MIA_04726_1

Protein

Length

352 amino acids

Protein function

EGGNOG:	0PFM9	FG10124.1	Quinone oxidoreductase
SGD closest match:	S000000250	ZTA1	Probable quinone oxidoreductase
CGD closest match:	CAL0000175885	orf19.2262	NADPH:quinone reductase

Protein alignments

	%id	Aln length	E-value
A0A0J9XBF8_GEOCN	50.704%	355	2.85e-112	Similar to Saccharomyces cerevisiae YBR046C ZTA1 NADPH-dependent quinone reductase OS=Geotrichum candidum GN=BN980_GECA08s04982g PE=4 SV=1
Q6CEW4_YARLI	45.378%	357	5.07e-97	YALI0B12386p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B12386g PE=4 SV=1
A0A060T9S0_BLAAD	42.090%	354	4.69e-96	ARAD1D14014p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D14014g PE=4 SV=1
UniRef50_B6HQY2	43.343%	353	2.31e-90	Pc22g07320 protein n=27 Tax=Pezizomycotina TaxID=147538 RepID=B6HQY2_PENRW
A0A167DN33_9ASCO	42.222%	360	4.24e-88	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_1371 PE=4 SV=1
A0A1E4TEJ3_9ASCO	29.805%	359	5.15e-27	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_102857 PE=4 SV=1
A0A1E3PMT2_9ASCO	24.011%	354	2.01e-12	NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82990 PE=4 SV=1
Q59Z38_CANAL	24.044%	366	7.22e-11	NADPH:quinone reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2262 PE=4 SV=1
QOR_YEAST	25.208%	361	1.03e-10	Probable quinone oxidoreductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZTA1 PE=1 SV=1
MCA_01628_1	28.313%	166	4.37e-08	MCA_01628_1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0344

Protein family membership

Quinone oxidoreductase PIG3 (IPR014189)

Domains and repeats

Domain
1 - 146
GroES-like (IPR011032)
Alcohol dehydrogenase, N-terminal (IPR013154)
Domain
11 - 349
Polyketide synthase, enoylreductase domain (IPR020843)
Domain
118 - 313
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 352

Detailed signature matches

IPR014189

Quinone oxidoreductase PIG3
1. cd05276 (p53_induci...)
  
  1 - 349
  
  CDD
  cd05276 (p53_inducible_oxidoreductase)
IPR011032

GroES-like
1. SSF50129 (GroES-like)
  
  1 - 146
  
  SUPERFAMILY
  SSF50129 (GroES-like)
IPR020843

Polyketide synthase, enoylreductase domain
1. SM00829 (PKS_ER_nam...)
  
  11 - 349
  
  SMART
  SM00829 (PKS_ER_names_mod)
IPR013154

Alcohol dehydrogenase, N-terminal
1. PF08240 (ADH_N)
  
  29 - 90
  
  Pfam
  PF08240 (ADH_N)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  118 - 313
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

140 - 335

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.18...

1 - 139

GENE3D
G3DSA:3.90.180.10 (G3DSA:3.90.180.10)
PF13602 (ADH_zinc_N_2)

213 - 349

Pfam
PF13602 (ADH_zinc_N_2)
mobidb-lite (disord...)

7 - 27

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

NAD(P) binding sit...

42N

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

43R

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

129E

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

133T

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

136Q

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

154A

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

157S

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

158G

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

159V

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

180V

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

181G

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

185K

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

215Y

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

238P

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

239V

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

260M

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

261G

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

263M

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

288T

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

289T

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

290L

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

338M

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

343T

NAD(P) binding site
42N, 43R, 129E, 133T, 136Q, 154A, 157S, 158G, 159V, 180V, 181G, 185K, 215Y, 238P, 239V, 260M, 261G, 263M, 288T, 289T, 290L, 338M, 343T
CDD
cd05276 (p53_inducible_oxidoreductase)

Protein sequence

>MIA_04726_1
MKAVLIENQKGPSSALHVAETPRPSRASPDDVLVRVRCFGLNRMDILQREGNYPVPPGASPILGVEFSGTVEQVPDNNAP
YAWAVGDKVFGLVTGGAYAQYVVCNQVTLFKFPPAARDLDFVKAAAIPEVWLTATQVVLHIGNLQHNARFLFHAGASGVG
LAALQIARGSAQARTVYCTVGSDSKCDFLLSSFASSWASPSPSCPHPTLLVPINYRTHDFAQAIPAHDPTPLDLIVDPVG
QLYFQRNLDLLGRDATLVLMGLMSGGIVTQSPVDLSPILRKALRVEGTTLRARSIEYKTELRRVFEERVLPHIISGEYKV
FIEKEFAMDDIVEAHNLMESNKTMGKIIVHVN

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features