MIA_mt_19350958

Protein

Length

249 amino acids

Browser: mtDNA:19334-21976+

Protein function

EGGNOG:	0PMT7	COX2	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (By similarity)
SGD closest match:	S000007281	COX2	Cytochrome c oxidase subunit 2
CGD closest match:	CAL0000186073	COX2	Cytochrome c oxidase subunit 2

Protein alignments

	%id	Aln length	E-value
MCA_mt_19351080	86.831%	243	1.54e-163	MCA_mt_19351080
A0A0A1I5X5_GEOCN	79.832%	238	1.09e-150	Cytochrome c oxidase subunit 2 OS=Geotrichum candidum GN=cox2 PE=3 SV=1
A0A060RCP3_BLAAD	75.000%	240	2.48e-140	Cytochrome c oxidase subunit 2 OS=Blastobotrys adeninivorans GN=cox2 PE=3 SV=1
COX2_YEAST	69.547%	243	1.06e-131	Cytochrome c oxidase subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COX2 PE=1 SV=1
UniRef50_P00410	69.547%	243	2.55e-128	Cytochrome c oxidase subunit 2 n=196 Tax=Opisthokonta TaxID=33154 RepID=COX2_YEAST
COX2_YARLI	63.071%	241	2.36e-122	Cytochrome c oxidase subunit 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COX2 PE=3 SV=1
COX2_CANAL	61.157%	242	8.07e-114	Cytochrome c oxidase subunit 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=COX2 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0699

Protein family membership

None predicted.

Domains and repeats

Domain
7 - 109
Cytochrome C oxidase subunit II, transmembrane domain (IPR011759)
Domain
25 - 246
Cytochrome c oxidase, subunit II (IPR014222)
Domain
106 - 249
Cupredoxin (IPR008972)
Cytochrome c oxidase subunit II-like C-terminal (IPR002429)
Cytochrome c oxidase subunit 2, C-terminal (IPR034210)

1 50 100 150 200 249

Detailed signature matches

IPR011759

Cytochrome C oxidase subunit II, transmembrane domain
1. PS50999 (COX2_TM)
  
  13 - 109
  
  PROSITE profiles
  PS50999 (COX2_TM)
2. PF02790 (COX2_TM)
  
  13 - 100
  
  Pfam
  PF02790 (COX2_TM)
3. SSF81464 (Cytochrom...)
  
  7 - 108
  
  SUPERFAMILY
  SSF81464 (Cytochrome c oxidase subunit II-like, transmembrane region)
IPR014222

Cytochrome c oxidase, subunit II
1. TIGR02866
  
  25 - 246
  
  TIGRFAMs
  TIGR02866 (TIGR02866)
IPR008972

Cupredoxin
1. G3DSA:2.60.40...
  
  106 - 249
  
  GENE3D
  G3DSA:2.60.40.420 (G3DSA:2.60.40.420)
2. SSF49503 (Cupredoxins)
  
  110 - 249
  
  SUPERFAMILY
  SSF49503 (Cupredoxins)
IPR002429

Cytochrome c oxidase subunit II-like C-terminal
1. PS50857 (COX2_CUA)
  
  110 - 248
  
  PROSITE profiles
  PS50857 (COX2_CUA)
2. PF00116 (COX2)
  
  113 - 237
  
  Pfam
  PF00116 (COX2)
IPR034210

Cytochrome c oxidase subunit 2, C-terminal
1. cd13912 (CcO_II_C)
  
  111 - 245
  
  CDD
  cd13912 (CcO_II_C)
IPR001505

Copper centre Cu(A)
1. PS00078 (COX2)
  
  182 - 230
  
  PROSITE patterns
  PS00078 (COX2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 37

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

105 - 249

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.10.28...

14 - 105

GENE3D
G3DSA:1.10.287.90 (G3DSA:1.10.287.90)
NON_CYTOPLASM... (N...)

62 - 80

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PR01166 (CYCOXIDASEII)

87 - 107

PRINTS
PR01166 (CYCOXIDASEII)

201 - 218

PRINTS
PR01166 (CYCOXIDASEII)

219 - 236

PRINTS
PR01166 (CYCOXIDASEII)

157 - 178

PRINTS
PR01166 (CYCOXIDASEII)

109 - 128

PRINTS
PR01166 (CYCOXIDASEII)

75 - 87

PRINTS
PR01166 (CYCOXIDASEII)

181 - 201

PRINTS
PR01166 (CYCOXIDASEII)
TMhelix

81 - 103

TMHMM
TMhelix (TMhelix)

38 - 60

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

81 - 104

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

38 - 61

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

subunit II/VIb int...

111P

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

112A

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

114T

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

116K

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

127E

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

174R

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

180N

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

201R

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

202L

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

203N

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)

204Q

subunit II/VIb interface
111P, 112A, 114T, 116K, 127E, 174R, 180N, 201R, 202L, 203N, 204Q
CDD
cd13912 (CcO_II_C)
subunit II/VIc int...

162D

subunit II/VIc interface
162D, 164R, 169I, 170D, 212E
CDD
cd13912 (CcO_II_C)

164R

subunit II/VIc interface
162D, 164R, 169I, 170D, 212E
CDD
cd13912 (CcO_II_C)

169I

subunit II/VIc interface
162D, 164R, 169I, 170D, 212E
CDD
cd13912 (CcO_II_C)

170D

subunit II/VIc interface
162D, 164R, 169I, 170D, 212E
CDD
cd13912 (CcO_II_C)

212E

subunit II/VIc interface
162D, 164R, 169I, 170D, 212E
CDD
cd13912 (CcO_II_C)
CuA binding site c...

184H

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)

219C

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)

221E

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)

223C

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)

227H

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)

230M

CuA binding site
184H, 219C, 221E, 223C, 227H, 230M
CDD
cd13912 (CcO_II_C)
subunit I/II inter...

194K

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

196D

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

199P

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

201R

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

203N

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

218Q

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

219C

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

220S

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

221E

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

225A

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

227H

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)

228A

subunit I/II interface
194K, 196D, 199P, 201R, 203N, 218Q, 219C, 220S, 221E, 225A, 227H, 228A
CDD
cd13912 (CcO_II_C)
subunit II/IV inte...

214V

subunit II/IV interface
214V, 216Y
CDD
cd13912 (CcO_II_C)

216Y

subunit II/IV interface
214V, 216Y
CDD
cd13912 (CcO_II_C)

Protein sequence

>MIA_mt_19350958
MFNLYFNMMFNDVPKAWGMYFQDSATAMAEGMMELHDIIMFYMVIVLTLVTYMLYSMMTSFNNNKNPMSYKYMIHGTTLE
VIWTMFPAVMLMFIALPSFVLLYLSDEVIDPAMTVKAIGYQWYWVYEYSDFINDSGETIQLESYIIPDDLLEEGQLHSLD
VDNRLVAPIDTHIRIVVTANDVIHDFTVPSLGIKIDACPGRLNQLSAIIQREGVFYGQCSELCGAAHAYMPIVIEAVTLP
KFLEWLNEQ

GO term prediction

Biological Process

GO:0022900 electron transport chain

Molecular Function

GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features