MIA_05801_1

Protein

Length

388 amino acids

Protein function

EGGNOG:	0PGUV	FG05467.1	4,6-dehydratase
SGD closest match:	S000000223	GAL10	Bifunctional protein GAL10
CGD closest match:	CAL0000194591	GAL102	Gal102p

Protein alignments

	%id	Aln length	E-value
MCA_00504_1	63.483%	356	1.44e-161	MCA_00504_1
A0A0J9XI90_GEOCN	57.851%	363	1.32e-149	Similar to Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase OS=Geotrichum candidum GN=BN980_GECA18s01066g PE=4 SV=1
UniRef50_C7ZAZ2	51.136%	352	5.13e-122	Putative uncharacterized protein n=8 Tax=Sordariomycetes TaxID=147550 RepID=C7ZAZ2_NECH7
A0A060T4J8_BLAAD	50.997%	351	2.04e-121	ARAD1C41184p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C41184g PE=4 SV=1
A0A167DAS1_9ASCO	55.147%	272	4.38e-105	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_957 PE=4 SV=1
A0A1E4TL87_9ASCO	44.444%	342	1.46e-101	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_21605 PE=4 SV=1
Q59VY4_CANAL	38.415%	328	3.30e-73	Gal102p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GAL102 PE=4 SV=1
F2Z651_YARLI	38.081%	344	3.51e-72	YALI0D25080p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D25080g PE=4 SV=1
GAL10_YEAST	26.074%	326	1.12e-13	Bifunctional protein GAL10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAL10 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0972

Protein family membership

None predicted.

Domains and repeats

Domain
47 - 381
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 388

Detailed signature matches

IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  48 - 370
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
2. SSF51735 (NAD(P)-bi...)
  
  47 - 381
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

46 - 235

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

236 - 388

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05246 (dTDP_GD_SDR_e)

47 - 376

CDD
cd05246 (dTDP_GD_SDR_e)

Residue annotation

NAD binding site c...

51G

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

53L

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

54G

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

55F

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

56I

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

77D

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

78N

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

79R

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

80G

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

82C

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

83S

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

102C

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

103D

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

104V

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

125M

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

126A

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

127A

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

129S

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

144T

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

180M

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

181S

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

182T

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

208Y

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

212K

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

235C

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

236N

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

237N

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)

238I

NAD binding site
51G, 53L, 54G, 55F, 56I, 77D, 78N, 79R, 80G, 82C, 83S, 102C, 103D, 104V, 125M, 126A, 127A, 129S, 144T, 180M, 181S, 182T, 208Y, 212K, 235C, 236N, 237N, 238I
CDD
cd05246 (dTDP_GD_SDR_e)
substrate binding ...

129S

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

130H

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

131V

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

182T

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

183D

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

184E

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

208Y

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

235C

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

236N

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

237N

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

246E

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

247K

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

248I

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

251R

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

252F

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

263T

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

264L

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

265H

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

270N

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

272R

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

307N

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

340R

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

343N

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)

347Y

substrate binding site
129S, 130H, 131V, 182T, 183D, 184E, 208Y, 235C, 236N, 237N, 246E, 247K, 248I, 251R, 252F, 263T, 264L, 265H, 270N, 272R, 307N, 340R, 343N, 347Y
CDD
cd05246 (dTDP_GD_SDR_e)
homodimer interfac...

133H

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

135F

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

138P

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

139S

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

142T

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

146V

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

147I

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

150Q

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

154E

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

157K

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

188E

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

199S

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

201I

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

202L

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

204P

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

205T

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

206N

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

207P

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

210A

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

213A

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

214A

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

217M

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

218Y

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

221A

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

222Y

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

224K

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

225S

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

226F

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)

344D

homodimer interface
133H, 135F, 138P, 139S, 142T, 146V, 147I, 150Q, 154E, 157K, 188E, 199S, 201I, 202L, 204P, 205T, 206N, 207P, 210A, 213A, 214A, 217M, 218Y, 221A, 222Y, 224K, 225S, 226F, 344D
CDD
cd05246 (dTDP_GD_SDR_e)
active site cd05246

145N

active site
145N, 182T, 208Y, 212K
CDD
cd05246 (dTDP_GD_SDR_e)

182T

active site
145N, 182T, 208Y, 212K
CDD
cd05246 (dTDP_GD_SDR_e)

208Y

active site
145N, 182T, 208Y, 212K
CDD
cd05246 (dTDP_GD_SDR_e)

212K

active site
145N, 182T, 208Y, 212K
CDD
cd05246 (dTDP_GD_SDR_e)

Protein sequence

>MIA_05801_1
MTTAPLIKQHDDTITTPSSSSSQSFDETAAQYIGTTKFEPDPNISSILLTGGLGFIPSWLVRHLVFTYPAYRIVCIDNRG
YCSSLNNIAVCRSQPNFVFEQCDVTDRARVLEIMHKHKVDAVIHMAAESHVDHSFGNPSRFTSTNVIGTQTMLEATKIIN
EEVAESPGSGRRRICKFIHMSTDEVYGESVDSEEDLLESAILVPTNPYAASKAAGDMYVNAYLKSFGVPAIIVRCNNIYG
PMQFPEKIIPRFIRLLQQGQKLTLHGNGSNLRRYLYVLDAVDALDTILHRGTVGRIYNAGSQNELTNKEVARVLLVKSGK
LPPQCTQQDMLPFIEFTKDRPFNDARYAIDSTRLQKLGWVPRIDFNQGIQLTIDWYNQKTDEWWDVQV

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_05801_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component