Protein

MIA_06355_1

Length
709 amino acids

Browser: contig11:175396-177526+

Protein function

EGGNOG:0PGDAFG05249.1prolyl-tRNA synthetase
SGD closest match:S000001062YHR020WPutative proline--tRNA ligase YHR020W
CGD closest match:CAL0000176548orf19.6701Proline--tRNA ligase

Protein alignments

%idAln lengthE-value
A0A0J9XH21_GEOCN75.246%7110.0Similar to Saccharomyces cerevisiae YHR020W Prolyl-tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA16s00296g PE=3 SV=1
MCA_05842_173.061%7090.0MCA_05842_1
A0A1E3PF17_9ASCO66.481%7190.0Proline-tRNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52795 PE=3 SV=1
A0A060TI14_BLAAD65.657%6930.0ARAD1D42724p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D42724g PE=3 SV=1
A0A167BXN0_9ASCO64.944%7160.0Proline--tRNA ligase OS=Sugiyamaella lignohabitans GN=AWJ20_3747 PE=3 SV=1
UniRef50_B9WKB461.376%7120.0Prolyl-tRNA synthetase, putative n=14 Tax=Dikarya TaxID=451864 RepID=B9WKB4_CANDC
Q59R20_CANAL63.012%6840.0Proline--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6701 PE=3 SV=1
YHI0_YEAST60.146%6850.0Putative proline--tRNA ligase YHR020W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHR020W PE=1 SV=1
Q6C6Z6_YARLI70.291%5150.0YALI0E05027p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E05027g PE=3 SV=1
A0A1E4TBX2_9ASCO68.472%5170.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_136944 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1164

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 709

Detailed signature matches

  1. Family IPR002316
    Proline-tRNA ligase, class IIa
    1. PR01046 (TRNASYNTHPRO)
  2. Family IPR004499
    Proline-tRNA ligase, class IIa, archaeal-type
    1. TIGR00408
    2. MF_01571 (Pro_tRNA_...)
  3. Domain IPR007214
    YbaK/aminoacyl-tRNA synthetase-associated domain
    1. PF04073 (tRNA_edit)
    2. SSF55826 (YbaK/ProR...)
    3. G3DSA:3.90.96...
  4. Domain IPR006195
    Aminoacyl-tRNA synthetase, class II
    1. PS50862 (AA_TRNA_LI...)
  5. Domain IPR002314
    Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    1. PF00587 (tRNA-synt_2b)
  6. Domain IPR033721
    Prolyl-tRNA synthetase, catalytic domain
    1. cd00778 (ProRS_core...)
  7. Domain IPR004154
    Anticodon-binding
    1. SSF52954 (Class II ...)
    2. G3DSA:3.40.50...
    3. PF03129 (HGTP_antic...)
  8. Domain IPR017449
    Prolyl-tRNA synthetase, class II
    1. SSF64586 (C-termina...)
  9. Domain IPR016061
    Proline-tRNA ligase, class II, C-terminal
    1. SM00946 (ProRS_C_1_2)
    2. PF09180 (ProRS-C_1)
    3. G3DSA:3.30.11...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.93...
  2. SSF55681 (Class II ...)
  3. cd00862 (ProRS_anti...)

Residue annotation

  1. dimer interface cd...
  2. motif 1 cd00778
  3. active site cd00778
  4. motif 2 cd00778
  5. motif 3 cd00778
  6. anticodon binding ...
  7. zinc-binding site ...

Protein sequence

>MIA_06355_1
MSLESQLKSLSLVGDLLEHAAPANNDEWASILAAASQPVPASYELTKTLVFKPKTPKSQAPVPVVVIALNSSATPSSVVA
KATSTKDPRLAAADLVSEFFGGIAPADVGALSVTADNAGKIKVVLDSLIAEPKEDLIVAVHPSAASKTVFIKAADLAAQL
NATGVEVIAVNFAEAAAAAPAPAAPAPKKESASNTAADAKIDGAALIGITVDKDLDFPGWYSQILTKGEMLDYYDVSGCY
IMRPSSYFVWEQIQEFFNTKIKSIGVRNSYFPMFVSSRVLEKEKDHIEGFAPEVAWVTRAGKSELEEPIAIRPTSETVMY
PYYAKWIRSHRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLTFDDANTEVLQILDWYEAIYRELLAVPVIK
GKKTEKEKFAGGFFTTTCEGYIPTTGRGIQGATSHCLGQNFSKMFNITVENPEGPEKPKIFAWQNSWGLSTRVIGVMVMV
HSDNKGLVLPPRVAETQVVVIPVGLTAKSSAEQRQEIQESCRKIEAALSAAGVRVTGDYRDNYSPGWKFADWELRGVPLR
IEFGPQDLKKQQLIAVRRDTGAKLTFGLDSYVSSVQAELEKMQVDLYDKAKASFDGHITKTDSLEKFVPALNSKNVVLAP
FCGEEACEDEIKDKTARQGQEGVEVDEKAPSMGAKSLCIPFEQPELAAGTKCVGCGQPAKFHTLFGRSY

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm