MIA_mt_19350928

Protein

Length

277 amino acids

Protein function

EGGNOG:	0PJUY	COX3	Subunits I, II and III form the functional core of the enzyme complex
SGD closest match:	S000007283	COX3	Cytochrome c oxidase subunit 3
CGD closest match:	CAL0000183335	COX3A	Cytochrome c oxidase subunit 3

Protein alignments

	%id	Aln length	E-value
A0A0A1I5X3_GEOCN	80.669%	269	5.92e-157	Cytochrome c oxidase subunit 3 OS=Geotrichum candidum GN=cox3 PE=3 SV=1
MCA_mt_19351036	71.377%	276	5.50e-144	MCA_mt_19351036
A0A060RCV0_BLAAD	58.741%	286	1.28e-112	Cytochrome c oxidase subunit 3 OS=Blastobotrys adeninivorans GN=cox3 PE=3 SV=1
COX3_YARLI	61.567%	268	2.21e-104	Cytochrome c oxidase subunit 3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=COX3 PE=3 SV=1
UniRef50_P00422	55.762%	269	1.80e-99	Cytochrome c oxidase subunit 3 n=182 Tax=Opisthokonta TaxID=33154 RepID=COX3_NEUCR
COX3_YEAST	58.209%	268	3.33e-102	Cytochrome c oxidase subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COX3 PE=3 SV=3
COX3_CANAL	55.762%	269	4.00e-102	Cytochrome c oxidase subunit 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=COX3A PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0150

Protein family membership

None predicted.

Domains and repeats

Domain
17 - 277
Cytochrome c oxidase-like subunit III (IPR000298)
Cytochrome c oxidase subunit III domain (IPR033945)
Domain
87 - 277
Cytochrome c oxidase, subunit III, 4-helical bundle (IPR013833)

1 50 100 150 200 250 277

Detailed signature matches

IPR000298

Cytochrome c oxidase-like subunit III
1. PS50253 (COX3)
  
  18 - 277
  
  PROSITE profiles
  PS50253 (COX3)
2. SSF81452 (Cytochrom...)
  
  17 - 276
  
  SUPERFAMILY
  SSF81452 (Cytochrome c oxidase subunit III-like)
3. PF00510 (COX3)
  
  20 - 277
  
  Pfam
  PF00510 (COX3)
IPR033945

Cytochrome c oxidase subunit III domain
1. cd01665 (Cyt_c_Oxid...)
  
  32 - 275
  
  CDD
  cd01665 (Cyt_c_Oxidase_III)
IPR013833

Cytochrome c oxidase, subunit III, 4-helical bundle
1. G3DSA:1.20.12...
  
  87 - 277
  
  GENE3D
  G3DSA:1.20.120.80 (G3DSA:1.20.120.80)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

193 - 211

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

75 - 94

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

277 - 277

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.10.28...

15 - 86

GENE3D
G3DSA:1.10.287.70 (G3DSA:1.10.287.70)
NON_CYTOPLASM... (N...)

237 - 255

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

118 - 172

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 56

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

146 - 168

TMHMM
TMhelix (TMhelix)

57 - 74

TMHMM
TMhelix (TMhelix)

212 - 234

TMHMM
TMhelix (TMhelix)

175 - 197

TMHMM
TMhelix (TMhelix)

20 - 42

TMHMM
TMhelix (TMhelix)

254 - 276

TMHMM
TMhelix (TMhelix)

95 - 117

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

256 - 276

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

57 - 74

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

173 - 192

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

212 - 236

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

95 - 117

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

Subunit III/VIIa i...

72L

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

75R

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

76D

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

79S

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

82T

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

83Y

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)

84L

Subunit III/VIIa interface
72L, 75R, 76D, 79S, 82T, 83Y, 84L
CDD
cd01665 (Cyt_c_Oxidase_III)
Phospholipid bindi...

73W

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

74F

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

77I

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

78I

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

81G

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

87H

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

98G

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

99F

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

102F

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

230M

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

237R

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

249L

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)

250G

Phospholipid binding site
73W, 74F, 77I, 78I, 81G, 87H, 98G, 99F, 102F, 230M, 237R, 249L, 250G
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit I/III inte...

90A

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

93N

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

94G

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

105S

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

108M

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

112G

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

113M

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

119H

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

207G

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

208V

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

211S

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)

215L

Subunit I/III interface
90A, 93N, 94G, 105S, 108M, 112G, 113M, 119H, 207G, 208V, 211S, 215L
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/VIb in...

135L

Subunit III/VIb interface
135L
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/VIa in...

143T

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

144E

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

145L

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

162Y

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

188M

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

198T

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

199T

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

200A

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

205S

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

206D

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)

207G

Subunit III/VIa interface
143T, 144E, 145L, 162Y, 188M, 198T, 199T, 200A, 205S, 206D, 207G
CDD
cd01665 (Cyt_c_Oxidase_III)
Subunit III/Vb int...

174H

Subunit III/Vb interface
174H
CDD
cd01665 (Cyt_c_Oxidase_III)

Protein sequence

>MIA_mt_19350928
MNNNKNVTMLNMHRQQYQLHPFHLVENSPWPILTSFSMFGLAMNTALTSHGYIGNSWWVMLSMINVTYMLFLWFRDIISE
GTYLGNHTLAVRNGMNLGFMLFMVSECMFFLGMFWAFGHSALNPTVELGGVWPPLGMEAIGPTELPLLNTMLLLSSGATL
TYSHHYLINGNRWHALFGLFITVLLAVMFMMCQYIEYTTASFTMSDGVFGSVFYLGTGFHGFHVLMGMIMLSISYWRMWN
YHSTNNHHLGFHTSVLYYHFVDVVWLILFMLVYWWGS

GO term prediction

Biological Process

GO:0022904 respiratory electron transport chain

Molecular Function

GO:0004129 cytochrome-c oxidase activity
GO:0015002 heme-copper terminal oxidase activity

Cellular Component

GO:0016020 membrane

Filter view on

Entry type

Status

Per-residue features