Protein

MCA_00072_1

Length
564 amino acids

Gene name: PUT2

Description: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Browser: contigA:182056-183751-

RNA-seq: read pairs 1468, FPKM 32.1, percentile rank 54.6% (100% = highest expression)

Protein function

Annotation:PUT2Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
KEGG:K00294E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88]
EGGNOG:0PG3TPUT2Delta-1-pyrroline-5-carboxylate dehydrogenase
SGD closest match:S000001079PUT2Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
CGD closest match:CAL0000194832PUT21-pyrroline-5-carboxylate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_04129_179.41%5730.0MIA_04129_1
A0A1E3PE92_9ASCO70.11%5520.0Delta-1-pyrroline-5-carboxylate dehydrogenase 1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48039 PE=3 SV=1
A0A0J9XD55_GEOCN70.86%5490.0Similar to Saccharomyces cerevisiae YHR037W PUT2 Delta-1-pyrroline-5-carboxylate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA08s04443g PE=3 SV=1
A0A167E4T6_9ASCO69.78%5560.01-pyrroline-5-carboxylate dehydrogenase OS=Sugiyamaella lignohabitans GN=PUT2 PE=3 SV=1
A0A060T6A1_BLAAD66.26%5690.0ARAD1B10098p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10098g PE=3 SV=1
Q6CF74_YARLI61.31%5660.0YALI0B09647p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09647g PE=4 SV=1
Q5AK46_CANAL61.40%5440.01-pyrroline-5-carboxylate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PUT2 PE=3 SV=1
A0A1E4TB31_9ASCO58.09%5560.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32308 PE=3 SV=1
UniRef50_Q9P8I057.89%5510.0Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial n=277 Tax=Eukaryota TaxID=2759 RepID=PUT2_EMENI
PUT2_YEAST55.23%5740.0Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUT2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9681
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 564

Detailed signature matches

  1. Family IPR005931
    Delta-1-pyrroline-5-carboxylate dehydrogenase
    1. TIGR01236
    2. cd07123 (ALDH_F4-17...)
  2. Domain IPR016161
    Aldehyde/histidinol dehydrogenase
    1. SSF53720 (ALDH-like)
  3. Domain IPR016162
    Aldehyde dehydrogenase N-terminal domain
    1. G3DSA:3.40.60...
  4. Domain IPR015590
    Aldehyde dehydrogenase domain
    1. PF00171 (Aldedh)
  5. SITE IPR029510
    Aldehyde dehydrogenase, glutamic acid active site
    1. PS00687 (ALDEHYDE_D...)
  6. SITE IPR016160
    Aldehyde dehydrogenase, cysteine active site
    1. PS00070 (ALDEHYDE_D...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.30...

Residue annotation

  1. Glutamate binding ...
  2. NAD binding site c...
  3. catalytic residues...

Protein sequence

>MCA_00072_1
MLRTTVKKQLRQYSTAIPQWATFKVPKITNEPIRSFEPGSKDRQGVIDALKKYTGTMDVPTVIGGKEIFNKETFQQKSPY
KHSHVVANVSSTTPDQVHEAIKSSMEAKRDWENAPWSDRAAVFLKAADLITGKYRYDMLATTMIGQGKNVFQAEIDTTCE
IADFLRFNTKYAEELYAQQPTETTPGSWNRAEYRPLEGFTYAVTPFNFTAIAGNLVGAPALMGNTVVWKPSDSAVLSNYL
LFKIFQEAGVPDGVINFVPGNPREITQQVISSPDFSALHYTGSTQVFLSLYQQIASNLENYKSYPRIVGETGGKNFHVIH
NSANVANAARSTVRGAFEYQGQKCSATSRAYVPKSIWPEFKEILIKETESLHNHQGNAASAEGFHYFSGPVIHEPSFNKL
ANAFKTAEADPKLTLLTGGTADKSVGYYVKPTVYETSDPNHPFLSTEFFGPLLTVYVYEDADFEKTLEIVDKTSKYGLTG
SIFAKDRDAISLASSVLRNAAGNFYINDKSTGAVVGQQWFGGARMSGTNDKAGSGNILTRFVSVRNIKETFVELEDIYYP
SNKQ

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0010133 proline catabolic process to glutamate
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.