Protein
MIA_06371_1
Length
538 amino acids
Browser: contig11:221083-222753-
Protein function
| EGGNOG: | 0PFZZ | FG07264.1 | thiamine biosynthetic bifunctional enzyme |
|---|---|---|---|
| SGD closest match: | S000006135 | THI6 | Thiamine biosynthetic bifunctional enzyme |
| CGD closest match: | CAL0000179143 | THI6 | Bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A1E3PP80_9ASCO | 46.715% | 548 | 3.94e-147 | Thiamine biosynthetic bifunctional enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81786 PE=3 SV=1 |
| UniRef50_A0A1E3PP80 | 46.715% | 548 | 1.07e-143 | Thiamine biosynthetic bifunctional enzyme n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PP80_9ASCO |
| A0A167D4I6_9ASCO | 42.652% | 558 | 2.98e-142 | Bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase OS=Sugiyamaella lignohabitans GN=THI6 PE=3 SV=1 |
| A0A0J9X5W5_GEOCN | 46.140% | 557 | 4.09e-140 | Similar to Saccharomyces cerevisiae YPL214C THI6 Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities OS=Geotrichum candidum GN=BN980_GECA03s03882g PE=3 SV=1 |
| A0A060T700_BLAAD | 46.402% | 528 | 7.89e-139 | ARAD1B18722p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B18722g PE=3 SV=1 |
| Q5AEJ1_CANAL | 40.935% | 535 | 2.04e-123 | Bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=THI6 PE=3 SV=1 |
| Q6CBT9_YARLI | 41.698% | 530 | 1.21e-114 | YALI0C15554p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C15554g PE=3 SV=1 |
| A0A1E4TCF9_9ASCO | 41.373% | 510 | 5.66e-110 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_40887 PE=3 SV=1 |
| THI6_YEAST | 36.166% | 553 | 5.77e-98 | Thiamine biosynthetic bifunctional enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI6 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0972
Protein family membership
- Thiamine phosphate synthase (IPR034291)
- Hydroxyethylthiazole kinase (IPR000417)
Domains and repeats
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Domain
1
50
100
150
200
250
300
350
400
450
500
538
Detailed signature matches
-
-
-
SSF53613 (Ribokinas...)
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no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
Residue annotation
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thiamine phosphate...
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active site cd00564
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pyrophosphate bind...
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substrate binding ...
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multimerization in...
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ATP binding site c...
Protein sequence
>MIA_06371_1 MTDARKKIDYTLYLVTDSTMLPPGADFFDHVEKTLANGAVTIVQLREKNIDTKDFVAKAKKLHEITKKYNVPLIINDRVD VALASDAEGVHVGQEDLDVPALRKLIGQDKIIGVSTHDPTEIKRAIEEGADYVGIGAVYGTKTKDLTRAPIGTVGLKEVL LAADNKIPAVAIGGINASNVQRVLYFSATPDKNVKVAGIAVVSAIMANSDPSEASRELRALISENPSWDLTAKIPWDEKF TKEKILTDISELLYRVKGLKPLVHHITNDVVKNLSANVTIAIGASPVMSECLDEFEDLASYSNSSCLINMGTPTLESVAL YRQAGGEYNKRGKTVIFDPVGAGATRLRTKACKELLQHVAFDVIKGNDAEIYAAAGFQSPTKQTGVDSDTDADNEARFQA AYKLAQDYRTIVLMTGPEDLLVDEHGNALIFSNGSEYLSLITGSGCSLGSLISAVVATDKSLLDQIEDRLPYGTFLATAA ALSLFTVASEQAANFPTCTGPGTFVPLFLDQLYAISKENRLGNTRWLSRINVRPFKQD
GO term prediction
Biological Process
GO:0009228 thiamine biosynthetic process
Molecular Function
GO:0003824 catalytic activity
GO:0004417 hydroxyethylthiazole kinase activity
GO:0004789 thiamine-phosphate diphosphorylase activity
Cellular Component
None predicted.