MIA_06089_1

Protein

Length

1,611 amino acids

Browser: contig10:194212-199101-

Protein function

EGGNOG:	0PH2A	FG05697.1	alpha,alpha-trehalose phosphate synthase subunit
SGD closest match:	S000004566	TSL1	Trehalose synthase complex regulatory subunit TSL1
CGD closest match:	CAL0000186940	TPS3	Trehalose 6-phosphate synthase/phosphatase complex subunit

Protein alignments

	%id	Aln length	E-value
MCA_05144_1	48.36%	912	0.0	MCA_05144_1
A0A0J9XIW2_GEOCN	45.21%	898	0.0	Similar to Saccharomyces cerevisiae YML100W TSL1 Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex OS=Geotrichum candidum GN=BN980_GECA17s02232g PE=4 SV=1
UniRef50_A0A0J9XIW2	45.21%	898	0.0	Similar to Saccharomyces cerevisiae YML100W TSL1 Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIW2_GEOCN
A0A167FIH6_9ASCO	50.00%	498	4e-172	Tps3p OS=Sugiyamaella lignohabitans GN=TPS3 PE=4 SV=1
A0A060TA72_BLAAD	50.51%	495	6e-169	ARAD1C43076p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C43076g PE=4 SV=1
TSL1_YEAST	43.68%	522	2e-141	Trehalose synthase complex regulatory subunit TSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSL1 PE=1 SV=1
Q6C3Z3_YARLI	46.08%	497	8e-139	YALI0E31086p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E31086g PE=4 SV=1
A0A1E4TCH9_9ASCO	43.33%	517	1e-136	Glycosyltransferase family 20 protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4083 PE=4 SV=1
A0A1E3PJ59_9ASCO	40.31%	583	3e-131	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83339 PE=4 SV=1
A0A1D8PIS4_CANAL	40.80%	500	4e-129	Trehalose 6-phosphate synthase/phosphatase complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TPS3 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1486

Protein family membership

Trehalose-phosphatase (IPR003337)

Domains and repeats

Domain
272 - 730
Glycosyl transferase, family 20 (IPR001830)

1 200 400 600 800 1000 1200 1400 1611

Detailed signature matches

IPR003337

Trehalose-phosphatase
1. PF02358 (Trehalose_...)
  
  901 - 1,026
  
  Pfam
  PF02358 (Trehalose_PPase)
IPR001830

Glycosyl transferase, family 20
1. PF00982 (Glyco_tran...)
  
  275 - 730
  
  Pfam
  PF00982 (Glyco_transf_20)
2. cd03788 (GT1_TPS)
  
  272 - 730
  
  CDD
  cd03788 (GT1_TPS)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

525 - 715

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)

245 - 524

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)
NON_CYTOPLASM... (N...)

29 - 1,611

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 28

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

11 - 28

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

3 - 10

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 2

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SSF53756 (UDP-Glyco...)

277 - 733

SUPERFAMILY
SSF53756 (UDP-Glycosyltransferase/glycogen phosphorylase)
mobidb-lite (disord...)

1,443 - 1,475

MobiDB Lite
mobidb-lite (disorder_prediction)

155 - 238

MobiDB Lite
mobidb-lite (disorder_prediction)

846 - 889

MobiDB Lite
mobidb-lite (disorder_prediction)

1,119 - 1,145

MobiDB Lite
mobidb-lite (disorder_prediction)

1,574 - 1,606

MobiDB Lite
mobidb-lite (disorder_prediction)

1,183 - 1,205

MobiDB Lite
mobidb-lite (disorder_prediction)

1,317 - 1,416

MobiDB Lite
mobidb-lite (disorder_prediction)

34 - 73

MobiDB Lite
mobidb-lite (disorder_prediction)

86 - 118

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

active site cd03788

291G

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

292G

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

354Y

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

412D

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

414H

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

436H

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

545K

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

550R

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

624Y

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

645L

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

646T

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)

649E

active site
291G, 292G, 354Y, 412D, 414H, 436H, 545K, 550R, 624Y, 645L, 646T, 649E
CDD
cd03788 (GT1_TPS)
homotetramer inter...

