Protein
MIA_05446_1
Length
1,043 amino acids
Browser: contig08:492041-495173+
Protein function
| EGGNOG: | 0PH6S | PPM2 | S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity) |
|---|---|---|---|
| SGD closest match: | S000005501 | PPM2 | tRNA wybutosine-synthesizing protein 4 |
| CGD closest match: | CAL0000175964 | PPM2 | tRNA wybutosine-synthesizing protein 4 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_00740_1 | 53.07% | 1042 | 0.0 | MCA_00740_1 |
| A0A0J9X425_GEOCN | 50.10% | 1028 | 0.0 | Similar to Saccharomyces cerevisiae YOL141W PPM2 AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation OS=Geotrichum candidum GN=BN980_GECA02s03387g PE=4 SV=1 |
| UniRef50_A0A0J9X425 | 50.10% | 1028 | 0.0 | Similar to Saccharomyces cerevisiae YOL141W PPM2 AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X425_GEOCN |
| A0A170QZG0_9ASCO | 41.67% | 1020 | 0.0 | Ppm2p OS=Sugiyamaella lignohabitans GN=PPM2 PE=4 SV=1 |
| TYW4_YARLI | 38.90% | 1018 | 0.0 | tRNA wybutosine-synthesizing protein 4 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PPM2 PE=3 SV=1 |
| A0A1E3PPQ3_9ASCO | 41.84% | 686 | 1e-152 | LCM-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49845 PE=4 SV=1 |
| A0A060T8B4_BLAAD | 36.84% | 684 | 8e-128 | ARAD1D09834p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D09834g PE=4 SV=1 |
| TYW4_YEAST | 33.04% | 678 | 5e-96 | tRNA wybutosine-synthesizing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPM2 PE=1 SV=2 |
| TYW4_CANAL | 33.43% | 697 | 7e-95 | tRNA wybutosine-synthesizing protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPM2 PE=3 SV=1 |
| A0A1E4TII6_9ASCO | 32.10% | 673 | 8e-71 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1017
Protein family membership
- Methyltransferase Ppm1/Ppm2/Tcmp (IPR007213)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
900
1043
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
PF13418 (Kelch_4)
-
PF13621 (Cupin_8)
-
SSF117281 (Kelch motif)
-
SSF51197 (Clavamina...)
-
mobidb-lite (disord...)
Protein sequence
>MIA_05446_1 MALEEPKISKNLSGNQQKSNKSKNGKPTQRLVKSKVTARNEKIQGTNDSSIVSKRSVERLYWSKRTPGINGKLIKDQKTI VEFFRPFVSKPQRRSPTINRGYWTRMEAIMNHIEFTINSSPYPRNVVVGLGAGFDPYPFQYLYNHAEEKSSEIVFLDVDF PDLIKRKVSMIQQAPEVLNVIGEQLPIPENLKDMVQLRTSSYIALGCDLTKLNDFTKALETLFDPEKTVFTFTAEVSITY MPQKDADSVIEWASKFKHSRFVLLEQILPSGPTHPFAKTMLKHFNQLNTPLNSVLKYQKVSDQKNRFKSLSWATVQASDL ATFYDTAITDEQKEFLDSIEAFDEWEEFILFCQHYVILFASTNTLDQSPFIKEFSPVNTTITKSFQNIITNAAPSSFHKK FAGGSNFSSNSLIVNGGLSISRTNDSVLISTESSTPFVMEQETFQERMCHTLTYLEKSNQIMLVGGRLAPNKPLSDCWLL SGSKWEKVQDLTSPRYRHHSIATKDDDVIVFGGRGLKTDTMDWVIFSSGVWKSLNSIGDELPNLYSSATAWDKASSRGYI FGGHLNDNTLNTRIYYFEVSSNVKIVDISSQFDTESRLLLSRVGAKACYLNGLVYVVGGVNNSQVKDMNYTAVEFDPENG NVSPLRFTENLLDSSSLETSPILVGFNMDVINESLVTYGGGAVCFSFGSFWDNVTIFQPHESNLKNLHIIHKSAKLVTAI PEKKEHRLISTIPSPVTEVNLDSIGSTFQDFLEKVYVKQVPQVFRGLNLGPCLKNWKDPDYLIKTVGEDYKIIAHISEAS NMNFAAKNFEYKTMPFGDFISNVFTQDNSKKYYLRSLSVDNPKTHPAIFRQDFPQLEQDFILPPSLENLNQVQFSSPLRI ATPHTAIWLHYDVTANVLFQIVGRKTVRLYAPSEVSHLHISPGASTSVIEDIFACNSNDLSLNSQPFEVELHPGDAIFIP ACWLHAIRSEESSISLNYFWRDLDTRHYAAGKDVYGNRDLAGYEQGRTMINKLISSFDGTPLEVKKFYLQRLADELNNCI HNL
GO term prediction
Biological Process
GO:0032259 methylation
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Cellular Component
None predicted.