MIA_06401_1

Protein

Length

601 amino acids

Protein function

EGGNOG:	0PFF2	FG04799.1	transporter
SGD closest match:	S000001382	QDR1	Quinidine resistance protein 1
CGD closest match:	CAL0000179742	QDR2	MFS antiporter QDR2

Protein alignments

	%id	Aln length	E-value
A0A0J9X3J0_GEOCN	46.215%	502	7.47e-148	Similar to Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane multidrug transporter of the major facilitator superfamily OS=Geotrichum candidum GN=BN980_GECA01s03805g PE=4 SV=1
UniRef50_A0A0J9X494	45.996%	487	4.17e-140	Similar to Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane multidrug transporter of the major facilitator superfamily n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X494_GEOCN
MCA_01246_1	48.606%	502	7.80e-139	MCA_01246_1
A0A060TCH4_BLAAD	47.095%	482	4.10e-130	ARAD1D36146p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36146g PE=4 SV=1
A0A1E3PGV9_9ASCO	43.513%	501	5.63e-127	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83453 PE=4 SV=1
A0A167F432_9ASCO	41.828%	569	2.73e-125	Qdr2p OS=Sugiyamaella lignohabitans GN=QDR2 PE=4 SV=1
Q6C300_YARLI	39.020%	551	4.56e-108	YALI0F03751p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F03751g PE=4 SV=1
QDR2_CANAL	35.759%	481	1.09e-88	MFS antiporter QDR2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=QDR2 PE=3 SV=1
QDR1_YEAST	32.549%	510	2.40e-83	Quinidine resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=QDR1 PE=1 SV=1
A0A1E4TAB1_9ASCO	36.345%	487	7.64e-80	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3307 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0158
Predicted cleavage: 11

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
100 - 585
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 601

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  122 - 527
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  117 - 567
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  337 - 417
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  100 - 302
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
  
  446 - 585
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  121 - 558
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

292 - 355

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

419 - 449

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

502 - 512

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

229 - 239

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

176 - 181

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 113

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

562 - 601

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

571 - 591

COILS
Coil (Coil)
G3DSA:1.20.12...

340 - 579

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

103 - 305

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

377 - 395

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

472 - 476

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

533 - 537

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

202 - 206

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

136 - 154

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

261 - 271

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

538 - 560

TMHMM
TMhelix (TMhelix)

240 - 262

TMHMM
TMhelix (TMhelix)

356 - 378

TMHMM
TMhelix (TMhelix)

388 - 410

TMHMM
TMhelix (TMhelix)

206 - 228

TMHMM
TMhelix (TMhelix)

116 - 138

TMHMM
TMhelix (TMhelix)

272 - 291

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

153 - 175

TMHMM
TMhelix (TMhelix)

182 - 201

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

207 - 228

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

272 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

538 - 561

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

477 - 501

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

356 - 376

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

155 - 175

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

182 - 201

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

240 - 260

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

450 - 471

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

396 - 418

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

513 - 532

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

114 - 135

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 27

MobiDB Lite
mobidb-lite (disorder_prediction)

578 - 601

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

132V

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

135Y

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

136L

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

137S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

139L

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

140T

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

157V

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

160F

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

161T

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

164Q

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

168P

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

169A

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

171W

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

172G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

218I

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

219A

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

222V

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

223A

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

226S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

227G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

230G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

242I

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

243G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

246S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

247G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

253S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

367Y

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

370W

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

371F

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

374I

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

375T

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

378S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

392L

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

396Y

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

400G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

403S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

407S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

488S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

491S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

492M

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

495F

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

499S

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

500T

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

503V

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

514A

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

515A

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

517V

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

518N

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

521R

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

522G

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

525C

putative substrate translocation pore
132V, 135Y, 136L, 137S, 139L, 140T, 157V, 160F, 161T, 164Q, 168P, 169A, 171W, 172G, 218I, 219A, 222V, 223A, 226S, 227G, 230G, 242I, 243G, 246S, 247G, 253S, 367Y, 370W, 371F, 374I, 375T, 378S, 392L, 396Y, 400G, 403S, 407S, 488S, 491S, 492M, 495F, 499S, 500T, 503V, 514A, 515A, 517V, 518N, 521R, 522G, 525C
CDD
cd06174 (MFS)

Protein sequence

>MIA_06401_1
MSEIFINPRPSPQSSQISPHVTPTHSFNNSQQELELTNAQEDCGFTDVENLQRVQSLANQNLTRIISETGDFAAYQSLNQ
EIIQTLGEKNLNAEVIETTDSDQPQYTVFSSKEVVFIAIEASCAAFFSTISVPIYLSALTDLANEFQVSTERINLTVTVF
TIVQAIVPALWGAIADSIGRRPVILMCLFIYIGANIGLAFAKNYGFLIGFRILQAAGIASTVAVGSGIVGDITERKNRGF
YIGIYSGLSMVGSAIGPLIGGSLAATLGWRSIFWFLVIAAGVTLVFMLILLPETSRKIVGNGSVKPSSWINKTPYMSFRK
YFIRGARAETPSPQTVLPPSPIKLHRTLQLFLEKDVLIILLPNAIHYTSWFMLITAQSTLLTKYYHFTTLQLGLSYIANG
GGSVLGSLVGGKVMNLAYNYEVVRFRKAHGHEEEEISAQNPKFNIHRARLWPLPIVSSIHIAATLIFGWSIQYHVHFAVP
IVFTAFVSFASMFSFSLSSTLMVDLFPSESSSAAAAVNLSRGTICAVGISLVDRMDQAMGTGGTFSLMAGLMFLSWALNF
YEIKNGPRFHQERLQKQRDLEERQKEKMQIDGEKLGNDTCT

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features