Protein

MIA_04760_1

Length
518 amino acids

Browser: contig06:922579-924136-

Protein function

EGGNOG:0PHMEPDI1Protein disulfide isomerase
SGD closest match:S000000548PDI1Protein disulfide-isomerase
CGD closest match:CAL0000178400PDI1Protein disulfide isomerase

Protein alignments

%idAln lengthE-value
MCA_03045_155.044%4561.49e-174MCA_03045_1
A0A0J9X7R7_GEOCN49.670%4554.50e-148Similar to Saccharomyces cerevisiae YCL043C PDI1 Protein disulfide isomerase OS=Geotrichum candidum GN=BN980_GECA04s05609g PE=4 SV=1
UniRef50_A0A0J9X7R749.670%4559.21e-145Similar to Saccharomyces cerevisiae YCL043C PDI1 Protein disulfide isomerase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7R7_GEOCN
A0A060T118_BLAAD49.559%4547.85e-136Protein disulfide-isomerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C13090g PE=3 SV=1
Q6C781_YARLI46.171%4578.84e-123Protein disulfide-isomerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E03036g PE=3 SV=1
A0A167FDN5_9ASCO44.589%4625.79e-115Protein disulfide-isomerase OS=Sugiyamaella lignohabitans GN=PDI1 PE=3 SV=1
A0A1E3PQF1_9ASCO41.256%4465.23e-101Protein disulfide-isomerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45717 PE=3 SV=1
PDI_YEAST41.277%4702.14e-96Protein disulfide-isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDI1 PE=1 SV=2
A0A1E4TBP4_9ASCO41.189%4541.91e-94Protein disulfide-isomerase (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16522 PE=3 SV=1
A0A1D8PR99_CANAL35.565%4781.51e-79Protein disulfide isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDI1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1068

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 518

Detailed signature matches

  1. Family IPR005792
    Protein disulphide isomerase
    1. TIGR01130
  2. Domain IPR012336
    Thioredoxin-like fold
    1. SSF52833 (Thioredox...)
  3. Domain IPR013766
    Thioredoxin domain
    1. PF00085 (Thioredoxin)
    2. PS51352 (THIOREDOXIN_2)
  4. Domain IPR005788
    Disulphide isomerase
    1. TIGR01126
  5. SITE IPR017937
    Thioredoxin, conserved site
    1. PS00194 (THIOREDOXIN_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.30.10
  2. NON_CYTOPLASM... (N...)
  3. PF13848 (Thioredoxin_6)
  4. PR00421 (THIOREDOXIN)
  5. SFLDG00345 (PDI-like)
  6. SIGNAL_PEPTIDE (Sig...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SignalP-noTM
  11. cd02961 (PDI_a_family)
  12. cd02981 (PDI_b_family)
  13. cd02982 (PDI_b'_family)
  14. cd02995 (PDI_a_PDI_...)
  15. mobidb-lite (disord...)

Residue annotation

  1. catalytic residues...
  2. catalytic residues...

Protein sequence

>MIA_04760_1
MKFSTLFLSALASVAFASDVVDLSSSAAEFNNFVDSNPIVLAKFFAPWCGHCKKLAPEYETAAKSLKSKNIALAEVDCTV
NKDLCSSFKIQGYPTLIIFRGSNDQSQYNGGRTSKDIVNYMERELLPAWTELKADNVDSFVNSDEDVSIIGLFESSDKKS
NSSLSTVARQMHHQFSVGLSSDKAVFEKFEIKTLPAVIINLKTADETIVLNDDTDPKFSLDPEYILGKTLAAQILPAGEI
SPETFRGYISAGLPLAYYFYEDEADRDAIRNEILELAKEVKSILNIGFINAKTFGAHAPNLNLNDKQFPAFSIHDMKGNL
KYPILPQDNAPTPDEIIKHVREFVAGTLTPNVKSEPVPKKQEGPVHVVVGKSFKDVVLDSDKDVLVEFYAPWCGHCKNLA
PTYEELASLYANDATASEKVLVAKVDHTANEIAGLEIQGYPTIVLYPAGKKNAPVRYESGSRTLQDLSAFIRDKGTYGVD
GLTLKKAGKVKAKRSKKAKRSKKAKKAKKAKKAGSDEL

GO term prediction

Biological Process

GO:0045454 cell redox homeostasis

Molecular Function

GO:0016853 isomerase activity

Cellular Component

GO:0005783 endoplasmic reticulum