Protein

MIA_04896_1

Length
1,438 amino acids

Browser: contig07:107929-112246-

Protein function

EGGNOG:0QDPVLTE1Guanine nucleotide exchange factor
SGD closest match:S000000022LTE1Guanine nucleotide exchange factor LTE1
CGD closest match:CAL0000195455LTE1Mitotic regulator

Protein alignments

%idAln lengthE-value
A0A0J9XEH4_GEOCN56.592%3114.21e-107Similar to Saccharomyces cerevisiae YAL024C LTE1 Protein similar to GDP/GTP exchange factors but without detectable GEF activity OS=Geotrichum candidum GN=BN980_GECA12s00714g PE=4 SV=1
UniRef50_A0A0J9XEH456.592%3118.61e-104Similar to Saccharomyces cerevisiae YAL024C LTE1 Protein similar to GDP/GTP exchange factors but without detectable GEF activity n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XEH4_GEOCN
A0A167CPZ1_9ASCO55.872%2817.08e-98Mitotic regulator LTE1 OS=Sugiyamaella lignohabitans GN=LTE1 PE=4 SV=1
Q6C3H8_YARLI52.206%2726.20e-87YALI0E34727p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E34727g PE=4 SV=1
A0A1D8PHR4_CANAL45.548%2924.23e-77Mitotic regulator OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LTE1 PE=4 SV=1
A0A060TBN1_BLAAD48.507%2686.61e-71ARAD1D36388p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36388g PE=4 SV=1
MCA_03589_135.366%4101.89e-66MCA_03589_1
A0A1E3PDZ2_9ASCO55.556%1892.85e-63Ras GEF OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47982 PE=4 SV=1
LTE1_YEAST38.372%2588.72e-56Guanine nucleotide exchange factor LTE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LTE1 PE=1 SV=2
A0A1E4TAP2_9ASCO28.824%1702.33e-14Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13579 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4324
Predicted cleavage: 16

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1438

Detailed signature matches

  1. Domain IPR023578
    Ras guanine nucleotide exchange factor domain
    1. SSF48366 (Ras GEF)
  2. Domain IPR000651
    Ras-like guanine nucleotide exchange factor, N-terminal
    1. SM00229 (rasgefn_5)
    2. cd06224 (REM)
    3. PS50212 (RASGEF_NTER)
    4. PF00618 (RasGEF_N)
  3. Domain IPR001895
    Ras guanine-nucleotide exchange factors catalytic domain
    1. PF00617 (RasGEF)
    2. SM00147 (RasGEF_3)
    3. PS50009 (RASGEF_CAT)
    4. G3DSA:1.10.84...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.87...
  2. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...

Protein sequence

>MIA_04896_1
MSLSVAPAKDAAVRRPPINLPPIHITSLLATPPSSATSSATPPNVPPKCLFPLGLPTPDSDQSDSDITPAISPILACPFP
TPSYPPTIFNSLSLSDSSKIRFDPSSALLTAATPQMLVLYLTSHNVLDYDLLSDFFLTYRLFLDPASLLELVFARLAWAI
STHAQAPLLELGRDVAVRTFVLIRHWVLNFFPDDFVPSYPLRLRFAQCANALYSWPPVQATPAFLLILAQLKKSWLRSCA
LYWDMDPPSSSAPPNFSYPRPQTLPVSPGGKVGSISMAPTKSSPTKSASSRRTTMLSLYQVPIKPILTNTDPLLKSAGFG
IMDGSLIKGGISLSTDATVTSFSPPTPVPSLLIPPSLLPPQQSPPPQHLPTHKPHKSIRTIMENWKRELGHHKNKAISKF
FSKVVHISKEDSLVSQDDPDQSTLDEQPQPLKETHLPPPQIPNPSPIPPHTPRIDVLSARVIQELEAIVKARESPDDDDS
DDATSIDSHKSGEQLPVSSNSDSRVSLIDSLNMRAYFSPKRTRTVPSVNRQNSVASSISSGVFVSAKTSPQKLKASPSFA
STFSPVPECKTPSPSPSFCLAPSLSTYRIPVFSPPPQPSTPNLSPKTSAPSRFSIRSYDSYDSRASSSPKSPTKPALPPA
NGLTGGLRRVGHLNLSPPAFYLAPGESNSMLAQTIARDLGADLDDTTIDPTLLPHHNPILPGGLSPDIVAELAQIPDDYD
DDNTATPNAVAYALSKLEGTCPPHKTTPFEQNLSMQLAHLPIVAPLHIRSQTPISSPITRPLSATTPVRPSRNTSNLDAS
SPLRPRPHSSPQSLANLSRTAAPEITTTNATLSTIAPSNPPGSTDTSFLLKSSQFCDTYTPPQEVSSSSPTQMRVPGRAL
SYVTSAASSPITDDFLLFNFSSGSSLYQDAFETPKPADPNAFSRSSSLLDDDYYPGNTDSMAHRRAPTRFLRSSKSVSQL
LSRRSSAASSYGNGGGGSNSEENLLFGHASRNNSLALAMGFPTMFEEDEDPQASVSSTTTKPIRRLFASQSSAPRPGITR
STTGNLLRRGPSLRRDPVHAPKAHSLFDLHAHKDHPLDNDNDDMSHKDTAFDRVSEQSLGPPKQASTPPLGSSSETSFGS
TTPPAHHSSAISLLPSPVMSTETTPPDMPSPEEDDEADPLSIAATVPSGSHAPFILHYGSRVLTEQLTLVERDALAEVDW
KELVEMQWPRTVIPVQSWLGYLVESQPPPDAPDEGPHGAAVVIARFNLMVNWVKSEILLTRSLADRSCAVARFIHVAHHA
RQLQNYATVVQIVLALTSSTIRSLARTWAAVPAADRAMLAALEHLVSPLRNFKNLRSELSNLDAARGCIPFLGIYLSDLT
ANAERPKYVGGQEGGLVNMARFRTSASVVKSLMQCIEWAGNYDLVPDYDLLAKCLYIQSLTEDEMNECFQYLDESRGS

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.