MIA_05185_1

Protein

Length

452 amino acids

Protein function

EGGNOG:	0PIR7	UXS1	UDP-glucuronic acid decarboxylase
SGD closest match:	S000000223	GAL10	Bifunctional protein GAL10
CGD closest match:	CAL0000194591	GAL102	Gal102p

Protein alignments

	%id	Aln length	E-value
MCA_06260_1	71.540%	383	0.0	MCA_06260_1
A0A0J9X3A7_GEOCN	70.976%	379	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s08414g PE=4 SV=1
Q6CA72_YARLI	65.829%	398	0.0	YALI0D05335p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D05335g PE=4 SV=1
A0A1E4TL70_9ASCO	57.560%	377	5.81e-163	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30638 PE=4 SV=1
UniRef50_A0A1S8W1A3	59.730%	370	4.12e-157	Uncharacterized protein n=1 Tax=Batrachochytrium salamandrivorans TaxID=1357716 RepID=A0A1S8W1A3_9FUNG
A0A060T4J8_BLAAD	28.045%	353	2.59e-24	ARAD1C41184p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C41184g PE=4 SV=1
Q59VY4_CANAL	26.332%	319	5.45e-17	Gal102p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GAL102 PE=4 SV=1
A0A167DAS1_9ASCO	26.718%	262	1.11e-12	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_957 PE=4 SV=1
GAL10_YEAST	25.000%	356	2.71e-10	Bifunctional protein GAL10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAL10 PE=1 SV=2
A0A1E3PTD8_9ASCO	22.254%	355	1.93e-07	UDP-glucose 4-epimerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49320 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4419

Protein family membership

None predicted.

Domains and repeats

Domain
127 - 446
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 400 452

Detailed signature matches

IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  136 - 439
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
2. SSF51735 (NAD(P)-bi...)
  
  127 - 446
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

130 - 299

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

300 - 451

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
cd05230 (UGD_SDR_e)

133 - 444

CDD
cd05230 (UGD_SDR_e)

Residue annotation

NAD binding site c...

139G

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

141A

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

142G

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

143F

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

144V

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

163D

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

164N

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

165Y

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

166F

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

167T

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

168G

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

187H

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

188D

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

189V

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

203L

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

204A

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

205C

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

206P

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

207A

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

222T

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

244A

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

245S

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

246T

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

275Y

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

279K

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

302I

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

303F

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

304N

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

305T

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)

316R

NAD binding site
139G, 141A, 142G, 143F, 144V, 163D, 164N, 165Y, 166F, 167T, 168G, 187H, 188D, 189V, 203L, 204A, 205C, 206P, 207A, 222T, 244A, 245S, 246T, 275Y, 279K, 302I, 303F, 304N, 305T, 316R
CDD
cd05230 (UGD_SDR_e)
putative substrate...

192P

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

193I

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

228Y

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

229N

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

232G

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

233L

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

235K

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

236R

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)

289Y

putative substrate binding site 2
192P, 193I, 228Y, 229N, 232G, 233L, 235K, 236R, 289Y
CDD
cd05230 (UGD_SDR_e)
putative substrate...

209P

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

272R

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

304N

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

315G

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

316R

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

317V

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

320N

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

321F

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

332T

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

333V

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

334Y

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

339S

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

341R

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

378I

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

409D

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)

413R

putative substrate binding site 1
209P, 272R, 304N, 315G, 316R, 317V, 320N, 321F, 332T, 333V, 334Y, 339S, 341R, 378I, 409D, 413R
CDD
cd05230 (UGD_SDR_e)
active site cd05230

223G

active site
223G, 246T, 275Y, 279K
CDD
cd05230 (UGD_SDR_e)

246T

active site
223G, 246T, 275Y, 279K
CDD
cd05230 (UGD_SDR_e)

275Y

active site
223G, 246T, 275Y, 279K
CDD
cd05230 (UGD_SDR_e)

279K

active site
223G, 246T, 275Y, 279K
CDD
cd05230 (UGD_SDR_e)

Protein sequence

>MIA_05185_1
MISQNLKNSVVDTTSGSSALNIPAKKPLAATAPSFSSSCDTLTPSSDLFNPPPLLASSSSSSSYPAFSPPSNVNVKASLT
KTYSGTSEQELLYMSSDISYADLKRLYTLNPLASAKTTAKYPAVRTLNPFQKKRILVTGGAGFVGSHLVDRLMLMGHDVL
CIDNYFTGHKANVAQWVGHPNFELIRHDVIDPIMLEVDQIYHLACPASPVHYQSNPVKTLKTGFLGTYNMLGLAKRVKAR
ILIASTSEIYGDPLEHPQRESYWGNVNIQGPRACYDESKRVGETLAYSYMMQEQVDVRVARIFNTYGPRMNWNDGRVVSN
FILQALKNEDLTVYGSGDSTRSFQYVMDLVDGLIELMNCDAPTASEPVNIGNPEEYTIAQFAQKTIDLVKAVTGKCDSRI
VYLDPLVDDPHRRKPDTTRARELLGWRPKWSVERGMRETIEYFKWQVEIMSS

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_05185_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component