Protein
MIA_04596_1
Length
623 amino acids
Browser: contig06:460840-462775+
Protein function
| EGGNOG: | 0PFJ9 | PAC1 | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein- mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs (By similarity) |
|---|---|---|---|
| SGD closest match: | S000005795 | PAC1 | Nuclear distribution protein PAC1 |
| CGD closest match: | CAL0000197627 | PAC1 | Nuclear distribution protein PAC1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_02879_1 | 55.244% | 677 | 0.0 | MCA_02879_1 |
| A0A0J9XCY2_GEOCN | 64.557% | 474 | 0.0 | Nuclear distribution protein PAC1 OS=Geotrichum candidum GN=PAC1 PE=3 SV=1 |
| A0A060TI28_BLAAD | 58.209% | 469 | 0.0 | Nuclear distribution protein PAC1 OS=Blastobotrys adeninivorans GN=PAC1 PE=3 SV=1 |
| A0A1E3PL35_9ASCO | 51.829% | 492 | 5.64e-171 | Nuclear distribution protein PAC1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=PAC1 PE=3 SV=1 |
| UniRef50_D5GBI7 | 48.340% | 482 | 1.43e-150 | Nuclear distribution protein PAC1 n=38 Tax=saccharomyceta TaxID=716545 RepID=LIS1_TUBMM |
| A0A167E1S5_9ASCO | 63.729% | 295 | 5.47e-142 | Pac1p OS=Sugiyamaella lignohabitans GN=PAC1 PE=4 SV=1 |
| LIS1_YARLI | 43.710% | 469 | 9.86e-126 | Nuclear distribution protein PAC1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAC1 PE=3 SV=1 |
| A0A1E4TEQ2_9ASCO | 40.086% | 464 | 3.73e-111 | Nuclear distribution protein PAC1 OS=Tortispora caseinolytica NRRL Y-17796 GN=PAC1 PE=3 SV=1 |
| LIS1_CANAL | 30.417% | 480 | 2.32e-65 | Nuclear distribution protein PAC1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAC1 PE=3 SV=1 |
| LIS1_YEAST | 27.743% | 483 | 3.88e-47 | Nuclear distribution protein PAC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAC1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0877
Protein family membership
- Dynein regulator LIS1 (IPR017252)
Domains and repeats
-
Domain
-
Repeat
-
Repeat
1
100
200
300
400
500
623
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
-
SSF109925 (Lissence...)
-
cd00200 (WD40)
-
mobidb-lite (disord...)
Residue annotation
-
structural tetrad ...
Protein sequence
>MIA_04596_1 MQNPSLLTDRQRSELNRTILAYLRYNNVPNEVVKGINHVLNGDSPDNAFPRQIGYLENADEENQDFEDKDENEVARRHEQ EQLETKKLAQVLEKKWTSVVRLQRKVLDLESQVSNLSQELENMPVLAAGRRGAGGRGANGLGSAVDPVSWLPRAPAKFSL SGHRQPITAVAFHAVYSVLASASEDGTIKIWDWELGELERTIKGHTKAVLDVDFGGREANSDGNGSSSTSGYLLASCSSD LTIKLWDPENDYANIRTLTGHEHTISSVRFTPSGAHLVSASRDQTVRIWEVKTGFAVRTIKAHTAWVKCVVPTWDSQYVI SGSIDQTARISSIVTGETKLTLTGHEHVVECAAFAPVTAHANLAALEGVRAPVASTLSPSFEYAATGSRDKTIRLWNTRG ELIATLRGHDNWVRGLAFHPGGRYLLSVSDDRSIRCWDLTQKGRCAKVLADAHHHFISCIRWAPPISSANDSAETASSGS LQYSPTRTRVSPSKLSLGKPRIANSSTGLAMGGISRALSRHNTPAQRSTSGSGASGILGSGVGGSRRVFSNGTGGLRDIY GTPSVPAGPNTSTSTSTTTESSTTGDDTTAPETSGTNLPAAVLRGMRCVIATGSVDLDIKIWM
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.