Protein

MCA_00033_1

Length
307 amino acids

Description: 3-hydroxybutyryl-CoA dehydrogenase, mitochondrial

Browser: contigA:81392-82390+

RNA-seq: read pairs 1834, FPKM 73.6, percentile rank 73.6% (100% = highest expression)

Protein function

Annotation:3-hydroxybutyryl-CoA dehydrogenase, mitochondrial
KEGG:K00074paaH 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
EGGNOG:0PKJIFG06813.13-Hydroxybutyryl-CoA dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_04094_185.57%2983e-177MIA_04094_1
A0A0J9X3N2_GEOCN77.85%3073e-160Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s11142g PE=4 SV=1
Q6CCJ7_YARLI68.73%3079e-138YALI0C08811p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C08811g PE=4 SV=1
A0A167EM61_9ASCO67.91%2961e-135Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_5203 PE=4 SV=1
A0A1E4TCB2_9ASCO68.15%2926e-131Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32659 PE=4 SV=1
A0A1E3PL99_9ASCO66.23%3024e-129Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82110 PE=4 SV=1
UniRef50_B8MDV764.56%3166e-1203-hydroxybutyryl-CoA dehydrogenase, putative n=6 Tax=Dikarya TaxID=451864 RepID=B8MDV7_TALSN
A0A060T7G6_BLAAD65.03%2869e-1223-hydroxybutyryl-CoA dehydrogenase OS=Blastobotrys adeninivorans GN=ATPK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9838
Predicted cleavage: 23

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 307

Detailed signature matches

  1. Family IPR022694
    3-hydroxyacyl-CoA dehydrogenase
    1. PIRSF000105 (HCDH)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR006176
    3-hydroxyacyl-CoA dehydrogenase, NAD binding
    1. PF02737 (3HCDH_N)
  4. Domain IPR008927
    6-phosphogluconate dehydrogenase C-terminal domain-like
    1. SSF48179 (6-phospho...)
  5. Domain IPR013328
    6-phosphogluconate dehydrogenase, domain 2
    1. G3DSA:1.10.10...
  6. Domain IPR006108
    3-hydroxyacyl-CoA dehydrogenase, C-terminal
    1. PF00725 (3HCDH)
  7. SITE IPR006180
    3-hydroxyacyl-CoA dehydrogenase, conserved site
    1. PS00067 (3HCDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...

Protein sequence

>MCA_00033_1
MYRHISKSVMQKRLFSSSRLNKDVSNLTVIGGGQMGLGIALVAANKAGVKVNLVDTSDAALEKGMKFMDKLLAKDVKKGR
LTEEQAKEVTSRVNPTTDLISSVKSTDMVIEAVPEIPELKFKIFSQLAEHAPKDAILATNTSSISITRIAAAAKGAESRV
VAAHFMNPVPVQPGVEIIEALQTDKSITEDTLKFVGRMGKVPSVSKDSPGFIANRILMPYINEAIICLETGIGSAKDIDS
MMVNGCAMPMGPLALADFIGLDTCLAIMKVLYNDTGDSKYRPSVYLGKMVDAGWLGKKSGKGFYEYK

GO term prediction

Biological Process

GO:0006631 fatty acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0070403 NAD+ binding

Cellular Component

None predicted.