Protein

MIA_04626_1

Length
1,775 amino acids

Browser: contig06:543019-548501+

Protein function

EGGNOG:0PGM7SET2Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression
SGD closest match:S000003704SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific
CGD closest match:CAL0000174178SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific

Protein alignments

%idAln lengthE-value
MCA_04675_168.820%4490.0MCA_04675_1
A0A0J9X9Q0_GEOCN62.500%4329.35e-178Histone-lysine N-methyltransferase OS=Geotrichum candidum GN=BN980_GECA06s01946g PE=3 SV=1
UniRef50_A0A0J9X9Q062.500%4321.91e-174Histone-lysine N-methyltransferase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9Q0_GEOCN
A0A060T9H8_BLAAD61.416%4388.57e-170Histone-lysine N-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C38060g PE=3 SV=1
A0A167EAW9_9ASCO59.502%4422.32e-168Histone-lysine N-methyltransferase OS=Sugiyamaella lignohabitans GN=SET2 PE=3 SV=1
A0A1E3PD63_9ASCO53.744%4545.14e-148Histone-lysine N-methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_12221 PE=3 SV=1
A0A1E4TFR4_9ASCO53.226%4345.12e-144Histone-lysine N-methyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31467 PE=3 SV=1
SET2_YARLI43.847%5771.06e-133Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=set-2 PE=3 SV=1
SET2_CANAL42.094%4876.91e-112Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SET2 PE=3 SV=1
SET2_YEAST45.843%4454.11e-110Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET2 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9769
Predicted cleavage: 341

Protein family membership

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1775

Detailed signature matches

  1. Family IPR025788
    Histone-lysine N-methyltransferase, SET2, fungi
    1. PS51568 (SAM_MT43_S...)
  2. Domain IPR006560
    AWS domain
    1. SM00570 (shorttest3)
    2. PS51215 (AWS)
  3. Domain IPR001214
    SET domain
    1. PF00856 (SET)
    2. PS50280 (SET)
    3. SM00317 (set_7)
  4. Domain IPR003616
    Post-SET domain
    1. PS50868 (POST_SET)
    2. SM00508 (PostSET_3)
  5. Domain IPR017923
    Transcription factor IIS, N-terminal
    1. SSF47676 (Conserved...)
    2. PF08711 (Med26)
  6. Domain IPR001202
    WW domain
    1. PS01159 (WW_DOMAIN_1)
    2. SM00456 (ww_5)
    3. SSF51045 (WW domain)
    4. PF00397 (WW)
    5. PS50020 (WW_DOMAIN_2)
    6. cd00201 (WW)
  7. Domain IPR013257
    SRI, Set2 Rpb1 interacting
    1. PF08236 (SRI)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.93...
  2. G3DSA:2.170.2...
  3. G3DSA:2.20.70.10
  4. SSF82199 (SET domain)
  5. mobidb-lite (disord...)

Residue annotation

  1. binding pocket cd0...

Protein sequence

>MIA_04626_1
MDHRSRSYSSHNNSKYYSTLTNSQGYSQQYITGASRPPSSGSSTSSLGDHNAMPSNPYTRGPPSSSSSSSSSQHHHNHHN
PSSQQRYPHSHSRSRSHKQLPQQQQPGSSYSRSQSPSYHYTNTSHQRYSSSNTSNTLPRSSSGGNSSSNSSGGPSQSSTT
SSHNAGQKGSQYWFQHNSSPNPNSSTTTSNSNNNSSSNGVGSNSNSLGASGGGSNSLANGNQGIPSSLNKHSSKKHPSIN
SSNRGSHGNGGGGGGGGGGGGGSGRAFPSNKSHRHYHFKNSYHTSSNGNSTGGNNSGSSSSSNSTSKNNNNGNSHHHRYY
GSHSKRGGRRNSFSKEYSRPPSKPQQQQFFPVYDDQVPDDEALNVDYNKELPEILTAFPRQEEETPDSATVQYAFEEEVP
TTESTLDKETFQTPTTDLEDESKPDPENNLKEEPQIELKKVFKEESEQVSKEEPGEKSKVLQIKEKPIEEPSQKTTQTTA
DTPAPELAASPTTETTEKSPSKFTESPERSSPSLTENPVEVSEEPHQIIEDVPMEDAPETANQELETHLKIKEETRETDA
PFTQPTATSQSPSFGSPKHFDVSTGNSEHEELLNIKHEKLYTTPKIEEDQNKPEEEEHEEKFSVLKHYPKNESTDTSIKE
NLSDSSLSPPSDSEDDEIMRHIAVAESIRNGIEESSSESPSISSSPISPPSEPPRSSNLKELSKSLSPPAPPQSPALPPP
SKASENDDDDENDYDQNDDLPLPAQASSPYAREEATTPEPPSLMDDDDGIIMSPVTKMPKKRRSKKTKKEQQIHYQLFND
LPSKTEEAEQTFEVLLESIYTKKNLGNSGQFDAMTCDCRQEWDGNRNLACGDDSDCINRLTSIECVNSKCFCGKDCRNQR
FQKHEYAKIDVIQTKLKGYGVRALENLSQGTFVYEYVGEVISEAGFRKRAEDYKKGGNRHFYFMMLQKGEFIDATSKGGL
ARFCNHSCNPNCYVDKWVVGDKLRMGIFTKRDILKGEEITFDYNVDRYGADAQPCYCGEPTCVGILGGKTQTEAVNKLPQ
PVLDALDMDDSDEDTWMTSKKNHTKKKPRKTEDELDEDFDIDEDDKYETSALPTKPVTVYSVSKIMSSLMQAREDWLVNK
LLSRIANTSDTAIHFRVMQMHGYQIFSNLLRDWNLDGNKEKYPRTRIILEIMTKWPRKTKNKISSSKIEETVQDISLHCE
DEEIKDLAHQLLKAWASLQMAYRIPRREKKQDEEPEPVSVSSESETKKDTDAKKEPETFQANSHSSHHNSNHNHHHHHHN
TNSQQPQPQQSQQQTNKFLSKKGNQDRYADLNLPEGPRKTYLAQQAVLSDILPPGWRSAEAPGGRVYYYNRKLNITQWER
PMPVLTKGGNVINLLNGGFYRNPPAGLGVNASVSAGTVANGTGAVAVTPVTALTTASATIAGSNSSAYGQYSAVGQYGED
YSAVSDSGALIRHESEVGLGNINSLSRNGSRSGSMTALAGASGPTAAAAAALGTGAVQDMRALKKATEELTLQKIIEEAC
QKKKEGTTTALSSSSALSRSNSHGTDPISRSGSALGISRRSSSLDLFDEDDSVSPGSETLLEMQSRVLQKNFARIVPNIV
VRYESQIGHDNVKQYSKEIVRILVQKELRAKPSSVDIDFGSEKKLKIKTFVKTYMGKVLEKIKKRRQNDLRAEIARSGAG
ASAGMGGLATAVLTTGAASTSASSTTSTPTESATIQNGTPVVGSAPNSTEDPRLVRFHGEDVGMTPGRSSGSDNDNIDGY
MDGWGTTYGGIVMGE

GO term prediction

Biological Process

GO:0006354 DNA-templated transcription, elongation
GO:0006355 regulation of transcription, DNA-templated
GO:0010452 histone H3-K36 methylation
GO:0034968 histone lysine methylation

Molecular Function

GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046975 histone methyltransferase activity (H3-K36 specific)

Cellular Component

GO:0005634 nucleus
GO:0005694 chromosome