MIA_05196_1

Protein

Length

502 amino acids

Protein function

EGGNOG:	0PFT2	FG01986.1	transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000180798	TNA1	Tna1p

Protein alignments

	%id	Aln length	E-value
MCA_01039_1	73.031%	508	0.0	MCA_01039_1
A0A0J9X623_GEOCN	71.343%	499	0.0	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA02s07710g PE=4 SV=1
A0A1E4TD78_9ASCO	55.556%	504	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142936 PE=4 SV=1
UniRef50_A0A1E4TD78	55.556%	504	0.0	Uncharacterized protein n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E4TD78_9ASCO
Q6C031_YARLI	47.368%	418	7.87e-122	YALI0F28193p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F28193g PE=4 SV=1
A0A1E3PD75_9ASCO	40.864%	509	9.41e-118	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_29178 PE=4 SV=1
A0A167EMY7_9ASCO	41.133%	406	9.10e-103	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
A0A060SZZ6_BLAAD	37.000%	400	1.23e-94	ARAD1C12562p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C12562g PE=4 SV=1
A0A1D8PNL8_CANAL	36.689%	447	9.17e-76	Tna1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TNA1 PE=4 SV=1
TNA1_YEAST	31.421%	401	1.08e-61	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0100

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
35 - 470
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 502

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  57 - 426
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  52 - 470
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  35 - 470
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  53 - 429
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

112 - 117

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

398 - 408

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

343 - 348

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

234 - 284

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

464 - 502

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 47

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

167 - 177

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

261 - 493

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

40 - 249

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

71 - 89

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

200 - 210

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

138 - 142

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

306 - 324

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

431 - 441

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

370 - 374

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

349 - 371

TMHMM
TMhelix (TMhelix)

320 - 342

TMHMM
TMhelix (TMhelix)

178 - 200

TMHMM
TMhelix (TMhelix)

210 - 232

TMHMM
TMhelix (TMhelix)

375 - 397

TMHMM
TMhelix (TMhelix)

89 - 111

TMHMM
TMhelix (TMhelix)

143 - 165

TMHMM
TMhelix (TMhelix)

409 - 431

TMHMM
TMhelix (TMhelix)

441 - 463

TMHMM
TMhelix (TMhelix)

118 - 137

TMHMM
TMhelix (TMhelix)

48 - 65

TMHMM
TMhelix (TMhelix)

283 - 305

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

409 - 430

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

178 - 199

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

211 - 233

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

90 - 111

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

285 - 305

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

349 - 369

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

442 - 463

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

325 - 342

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

375 - 397

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

48 - 70

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

118 - 137

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

143 - 166

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

67R

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

70I

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

71G

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

72N

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

75I

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

76A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

93L

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

96F

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

97F

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

100Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

104E

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

105A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

107C

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

108N

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

154E

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

155A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

158M

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

159P

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

162A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

163Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

166S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

178I

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

179A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

182F

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

183S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

189G

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

296T

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

299I

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

300Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

303S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

304Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

307P

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

320A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

324S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

328Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

331A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

335T

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

384T

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

387Q

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

388Y

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

391W

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

395V

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

396S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

399A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

411A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

412M

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

415Q

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

416I

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

419A

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

420S

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

423G

putative substrate translocation pore
67R, 70I, 71G, 72N, 75I, 76A, 93L, 96F, 97F, 100Y, 104E, 105A, 107C, 108N, 154E, 155A, 158M, 159P, 162A, 163Y, 166S, 178I, 179A, 182F, 183S, 189G, 296T, 299I, 300Y, 303S, 304Y, 307P, 320A, 324S, 328Y, 331A, 335T, 384T, 387Q, 388Y, 391W, 395V, 396S, 399A, 411A, 412M, 415Q, 416I, 419A, 420S, 423G
CDD
cd06174 (MFS)

Protein sequence

>MIA_05196_1
MSLEFEKKPEAYYEEVVVPSDKNFSSLEEQQIVESFDKKKIDRLRLKIDFNLIPACAMLYLLCFLDRGNIGNAKIAGMTT
DLNMTSHDYSVVLVVFFATYCTVEAPCNMLLKKMSPKIFLPLICFLWGICVMCMGFAKNTGHLIALRVLLGLFEAGLMPG
CAYYLSNWYRSTELSYRIALFFSSATIAGAFSGILAWAIMKMDGVGGLAGWSWIFILEGIATIVVGCACYFIIYNGPQHA
RFLNEEEVVFWEWYLKQDVGKGNDKIDNERLGWKHIKDGVFHWRVWYMVILSLGCTVPIYSFSYFLPTIINTLGWTASKA
QLMSAPPYIWACLCTIAVSYISDKYKSRYIFVIAPMILFAIPGFSIALGQSRSGVTYAGVFLATAGQYAPWPSIVSWNAN
NYPNAHTRGIAMGIQIGFASAGGIIASFIYRAQDKPRYKLGHSVVLGVTVLASALALALAAYYKVANKKKEKYCEEHPEV
YDEDPHVLAQMETKNPLFRYQI

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

Filter view on

Entry type

Status

Per-residue features