Protein
MIA_05057_1
Length
793 amino acids
Browser: contig07:588993-591375-
Protein function
| EGGNOG: | 0PFWK | PAB1 | Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000967 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
| CGD closest match: | CAL0000195952 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_06035_1 | 45.434% | 438 | 2.81e-97 | MCA_06035_1 |
| A0A060TBG3_BLAAD | 37.757% | 437 | 3.48e-77 | ARAD1D31548p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D31548g PE=4 SV=1 |
| A0A0J9X6A7_GEOCN | 41.067% | 431 | 5.16e-75 | Similar to Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein, part of the 3'-end RNA-processing complex OS=Geotrichum candidum GN=BN980_GECA03s00142g PE=4 SV=1 |
| UniRef50_A0A0J9X6A7 | 41.067% | 431 | 1.06e-71 | Similar to Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein, part of the 3'-end RNA-processing complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X6A7_GEOCN |
| A0A1E4T9Q8_9ASCO | 34.988% | 423 | 7.69e-66 | Polyadenylate-binding protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_70868 PE=3 SV=1 |
| PABP_YARLI | 33.333% | 426 | 3.72e-61 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAB1 PE=3 SV=1 |
| PABP_YEAST | 34.204% | 421 | 2.00e-61 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAB1 PE=1 SV=4 |
| A0A167EIC1_9ASCO | 32.857% | 420 | 5.21e-58 | Polyadenylate-binding protein OS=Sugiyamaella lignohabitans GN=PAB1 PE=3 SV=1 |
| PABP_CANAL | 33.967% | 421 | 2.74e-58 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAB1 PE=3 SV=1 |
| A0A1E3PFY9_9ASCO | 32.464% | 422 | 8.80e-58 | Polyadenylate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47563 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0096
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
793
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
-
cd00590 (RRM_SF)
-
mobidb-lite (disord...)
Protein sequence
>MIA_05057_1 MSDSTSPIPATSSPKKDPVEQLHAPATTTTPGQTEDAPSLATEPTTSSTTTNTTSSSQQQQLPPTSIGADRDPDASIYIS EIDQTVNEADLFDIFSAYGNILSIRVAKDPLSRASLGYAYVNYTFPQDAAAALAYDFALIHNKPCRVSAFQKDPTRRKAP PKTAVYIRNLEPSVSVEELKTRFAPYGPIVAAKVAPVPARFDPSDLAHDANNNDTQSSPQYVFSYGCVEYETPEQALAAI KAENGTPFGSRTIYTSHHVSRRNTDRPPRQPHHHHHHHHNHNHHNFHNNDNIPDDYTNLLVKNIDPSAPDQEFLDLFAQH GEIASHTLPIDPKTGTRKGFGFVAFKTHDAAANAQQALNLSQFYGAELTVSPAQQHHPHHHNYRRSDDSLRRNSPGPSTG SPSPAPFTTPTNNTTNLYIKYLDIAIDDAELRRLFAPHGTISSARVMLDESGQSRGFGFVCYTSPAEAQTAIAEMHGAEV SGKSLYVTIAQRRDKHPGGLLRGHRGVSRNNNANPLYIQQPQQQPHQHQQQQQQHHHHHHSHQQAAFTAAPFFSPYYLAA AAAAAAGMPAPPPPPPPGSAPGGAQGSMIYTPYGAAGYPAMMALGTQLPPPQAFRKPVGAGNRSSGPGSSNAGPGDKKYN GNGRYYGNSPGNGNGIPASSNAGARQQGSVASGGTSPVAGSPNVHLPAAATSSASASSTAVPASTTLSAALASAANPEAE RQVIGEALYPKVQRHVAVRNDSELAAKLTGMMLDIAAEELLRWIDDDAVLAAQIQEAYDQYMEFLKNKDDDAE
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Cellular Component
None predicted.