (CLAT_ADAPTOR_M_1)

no IPR

Unintegrated signatures

G3DSA:2.60.40...

149 - 324

GENE3D
G3DSA:2.60.40.1170 (G3DSA:2.60.40.1170)

400 - 455

GENE3D
G3DSA:2.60.40.1170 (G3DSA:2.60.40.1170)
G3DSA:3.30.45...

1 - 142

GENE3D
G3DSA:3.30.450.60 (G3DSA:3.30.450.60)
cd09250 (AP-1_Mu1_C...)

153 - 458

CDD
cd09250 (AP-1_Mu1_Cterm)

Residue annotation

heterotetramer int...

165Y

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

185T

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

187K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

189L

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

190S

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

200K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

210R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

247E

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

250K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

274E

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

281R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

283N

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

297R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

309R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

311R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

317R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

322D

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

341S

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

346K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

349P

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

350E

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

359K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

365K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

366E

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

368V

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

416K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

417F

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

418T

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

421F

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

430R

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

431Y

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

432L

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

433K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

443S

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

444Y

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

445P

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

446W

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

447V

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

452K

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

454G

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)

455N

heterotetramer interface
165Y, 185T, 187K, 189L, 190S, 200K, 210R, 247E, 250K, 274E, 281R, 283N, 297R, 309R, 311R, 317R, 322D, 341S, 346K, 349P, 350E, 359K, 365K, 366E, 368V, 416K, 417F, 418T, 421F, 430R, 431Y, 432L, 433K, 443S, 444Y, 445P, 446W, 447V, 452K, 454G, 455N
CDD
cd09250 (AP-1_Mu1_Cterm)
signal peptide bin...

171F

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

172L

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

173D

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

200K

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

321N

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

418T

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

420P

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

445P

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

446W

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

447V

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

448R

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

450V

signal peptide binding site
171F, 172L, 173D, 200K, 321N, 418T, 420P, 445P, 446W, 447V, 448R, 450V
CDD
cd09250 (AP-1_Mu1_Cterm)

Protein sequence

>MCA_00090_1
MASAIFFLDMKGKPLLSRNYRGDIPMSAIEKFPLLLLEAEEETSVVPPCISKDGINYLYITHNDLFVLALTRRNSNAAEI
LLFLHRIVKVLTEYFKRLTEESIRDNFVIIYELLDEMMDFGYPQTTETQILQEYITQESHALDVQVKPPVAVTNAVSWRS
EGIYYKKNEAFLDVIESVNMMVSPTGKVLSSEILGSIQMKCFLSGMPELRLGLNDRVIFDRQSNTTGQIMPTTRGGAGPG
KGPIELEDIKFHQCVRLSRFESDRTISFIPPDGEFELMSYRLNTSVKPLIWVDCRFRNFSNTRIEIQARARAQFKSRSHA
NDIDIVIPVPDDADSPRFKTSSGSVKWKPEISAVVWHMKKLVGGKEAVMTAELNLPSVRGDDDAAVTSGEVGLVGAVSNS
STGANFGSYKKPISVKFTIPFFTTSGIQVRYLKIIEPKLQYPSYPWVRYVTKSGNDYTIRIAKY

GO term prediction

Biological Process

GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

None predicted.

Cellular Component

GO:0030131 clathrin adaptor complex

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Status

Per-residue features