Protein

MIA_05250_1

Length
1,030 amino acids

Browser: contig07:1128848-1132141-

Protein function

EGGNOG:0PFPPHHK5Histidine kinase
SGD closest match:S000001409SLN1Osmosensing histidine protein kinase SLN1
CGD closest match:CAL0000175114SLN1Histidine protein kinase SLN1

Protein alignments

%idAln lengthE-value
MCA_04716_162.791%6880.0MCA_04716_1
A0A0J9XJP7_GEOCN51.084%7380.0Similar to Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade OS=Geotrichum candidum GN=BN980_GECA19s02188g PE=4 SV=1
UniRef50_A0A0J9X59449.054%7400.0Similar to Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X594_GEOCN
A0A060TCE8_BLAAD42.496%6737.81e-129ARAD1D41294p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D41294g PE=4 SV=1
Q6CB75_YARLI34.479%8442.41e-100YALI0C21340p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C21340g PE=4 SV=1
A0A1E3PMZ3_9ASCO34.633%6417.78e-84Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82171 PE=4 SV=1
A0A167CAF7_9ASCO65.865%2083.94e-70Sln1p OS=Sugiyamaella lignohabitans GN=SLN1 PE=4 SV=1
A0A1E4TA96_9ASCO41.926%3531.20e-56Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_127796 PE=4 SV=1
SLN1_CANAL56.098%2052.58e-54Histidine protein kinase SLN1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SLN1 PE=1 SV=1
SLN1_YEAST51.923%2081.96e-43Osmosensing histidine protein kinase SLN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLN1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5875
Predicted cleavage: 64

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 800 900 1030

Detailed signature matches

  1. Domain IPR003661
    Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
    1. cd00082 (HisKA)
    2. SSF47384 (Homodimer...)
    3. SM00388 (HisKA_10)
    4. PF00512 (HisKA)
  2. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
  3. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  4. Domain IPR004358
    Signal transduction histidine kinase-related protein, C-terminal
    1. PR00344 (BCTRLSENSOR)
  5. Domain IPR011006
    CheY-like superfamily
    1. SSF52172 (CheY-like)
  6. Domain IPR001789
    Signal transduction response regulator, receiver domain
    1. PS50110 (RESPONSE_R...)
    2. PF00072 (Response_reg)
    3. cd00156 (REC)
    4. SM00448 (REC_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:1.10.28...
  4. G3DSA:3.40.50...
  5. NON_CYTOPLASM... (N...)
  6. SIGNAL_PEPTIDE (Sig...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. TMhelix
  11. TRANSMEMBRANE (Tran...)
  12. cd00075 (HATPase_c)
  13. mobidb-lite (disord...)

Residue annotation

  1. dimer interface cd...
  2. phosphorylation si...
  3. ATP binding site c...
  4. Mg2+ binding site ...
  5. G-X-G motif cd00075
  6. active site cd00156
  7. phosphorylation si...
  8. intermolecular rec...
  9. dimerization inter...

Protein sequence

>MIA_05250_1
MKLHVLHFFQKRSNKRSGPIFIGIKWQLSLLACVSALCALGALAVATSVVNHSTVLNLRSDRLKVVAQLKAAQVSQVLSL
LLGDLIVLSSRNFIHTLLTNYYTGEQVNSVNEVDFQMLLKTTDNSIAGAIYSYNTSLVIYKTNNDTLPQSVTLPASLFPL
NNTDSSSDISSLNDGNSIIRGPRMVNSSFYLSITRALNTQSSDGQIVSGSILGYLTIVSKATGLLNVVTTSDLEDGSRLS
LIKLGVNGTRSTIDKSTLTNLNYTYVTPSLMCITCYNYQFPLTIGTPEYLALVNGTSGAFINYNIPQYGMVSTGYAPVST
FWQIWGVVVFQPHKYVYGPIRTIQKISIISVFSIGAGVCVLTLLLSGWVLRPITRLQAATEQSYGDSHRSRGFWHFFKNI
FLSLFKLKRFSKSKIEFKEKSMQGNSASYNYKGRFQEDVPEFRLPEKIITRKHIRDELTELTETFNEMTIELRKQYKNLE
ERVQQRTKEIKTAKSLAETANEAKSLFIANITHELRTPLNGILGMAAVAMEEDDPQSVRESLKVIFKSGELLLRLLTDLL
SFSKSEVDNMKLEMKGFSISEIISQLHAIFDENSKVAKINFSILMKSEWLLKYEVNGDINRILQVVINLVSNSLKFTPSG
GFVKVIISAGKNDDNDLSTSESSSSDEFDDHSSDTEHKETDCDTSGKTVVSFVVCDSGSGIAPHLQSRVFEPFVQGDIGA
KETRSGAGLGLSICRHLATLMDGAIDLKSEVGSGSCFTFKVPMEYKLISANHEDSDVEILSNHQISSDFGIAEMNTNQEE
DHDKILSSVSQYQPEVLQSTSLVSSSVEPSAKIEEKRELNFEYNKPVNSLSQNISSPSFPMDPVKIGSYPHMYSSAHANN
NSTSNINSQHSKKTLDPKICDDLHVLIAEDNRVNQEVMVKMLHLEGIKNVKVANDGLQAVSAVENKIKEFDIIFMDIQMP
NMDGIQATEKIRNTLGYKGPIIAVSAYTDKSNVDKCLEAGVNDFLGKPLRRQQLHSMLEILVEKKLEHHL

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.