MIA_01046_1

Protein

Length

375 amino acids

Protein function

EGGNOG:	0PHZX	FG09312.1	3-methyl-2-oxobutanoate hydroxymethyltransferase
SGD closest match:	S000000380	ECM31	3-methyl-2-oxobutanoate hydroxymethyltransferase
CGD closest match:	CAL0000175867	orf19.6057	3-methyl-2-oxobutanoate hydroxymethyltransferase

Protein alignments

	%id	Aln length	E-value
MCA_02597_1	72.87%	328	3e-161	MCA_02597_1
A0A1E3PRL4_9ASCO	68.81%	295	3e-137	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81143 PE=3 SV=1
A0A0J9X3N5_GEOCN	64.84%	310	6e-135	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Geotrichum candidum GN=BN980_GECA02s01066g PE=3 SV=1
A0A167F564_9ASCO	63.88%	299	9e-131	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Sugiyamaella lignohabitans GN=ECM31 PE=3 SV=1
Q6CE35_YARLI	60.56%	322	9e-126	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B18898g PE=3 SV=1
A0A060T9E1_BLAAD	60.93%	302	6e-117	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17138g PE=3 SV=1
UniRef50_A0A1X2IAU0	50.31%	324	7e-104	Ketopantoate hydroxymethyltransferase-domain-containing protein n=2 Tax=Cunninghamellaceae TaxID=4851 RepID=A0A1X2IAU0_9FUNG
A0A1E4TC36_9ASCO	52.46%	284	4e-96	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138323 PE=3 SV=1
Q5ABB3_CANAL	50.00%	288	5e-96	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6057 PE=3 SV=1
PANB_YEAST	41.36%	295	2e-66	3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM31 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9981
Predicted cleavage: 52

Protein family membership

Ketopantoate hydroxymethyltransferase (IPR003700)

Domains and repeats

Domain
92 - 354
Pyruvate/Phosphoenolpyruvate kinase-like domain (IPR015813)

1 50 100 150 200 250 300 350 375

Detailed signature matches

IPR003700

Ketopantoate hydroxymethyltransferase
1. MF_00156 (PanB)
  
  93 - 354
  
  HAMAP
  MF_00156 (PanB)
2. cd06557 (KPHMT-like)
  
  95 - 348
  
  CDD
  cd06557 (KPHMT-like)
3. TIGR00222
  
  94 - 354
  
  TIGRFAMs
  TIGR00222 (TIGR00222)
4. PF02548 (Pantoate_t...)
  
  92 - 349
  
  Pfam
  PF02548 (Pantoate_transf)
IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain
1. SSF51621 (Phosphoen...)
  
  92 - 354
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)

no IPR

Unintegrated signatures

G3DSA:3.20.20.60

80 - 354

GENE3D
G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
mobidb-lite (disord...)

1 - 88

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

oligomerization in...

95V

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

96L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

115D

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

116Y

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

117I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

118S

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

121I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

136L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

138M

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

139V

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

140S

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

141L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

142G

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

143Y

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

147N

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

148E

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

153E

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

156Y

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

157H

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

160A

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

163R

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

176F

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

177G

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

187A

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

191I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

194I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

195K

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

200Q

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

218T

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

219T

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

220M

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

221G

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

222I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

223S

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

233Q

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

234R

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

236A

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

237S

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

238L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

239G

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

267F

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

307L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

310L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

311G

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

325S

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

328L

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

329D

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

330I

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

331N

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)

332T

oligomerization interface
95V, 96L, 115D, 116Y, 117I, 118S, 121I, 136L, 138M, 139V, 140S, 141L, 142G, 143Y, 147N, 148E, 153E, 156Y, 157H, 160A, 163R, 176F, 177G, 187A, 191I, 194I, 195K, 200Q, 218T, 219T, 220M, 221G, 222I, 223S, 233Q, 234R, 236A, 237S, 238L, 239G, 267F, 307L, 310L, 311G, 325S, 328L, 329D, 330I, 331N, 332T
CDD
cd06557 (KPHMT-like)
active site cd06557

112T

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

131L

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

133G

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

134D

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

135S

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

173D

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

203K

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

227H

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

232P

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

272E

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

303V

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)

305V

active site
112T, 131L, 133G, 134D, 135S, 173D, 203K, 227H, 232P, 272E, 303V, 305V
CDD
cd06557 (KPHMT-like)
metal binding site...

134D

metal binding site
134D, 173D, 203K
CDD
cd06557 (KPHMT-like)

173D

metal binding site
134D, 173D, 203K
CDD
cd06557 (KPHMT-like)

203K

metal binding site
134D, 173D, 203K
CDD
cd06557 (KPHMT-like)

Protein sequence

>MIA_01046_1
MQRSLARLAPKTTRPRTARRPAIVPTQISCSSSSRSQIHTFAAPPLRSSRPATCCSDSPRLTPSRAPRPESVRWSHYNST
PADGSAPTVRPRVTVLDIKKMHKNKVPISVITAHDYISALIADRAQVDVILVGDSLSMVSLGYENTNEIELDEMIYHAKA
VSRGSKSCLLVADLPFGSYEISSEQAAASAIQMIKRGDMQAIKIEGGVENSATIKKLTTMGISVMGHIGLTPQRQASLGG
FKVQGKTAESAESILQDALALQDAGCFAIVLEAVPAPMAQLITEKLSIPTIGIGAGPHTSGQVLVQLDMLGGFDGFTPKF
LKKYSNYLDINTKAIKQYNEEVKQRQFPEPQHCYNIKQENVDKFKQLLQEKYSHL

GO term prediction

Biological Process

GO:0015940 pantothenate biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features