Protein

MCA_00056_1

Length
160 amino acids

Gene name: GRX5

Description: Monothiol glutaredoxin-5, mitochondrial

Browser: contigA:140339-140945+

RNA-seq: read pairs 4782, FPKM 367.0, percentile rank 93.1% (100% = highest expression)

Protein function

Annotation:GRX5Monothiol glutaredoxin-5, mitochondrial
KEGG:K07390grxD monothiol glutaredoxin
EGGNOG:0PNPZGRX5Glutaredoxin
SGD closest match:S000005980GRX5Monothiol glutaredoxin-5, mitochondrial
CGD closest match:CAL0000183749orf19.2782Monothiol glutaredoxin

Protein alignments

%idAln lengthE-value
MIA_04101_175.17%1458e-74MIA_04101_1
A0A0J9X5Q6_GEOCN88.07%1097e-70Glutaredoxin OS=Geotrichum candidum GN=BN980_GECA03s02892g PE=3 SV=1
A0A060T5H7_BLAAD80.73%1093e-62Glutaredoxin OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05544g PE=3 SV=1
UniRef50_A0A093Y7V366.91%1364e-54Monothiol glutaredoxin-5, mitochondrial n=1 Tax=Talaromyces marneffei PM1 TaxID=1077442 RepID=A0A093Y7V3_TALMA
Q59PW1_CANAL73.39%1092e-54Monothiol glutaredoxin OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2782 PE=4 SV=1
Q6C0W3_YARLI74.51%1023e-54Glutaredoxin OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F21219g PE=3 SV=1
GLRX5_YEAST74.26%1013e-52Monothiol glutaredoxin-5, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GRX5 PE=1 SV=1
A0A1E3PDS9_9ASCO73.53%1023e-52Glutaredoxin (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6266 PE=4 SV=1
A0A170QY03_9ASCO82.28%793e-48Glutaredoxin OS=Sugiyamaella lignohabitans GN=GRX5 PE=3 SV=1
A0A1E4TH84_9ASCO47.19%891e-24Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2838 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9901
Predicted cleavage: 53

Protein family membership

Domains and repeats

  1. Domain
1 20 40 60 80 100 120 140 160 160

Detailed signature matches

  1. Family IPR004480
    Monothiol glutaredoxin-related
    1. TIGR00365
  2. Family IPR014434
    Monothiol glutaredoxin
    1. PIRSF005894 (Monoth...)
  3. Domain IPR012336
    Thioredoxin-like fold
    1. SSF52833 (Thioredox...)
  4. Domain IPR002109
    Glutaredoxin
    1. PF00462 (Glutaredoxin)
    2. PS51354 (GLUTAREDOX...)
  5. Domain IPR033658
    Glutaredoxin, PICOT-like
    1. cd03028 (GRX_PICOT_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.30.10
  2. SFLDG00327 (monothi...)

Residue annotation

  1. putative GSH bindi...
  2. SFLDG00327
  3. catalytic residues...

Protein sequence

>MCA_00056_1
MLSRNLMFASRNAARIGTKSSIASSRILPTSFISQRFNLGSVRFLSDETKAAIDKAVESAPVVLFMKGTPEQPMCGFSRN
TIQILGYQGVDPSKFAAYNVLDDPELRQGIKEYSSWPTIPQLYVNKEFIGGHDIVVAMNDSGELTELLEKEDVLVPEEEE

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis

Molecular Function

GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0015036 disulfide oxidoreductase activity

Cellular Component

None predicted.