538H

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

539M

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

540F

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

541V

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

542A

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

543R

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

544D

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

545K

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

546L

homotetramer interface
538H, 539M, 540F, 541V, 542A, 543R, 544D, 545K, 546L
CDD
cd03788 (GT1_TPS)

Protein sequence

>MIA_06089_1
MTVIVASIFLPYTVKFDLSQCAATAASSASSLSSASSSCASPSSHSSTNLGPPISPGLVNSGGTIHNHGFHAPNITRDTF
APVTAPEEEASPALAVAPSTPSLAPASTPTPSTPLDEKRSVAKALIPDIVQSMDSSNPLAAKKEHKPTLAQELFFGPIVD
SNGAPESTASDPNRRRGELPKAKDPVPRSHIPPHDPANPIEVADPPDPSSGAMHVPIDLPQQPTHQSLLSNAPSSLSSTL
SSQSMARTLLLEKMSMHSARARSRKHTSSADLAATLEKVPWKVDLQRAGNGGLKNAIRRSLAKGCIDSVRWVGSPNIPLE
SITPKTREAITEKLLNSYDSVPVFVSEDTFDGAYATYCKKVLWPTFHYQVPEDAILQTASDKSWEHYQQFNRAVADGILS
IYNEGDVIFINDYHLLLVPQMIREKLPNAKIGFFLHVAFPSSEVFRVLAARREILEGLIAANSIGFQIDEYARHFMQTCN
RILMVDTTPTGIRMNNRFISVNVNPIGMDSENLESYLTNPDVTNFITSIRRTFGHFDHMFVARDKLDPVRGVKEKLEAYE
LFLQEHPEMVDKCVLIQVCLMNKANPELERSVNVIVDRINSLRKSFGTMGPIVFLHQDIEFSRYIALLYEASAFAVTSSR
EGMNLTCHEYIFCNDRYGPLILSEFTGAASELQDGAITVNPWDKREMANAFYLAATMDNYSRRESWERCYEHVIRHTCVD
WIVDFLADLDAAWNEEQRRAAQHVPLLDTLKLIEDYQGHPNKKRIFFLDMDSAIAALPPPAPATAAAAATAAAATSASPS
SQNLSALLNRPHIRRTSSTVSLFDKIEPGLPTMASFKRSSENSKSVTSMVDLLNSDPSSRRSKPPITHRASYLDPRPLPE
ISSSTSSVAGADLKPSKAFLSPQRKISALYELVNDPRNVVYVISSDSRSSLARLFRRVPRIGLIAEDGAYMRRFDQDNPS
WAWLKGTTNPEEPEDDWIELIDWENVNEWKKMMLGMLNDARARLPSMDIEEQDTKIILNLARALPNTPTDSSAPVRKLVK
LGASLEPRSEAEERVFQVIGDVVSHVNDVFESSYNVHARFDSASKTVEISSESASKLGAIKRAFYEEVSRAAGEAYVTST
HEEASHEDLFSPANSQGPTRLAHSHSLGHMHKPHVLGHVLSHNGYYSARGSVSAGSGVNPPIFSTPLSAPHSGSAPDTPL
STASGSCEPNELFELVFIAAEGGDQENDLVLEWGNSLRNGFGLTDGAKAAGGAGAGGPSGGGAADIFGTPSSAATAGGSV
WGTHSTASIFSPSPHANSVSSPFGLLALDNSDVSLTTQSQLQQQQQADQLHHSSVSSGYVSTPLSTLQEGFTLSNTPEGT
SPQSTTGSVVPFPSLSPPPLQVSSSVSSQQHISTTSPNASSTNLGSSATPPPAPLQTTLLRRSSSIASRTAIFSVDLGLS
QQPSHLETQSPTPMSPASLSPAHSGSPPFPLQQQPKLSLNTTGVTRARRGTGLASHHSGVVGAGTNALLVPEPAVYTVSV
GGTGTYAESEVDGVNGLLTAIINAVRGSVGSAGSTGSLGTGWSAGSSASFSASAGSEATSRAATSSSGTTDSQEGENQYV
FPETGDDFWAI

GO term prediction

Biological Process

GO:0005992 trehalose biosynthetic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features